Search Results - "Greber, Urs F."

Virus and Host Mechanics Support Membrane Penetration and Cell Entry by Greber, Urs F

“…Viruses are quasi-inert macromolecular assemblies. Their metastable conformation changes during entry into cells, when chemical and mechanical host cues expose…”
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Neuropilin-1 is a host factor for SARS-CoV-2 infection by Daly, James L, Simonetti, Boris, Klein, Katja, Chen, Kai-En, Williamson, Maia Kavanagh, Antón-Plágaro, Carlos, Shoemark, Deborah K, Simón-Gracia, Lorena, Bauer, Michael, Hollandi, Reka, Greber, Urs F, Horvath, Peter, Sessions, Richard B, Helenius, Ari, Hiscox, Julian A, Teesalu, Tambet, Matthews, David A, Davidson, Andrew D, Collins, Brett M, Cullen, Peter J, Yamauchi, Yohei

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), uses the viral spike (S) protein for…”
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Virus Infection Variability by Single-Cell Profiling by Suomalainen, Maarit, Greber, Urs F

“…Cell-to-cell variability of infection has long been known, yet it has remained one of the least understood phenomena in infection research. It impacts on…”
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A versatile automated pipeline for quantifying virus infectivity by label-free light microscopy and artificial intelligence by Petkidis, Anthony, Andriasyan, Vardan, Murer, Luca, Volle, Romain, Greber, Urs F.

“…Virus infectivity is traditionally determined by endpoint titration in cell cultures, and requires complex processing steps and human annotation. Here we…”
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The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and -3 infection by Bieri, Manuela, Hendrickx, Rodinde, Bauer, Michael, Yu, Bin, Jetzer, Tania, Dreier, Birgit, Mittl, Peer R E, Sobek, Jens, Plückthun, Andreas, Greber, Urs F, Hemmi, Silvio

“…Mammalian adenoviruses (AdVs) comprise more than ~350 types including over 100 human (HAdVs) and just three mouse AdVs (MAdVs). While most HAdVs initiate…”
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Drifting motions of the adenovirus receptor CAR and immobile integrins initiate virus uncoating and membrane lytic protein exposure by Burckhardt, Christoph J, Suomalainen, Maarit, Schoenenberger, Philipp, Boucke, Karin, Hemmi, Silvio, Greber, Urs F

“…Viral particle binding to plasma membrane receptors elicits virus motions, recruits signaling proteins, and triggers membrane bending and fission, finally…”
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Niclosamide is a proton carrier and targets acidic endosomes with broad antiviral effects by Jurgeit, Andreas, McDowell, Robert, Moese, Stefan, Meldrum, Eric, Schwendener, Reto, Greber, Urs F

“…Viruses use a limited set of host pathways for infection. These pathways represent bona fide antiviral targets with low likelihood of viral resistance. We…”
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Tracking Viral Genomes in Host Cells at Single-Molecule Resolution by Wang, I-Hsuan, Suomalainen, Maarit, Andriasyan, Vardan, Kilcher, Samuel, Mercer, Jason, Neef, Anne, Luedtke, Nathan W., Greber, Urs F.

“…Viral DNA trafficking in cells has large impacts on physiology and disease development. Current methods lack the resolution and accuracy to visualize and…”
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MxB is an interferon-induced restriction factor of human herpesviruses by Crameri, Michel, Bauer, Michael, Caduff, Nicole, Walker, Raphael, Steiner, Fiona, Franzoso, Francesca D., Gujer, Cornelia, Boucke, Karin, Kucera, Talissa, Zbinden, Andrea, Münz, Christian, Fraefel, Cornel, Greber, Urs F., Pavlovic, Jovan

“…The type I interferon (IFN) system plays an important role in controlling herpesvirus infections, but it is unclear which IFN-mediated effectors interfere with…”
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How Cells Tune Viral Mechanics—Insights from Biophysical Measurements of Influenza Virus by Greber, Urs F.

“…During replication, the physical state of a virus is controlled by assembly and disassembly processes, when particles are put together and dismantled by…”
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Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor by Stichling, Nicole, Suomalainen, Maarit, Flatt, Justin W, Schmid, Markus, Pacesa, Martin, Hemmi, Silvio, Jungraithmayr, Wolfgang, Maler, Mareike D, Freudenberg, Marina A, Plückthun, Andreas, May, Tobias, Köster, Mario, Fejer, György, Greber, Urs F

“…Macrophages are a diverse group of phagocytic cells acting in host protection against stress, injury, and pathogens. Here, we show that the scavenger receptor…”
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Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control by Schmid, Markus, Ernst, Patrick, Honegger, Annemarie, Suomalainen, Maarit, Zimmermann, Martina, Braun, Lukas, Stauffer, Sarah, Thom, Cristian, Dreier, Birgit, Eibauer, Matthias, Kipar, Anja, Vogel, Viola, Greber, Urs F., Medalia, Ohad, Plückthun, Andreas

“…Most systemic viral gene therapies have been limited by sequestration and degradation of virions, innate and adaptive immunity, and silencing of therapeutic…”
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Viral mechanisms for docking and delivering at nuclear pore complexes by Flatt, Justin W., Greber, Urs F.

“…Some viruses possess the remarkable ability to transport their genomes across nuclear pore complexes (NPCs) for replication inside the host cell’s intact…”
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Imaging, Tracking and Computational Analyses of Virus Entry and Egress with the Cytoskeleton by Wang, I-Hsuan, Burckhardt, Christoph J, Yakimovich, Artur, Greber, Urs F

“…Viruses have a dual nature: particles are "passive substances" lacking chemical energy transformation, whereas infected cells are "active substances"…”
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The HSV-1 Transcription Factor ICP4 Confers Liquid-Like Properties to Viral Replication Compartments by Seyffert, Michael, Georgi, Fanny, Tobler, Kurt, Bourqui, Laurent, Anfossi, Michela, Michaelsen, Kevin, Vogt, Bernd, Greber, Urs F, Fraefel, Cornel

“…Herpes Simplex Virus Type-1 (HSV-1) forms progeny in the nucleus within distinct membrane-less inclusions, the viral replication compartments (VRCs), where…”
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Co-option of Membrane Wounding Enables Virus Penetration into Cells by Luisoni, Stefania, Suomalainen, Maarit, Boucke, Karin, Tanner, Lukas B., Wenk, Markus R., Guan, Xue Li, Grzybek, Michał, Coskun, Ünal, Greber, Urs F.

“…During cell entry, non-enveloped viruses undergo partial uncoating to expose membrane lytic proteins for gaining access to the cytoplasm. We report that…”
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The adenovirus major core protein VII is dispensable for virion assembly but is essential for lytic infection by Ostapchuk, Philomena, Suomalainen, Maarit, Zheng, Yueting, Boucke, Karin, Greber, Urs F, Hearing, Patrick

“…The Adenovirus (Ad) genome within the capsid is tightly associated with a virus-encoded, histone-like core protein-protein VII. Two other Ad core proteins, V…”
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A Single Point Mutation in the Rhinovirus 2B Protein Reduces the Requirement for Phosphatidylinositol 4-Kinase Class III Beta in Viral Replication by Roulin, Pascal S, Murer, Luca P, Greber, Urs F

“…Rhinoviruses (RVs) replicate on cytoplasmic membranes derived from the Golgi apparatus. They encode membrane-targeted proteins 2B, 2C, and 3A, which control…”
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The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections by Prasad, Vibhu, Suomalainen, Maarit, Jasiqi, Yllza, Hemmi, Silvio, Hearing, Patrick, Hosie, Louise, Burgert, Hans-Gerhard, Greber, Urs F.

“…Persistent viruses cause chronic disease, and threaten the lives of immunosuppressed individuals. Here, we elucidate a mechanism supporting the persistence of…”
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Fluorescence Tracking of Genome Release during Mechanical Unpacking of Single Viruses by Ortega-Esteban, Alvaro, Bodensiek, Kai, San Martín, Carmen, Suomalainen, Maarit, Greber, Urs F, de Pablo, Pedro J, Schaap, Iwan A. T

“…Viruses package their genome in a robust protein coat to protect it during transmission between cells and organisms. In a reaction termed uncoating, the virus…”
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