Search Results - "Greaves, M. F."

Aetiology of acute leukaemia by Greaves, M F

“…Ionising radiation, in high dose and with acute exposure, is a factor that has been implicated in leukaemogenesis, but what is the evidence for leukaemogenesis…”
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Day care in infancy and risk of childhood acute lymphoblastic leukaemia: findings from UK case-control study by Gilham, C, Peto, J, Simpson, J, Roman, E, Eden, T O B, Greaves, M F, Alexander, F E

“…Abstract Objective To test the hypothesis that reduced exposure to common infections in the first year of life increases the risk of developing acute…”
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Prenatal origin of acute lymphoblastic leukaemia in children by Wiemels, JL, Cazzaniga, G, Daniotti, M, Eden, OB, Addison, GM, Masera, G, Saha, V, Biondi, A, Greaves, MF

“…There is little current insight into the natural history of childhood leukaemia or the timing of relevant mutational events. TEL-AML1 gene fusion due to…”
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Cord blood donor cell leukemia in recipients by Greaves, M F

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Prenatal origin of hyperdiploid acute lymphoblastic leukemia in identical twins by MAIA, A. T, VAN DER VELDEN, V. H. J, HARRISON, C. J, SZCZEPANSKI, T, WILLIAMS, M. D, GRIFFITHS, M. J, VAN DONGEN, J. J. M, GREAVES, M. F

“…Studies in identical twins and with neonatal blood spots (Guthrie cards) have backtracked the origin of childhood acute leukemia and their associated…”
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Ultrastructural localization of bcl-2 protein by Monaghan, P, Robertson, D, Amos, TA, Dyer, MJ, Mason, DY, Greaves, MF

“…Previous cell subfractionation studies have indicated that bcl-2 is an inner mitochondrial membrane protein. We have sought to determine the ultrastructural…”
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Infant leukaemia biology, aetiology and treatment by Greaves, M F

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Expression of the CD34 Gene in Vascular Endothelial Cells by Fina, Laura, Molgaard, Harald V., Robertson, David, Bradley, Nicholas J., Monaghan, Paul, Delia, Domenico, Sutherland, D.Robert, Baker, Michael A., Greaves, Melvyn F.

“…All seven of a set of CD34 monoclonal antibodies that recognize epitopes on an ≍110 Kd glycoprotein on human hemopoietic progenitor cells also bind to vascular…”
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Speculations on the cause of childhood acute lymphoblastic leukemia by Greaves, M F

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Molecular characterization of genomic AML1-ETO fusions in childhood leukemia by XIAO, Z, GREAVES, M. F, BUFFLER, P, SMITH, M. T, SEGAL, M. R, DICKS, B. M, WIENCKE, J. K, WIEMELS, J. L

“…T(8;21) AML1(CBFA2)-ETO(MTG8) is the most common chromosomal translocation in acute myeloid leukemia (AML) in both children and adults. We sought to understand…”
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Origins of chromosome translocations in childhood leukaemia by Greaves, Mel F, Wiemels, Joe

“…Chromosome translocations are often early or initiating events in leukaemogenesis, occurring prenatally in most cases of childhood leukaemia. Although these…”
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International parallels in leukaemia and diabetes epidemiology by Feltbower, R G, McKinney, P A, Greaves, M F, Parslow, R C, Bodansky, H J

“…Acute lymphoblastic leukaemia (ALL) and type 1 diabetes have an environmental aetiology and common epidemiological features. Incidence rates and national…”
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Screening for herpesvirus genomes in common acute lymphoblastic leukemia by MACKENZIE, J, GALLAGHER, A, CLAYTON, R. A, PERRY, J, EDEN, O. B, FORD, A. M, GREAVES, M. F, JARRETT, R. F

“…There is epidemiological evidence that infection may play a role in the etiology of childhood leukemia in particular common B cell precursor acute…”
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Stem cell origins of leukaemia and curability by GREAVES, M. F

“…It is suggested that most childhood acute lymphoblastic leukaemias and some other paediatric cancers are chemo-curable because they arise in stem cell…”
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Commentary: Birth order and risk of childhood acute lymphoblastic leukaemia (ALL) by Greaves, M F

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An infectious etiology for common acute lymphoblastic leukemia in childhood? by Greaves, M F, Alexander, F E

“…Childhood leukemia is a biologically and clinically diverse disease and is likely to arise via a number of etiological pathways. The common, B-cell precursor,…”
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Clustering of childhood leukaemia in Hong Kong: association with the childhood peak and common acute lymphoblastic leukaemia and with population mixing by ALEXANDER, F. E, CHAN, L. C, LAM, T. H, YUEN, P, LEUNG, N. K, HA, S. Y, YUEN, H. L, LI, C. K, LAU, Y. L, GREAVES, M. F

“…Incidence data of childhood leukaemia (CL) in Hong Kong (1984-90) have been analysed for evidence of variation between small areas. All cases (n=261) were…”
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CD34 Expression Is Regulated Reciprocally With Adhesion Molecules in Vascular Endothelial Cells In Vitro by Delia, D., Lampugnani, M.G., Resnati, M., Dejana, E., Aiello, A., Fontanella, E., Soligo, D., Pierotti, M.A., Greaves, M.F.

“…Freshly cultured vascular endothelial cells express the CD34 antigen in a diffuse cell surface pattern with some concentration on microvilli. Expression is…”
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Activation of the β-Globin Locus Control Region Precedes Commitment to the Erythroid Lineage by Jimenez, Gerardo, Griffiths, Stephen D., Ford, Anthony M., Greaves, Melvyn F., Enver, Tariq

“…The β-globin locus control region (LCR) is characterized by erythroid-specific DNase I hypersensitive sites and is involved in the chromatin organization,…”
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Regulation of the myeloperoxidase enhancer binding proteins Pu1, C-EBP alpha, -beta, and -delta during granulocyte-lineage specification by Ford, A M, Bennett, C A, Healy, L E, Towatari, M, Greaves, M F, Enver, T

“…We have compared the molecular architecture and function of the myeloperoxidase upstream enhancer in multipotential versus granulocyte-committed hematopoietic…”
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