Search Results - "Grech, O."

Intracranial pressure directly predicts headache morbidity in idiopathic intracranial hypertension by Mollan, S. P., Wakerley, B. R., Alimajstorovic, Z., Mitchell, J., Ottridge, R., Yiangou, A., Thaller, M., Gupta, A., Grech, O., Lavery, G., Brock, K., Sinclair, A. J.

“…Objective Headache is the predominant disabler in idiopathic intracranial hypertension (IIH). The aim was to characterise headache and investigate the…”
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Idiopathic intracranial hypertension: evaluation of admissions and emergency readmissions following primary shunt surgery through the United Kingdom hospital episode statistic dataset between 2002-2020 by Mollan, S., Mytton, J., Tsermoulas, G., Sinclair, A., Grech, O.

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Erenumab for headaches in idiopathic intracranial hypertension: a prospective open-label evaluation by Yiangou, A., Mitchell, J.L., Fisher, C., Edwards, J., Vijay, V., Alimajstorovic, Z., Grech, O., Lavery, G.G., Mollan, S.P., Sinclair, A.J.

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Intracranial pressure determines headache morbidity in idiopathic intracranial hypertension by Mollan, S., Wakerley, B., Alimajstorovic, Z., Mitchell, J.L., Ottridge, R., Yiagnou, A., Thaller, M., Grech, O., Lavery, G., Brock, K., Sinclair, A.

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Bariatric surgery versus community weight management intervention for the treatment of idiopathic intracranial hypertension (IIH:WT): a randomized controlled trial by Mollan, S., Mitchell, J.L., Ottridge, R., Aguiar, M., Yiangou, A., Alimajstorovic, Z., Cartwright, D., Grech, O., Lavery, G., Westgate, C., Vijay, V., Scotton, W., Wakerley, B., Matthews, T., Ansons, A., Hickman, S., Benzimra, J., Rick, C., Singhal, R., Tahrani, A., Brock, K., Frew, E., Sinclair, A.

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Influence of debrisoquine phenotype and of quinidine on mexiletine disposition in man by Turgeon, J, Fiset, C, Giguère, R, Gilbert, M, Moerike, K, Rouleau, J R, Kroemer, H K, Eichelbaum, M, Grech-Bélanger, O, Bélanger, P M

“…Mexiletine is a low clearance drug which undergoes extensive metabolism in man. In vitro studies with human liver microsomes have suggested that major…”
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A Neuro-Ophthalmologist’s Guide to Advances in Intracranial Pressure Measurements by Mollan, Susan P, Momin, Sehrish N.A, Khatkar, Pavan S, Grech, Olivia, Sinclair, Alex J, Tsermoulas, Georgios

“…Cerebrospinal fluid disorders have a wide-ranging impact on vision, headache, cognition and a person's quality of life. Due to advances in technology and…”
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Isolation and structural characterization by spectroscopic methods of two glucuronide metabolites of mexiletine after N-oxidation and deamination by Turgeon, J, Paré, J R, Lalande, M, Grech-Bélanger, O, Bélanger, P M

“…Urine samples from control and mexiletine-treated human subjects or rabbits (test group) were collected and passed through an ion exchange resin to isolate…”
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Stereoselective disposition of mexiletine in man by Grech‐Belanger, O, Turgeon, J, Gilbert, M

“…The pharmacokinetics of S‐(+)‐ and R‐(‐)‐mexiletine and of the corresponding conjugates were investigated in six healthy young volunteers after administration…”
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Deacetylation of diltiazem by rat liver by LeBoeuf, E, Grech-Bélanger, O

“…The enzyme system mediating the hydrolysis of the calcium antagonist diltiazem to give deacetyldiltiazem was characterized in the rat. Tissue distribution…”
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Meta-hydroxymexiletine, a new metabolite of mexiletine. Isolation, characterization, and species differences in its formation by Grech-Bélanger, O, Turgeon, J, Lalande, M, Bélanger, P M

“…Meta-hydroxymexiletine [1-(3-hydroxy,2,6-dimethyl)phenoxy-2-amino-propane], a novel metabolite of the antiarrhythmic drug mexiletine, was isolated from urine…”
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Erythrocyte and serum distribution of mexiletine in man by Turgeon, J, Grech-Bélanger, O, Gilbert, M

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High pressure liquid chromatographic assay for mexiletine in serum by Grech-Bélanger, O, Turgeon, J, Gilbert, M

“…A highly sensitive, rapid, and specific high pressure liquid chromatographic assay for the analysis of the antiarrhythmic agent mexiletine is reported. The…”
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Metabolic reduction of 1-nitrosoadamantane by rabbit liver microsomes. Properties of a C-nitroso reductase system by Bélanger, P M, Grech-Bélanger, O

“…Washed microsomes from rabbit liver reduced 1-nitrosoadamantane to N-hydroxy-1-aminoadamantane in the presence of a cofactor solution under aerobic conditions;…”
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Depressive effect of amiodarone on hepatic drug metabolism in the rat by Grech-Bélanger, O

“…The effect of pretreatment of rats with three daily i.p. doses of 25, 50 and 100 mg/kg of the antiarrhythmic agent, amiodarone, on the activity of some hepatic…”
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Occupational hazards in management of an experimental constructed wetlands by Serafino, L, Bellia, S, Ciantia, F, Grech, O, Luca, N, Milana, E, Bellia, M

“…The sewage from urban settlements is an important cause of water pollution. Recent Italian legislation offers new possibilities for intervention in the…”
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Resolution and electrophysiological effects of mexiletine enantiomers by Turgeon, J, Uprichard, A C, Bélanger, P M, Harron, D W, Grech-Bélanger, O

“…Resolution of mexiletine enantiomers from the racemic mixture has been achieved by fractional crystallization through the formation of diastereoisomeric…”
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2,6-Dimethylphenol: a new metabolite of mexiletine by Grech-Bélanger, O, Turgeon, J, Lalande, M

“…A new metabolite, 2,6-dimethylphenol obtained by O-dealkylation of mexiletine by rabbit liver was identified. A g.c.-f.i.d. method was developed for its…”
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The effect of fleroxacin on hepatic drug metabolism in the rat by Grech-Bélanger, O, Francoeur, J, Le Bel, M

“…Pretreatment of rats with repeated i.p. doses of fleroxacin had no effect on the hepatic O- and N-demethylation of p-nitroanisole (PN) and aminopyrine (A)…”
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High-performance liquid chromatographic assay for mexiletine enantiomers in human plasma by Grech-Bélanger, O, Turgeon, J, Gilbert, M

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