Crosslinking of Chitosan with Dialdehyde Chitosan as a New Approach for Biomedical Applications

Materials based on natural high molecular compounds are particularly interesting for biomedical applications. It is known that the cross-linking agent used for preparation of biomacromolecule-based materials is as important as used biopolymer. Therefore, natural cross-linkers containing reactive car...

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Published in:	Materials Vol. 13; no. 15; p. 3413
Main Authors:	Wegrzynowska-Drzymalska, Katarzyna, Grebicka, Patrycja, Mlynarczyk, Dariusz T, Chelminiak-Dudkiewicz, Dorota, Kaczmarek, Halina, Goslinski, Tomasz, Ziegler-Borowska, Marta
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 03-08-2020 MDPI
Subjects:	Biocompatibility Biomedical materials Biopolymers Carbonyl groups Carbonyls Chitosan Contact angle Cooling Coronaviruses COVID-19 cross-linking Crosslinking dialdehyde chitosan dialdehyde starch Fourier transforms Glutaraldehyde Glycerol Low molecular weights Mechanical properties Microtox® test Molecular weight Morphology Polyethylene glycol Polysaccharides Scanning electron microscopy Severe acute respiratory syndrome coronavirus 2 Spectrum analysis Surface properties Thermodynamic properties Tissue engineering Toxicity United States > US chitosan dialdehyde chitosan dialdehyde starch cross-linking Microtox® test
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Summary:	Materials based on natural high molecular compounds are particularly interesting for biomedical applications. It is known that the cross-linking agent used for preparation of biomacromolecule-based materials is as important as used biopolymer. Therefore, natural cross-linkers containing reactive carbonyl groups are of great interest especially for modifying properties of natural polysaccharides. One of the most popular cross-linking agents is glutaraldehyde. Nevertheless, the unreacted particles can be released from the cross-linked material and cause cytotoxic effects. This can be eliminated when using a cross-linker based e.g., on polysaccharides. This article describes quick and efficient synthesis of dialdehyde chitosan (DACS) and its application for the preparation of chitosan films. Materials obtained with different amount of DACS were fully characterized in terms of structure and surface morphology. Thermal and mechanical properties as well as hydrophilic character were also examined. The results obtained were compared with the materials obtained by cross-linking chitosan with low molecular weight glutaraldehyde and high molecular weight cross-linking agent based on polysaccharide-dialdehyde starch. Toxicity of all obtained materials was tested using the Microtox test. It has been shown that due to better mechanical, thermal and surface properties as well as lower toxicity, dialdehyde chitosan is a very promising crosslinking agent.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1996-1944 1996-1944
DOI:	10.3390/ma13153413