Search Results - "Greaves, MF"

Origins of chromosome translocations in childhood leukaemia by Greaves, Mel F, Wiemels, Joe

“…Chromosome translocations are often early or initiating events in leukaemogenesis, occurring prenatally in most cases of childhood leukaemia. Although these…”
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Leukemia in twins: lessons in natural history by Greaves, Mel F., Maia, Ana Teresa, Wiemels, Joseph L., Ford, Anthony M.

“…Identical infant twins with concordant leukemia were first described in 1882, and since that time many such pairs of infants and older children have been…”
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Expression of the CD34 Gene in Vascular Endothelial Cells by Fina, Laura, Molgaard, Harald V., Robertson, David, Bradley, Nicholas J., Monaghan, Paul, Delia, Domenico, Sutherland, D.Robert, Baker, Michael A., Greaves, Melvyn F.

“…All seven of a set of CD34 monoclonal antibodies that recognize epitopes on an ≍110 Kd glycoprotein on human hemopoietic progenitor cells also bind to vascular…”
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Aetiology of acute leukaemia by Greaves, M F

“…Ionising radiation, in high dose and with acute exposure, is a factor that has been implicated in leukaemogenesis, but what is the evidence for leukaemogenesis…”
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Molecular characterization of genomic AML1-ETO fusions in childhood leukemia by XIAO, Z, GREAVES, M. F, BUFFLER, P, SMITH, M. T, SEGAL, M. R, DICKS, B. M, WIENCKE, J. K, WIEMELS, J. L

“…T(8;21) AML1(CBFA2)-ETO(MTG8) is the most common chromosomal translocation in acute myeloid leukemia (AML) in both children and adults. We sought to understand…”
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Day care in infancy and risk of childhood acute lymphoblastic leukaemia: findings from UK case-control study by Gilham, C, Peto, J, Simpson, J, Roman, E, Eden, T O B, Greaves, M F, Alexander, F E

“…Abstract Objective To test the hypothesis that reduced exposure to common infections in the first year of life increases the risk of developing acute…”
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Prenatal origin of acute lymphoblastic leukaemia in children by Wiemels, JL, Cazzaniga, G, Daniotti, M, Eden, OB, Addison, GM, Masera, G, Saha, V, Biondi, A, Greaves, MF

“…There is little current insight into the natural history of childhood leukaemia or the timing of relevant mutational events. TEL-AML1 gene fusion due to…”
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Methylenetetrahydrofolate Reductase (MTHFR) Polymorphisms and Risk of Molecularly Defined Subtypes of Childhood Acute Leukemia by Wiemels, Joseph L., Smith, Rosalyn N., Taylor, G. Malcolm, Eden, Osborn B., Alexander, Freda E., Greaves, Mel F., United Kingdom Childhood Cancer Study Investigators

“…Low folate intake as well as alterations in folate metabolism as a result of polymorphisms in the enzyme methylenetetrahydrofolate reductase (MTHFR) have been…”
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Molecular genetics, natural history and the demise of childhood leukaemia by Greaves, M.

“…After graduating at University College (BSc) and Middlesex Hospital Medical School (Ph.D), Mel worked at the Karolinska Institute, Stockholm, and the National…”
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Backtracking Leukemia to Birth: Identification of Clonotypic Gene Fusion Sequences in Neonatal Blood Spots by Gale, Karin B., Ford, Anthony M., Repp, Reinald, Borkhardt, Arndt, Keller, Claudia, Eden, Osborn B., Greaves, Mel F.

“…Epidemiological evidence has suggested that some pediatric leukemias may be initiated in utero and, for some pairs of identical twins with concordant leukemia,…”
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Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion by ALEXANDER, Freda E, PATHEAL, Sherry L, HUSSEIN, Hany, ISHII, Eiichi, KAMEL, Azza M, LABRA, Silvia, MAGALHAES, Isis Q, MIZUTANI, Shuki, PETRIDOU, Eleni, POMBO DE OLIVEIRA, Maria, YUEN, Patrick, WIEMELS, Joseph L, BIONDI, Andrea, GREAVES, Mel F, BRANDALISE, Silvia, CABRERA, Maria-Elena, CHAN, Li C, ZHU CHEN, CIMINO, Giuseppe, CORDOBA, Jose-Carlos, GU, Long-Jun

“…Infant acute leukemia (IAL) frequently involves breakage and recombination of the MLL gene with one of several potential partner genes. These gene fusions…”
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A lack of a functional NAD(P)H:Quinone oxidoreductase allele is selectively associated with pediatric leukemias that have MLL fusions by WIEMELS, J. L, PAGNAMENTA, A, TAYLOR, G. M, EDEN, O. B, ALEXANDER, F. E, GREAVES, M. F

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Infant leukaemia biology, aetiology and treatment by Greaves, M F

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Origins of “late” relapse in childhood acute lymphoblastic leukemia with TEL-AML1 fusion genes by Ford, Anthony M., Fasching, Karin, Panzer-Grümayer, E. Renate, Koenig, Margit, Haas, Oskar A., Greaves, Mel F.

“…Approximately 20% of childhood B-precursor acute lymphoblastic leukemia (ALL) has a TEL-AML1 fusion gene, often in association with deletions of the…”
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Prenatal origin of hyperdiploid acute lymphoblastic leukemia in identical twins by MAIA, A. T, VAN DER VELDEN, V. H. J, HARRISON, C. J, SZCZEPANSKI, T, WILLIAMS, M. D, GRIFFITHS, M. J, VAN DONGEN, J. J. M, GREAVES, M. F

“…Studies in identical twins and with neonatal blood spots (Guthrie cards) have backtracked the origin of childhood acute leukemia and their associated…”
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The putative role of transforming viruses in childhood acute lymphoblastic leukemia by MacKenzie, J, Greaves, MF, Eden, TO, Clayton, RA, Perry, J, Wilson, KS, Jarrett, RF

“…LRF Virus Centre, Institute of Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow, G61 1QH, UK. Epidemiological evidence suggests that…”
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Detecting Small-Area Similarities in the Epidemiology of Childhood Acute Lymphoblastic Leukemia and Diabetes Mellitus, Type 1: A Bayesian Approach by Feltbower, Richard G., Manda, Samuel O. M., Gilthorpe, Mark S., Greaves, Mel F., Parslow, Roger C., Kinsey, Sally E., Bodansky, H. Jonathan, McKinney, Patricia A.

“…Childhood acute lymphoblastic leukemia and diabetes mellitus, type 1, have common epidemiologic and etiologic features, including correlated international…”
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Molecular tracking of leukemogenesis in a triplet pregnancy by Maia, Ana Teresa, Ford, Anthony M., Jalali, G. Reza, Harrison, Christine J., Taylor, G. Malcolm, Eden, Osborn B., Greaves, Mel F.

“…The occurrence of childhood acute lymphoblastic leukemia (ALL) in 2 of 3 triplets provided a unique opportunity for the investigation of leukemogenesis and the…”
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Commentary: Birth order and risk of childhood acute lymphoblastic leukaemia (ALL) by Greaves, M F

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An infectious etiology for common acute lymphoblastic leukemia in childhood? by Greaves, M F, Alexander, F E

“…Childhood leukemia is a biologically and clinically diverse disease and is likely to arise via a number of etiological pathways. The common, B-cell precursor,…”
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