Search Results - "Grdic, D"

Paradoxical IgA immunity in CD4-deficient mice. Lack of cholera toxin- specific protective immunity despite normal gut mucosal IgA differentiation by Hornquist, CE, Ekman, L, Grdic, KD, Schon, K, Lycke, NY

“…Using normal and CD4 gene-targeted (CD4-/-) mice, we asked whether mucosal immune responses and IgA B cell differentiation require the presence of CD4+ T…”
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Interferon‐γ receptor‐deficient mice exhibit impaired gut mucosal immune responses but intact oral tolerance by KJERRULF, M., GRDIC, D., EKMAN, L., SCHÖN, K., VAJDY, M., LYCKE, N. Y.

“…Interferon‐γ (IFN‐γ) receptor knock‐out (IFN‐γR−/−) mice were used to analyse the role of IFN‐γ in mucosal immune responses following oral immunization. We…”
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Induction of Gut Mucosal Immune Responses: Importance of Genetic Background and Th1/Th2 Cross‐Regulation by Kjerrulf, M, Grdic, D, Kopf, M, Lycke, N

“…The reciprocal regulation of T‐helper cell (Th) subsets is widely documented in various animal models of infectious diseases. In this study IFN‐γ/IL‐4 double…”
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CD8‐deficient mice exhibit augmented mucosal immune responses and intact adjuvant effects to cholera toxin by HÖRNQUIST, E., GRDÌC, D., MAK, T., LYCKE, N.

“…We used normal, CD4 and CD8 gene‐targeted mice to investigate the role of CD4+ and CD8+ T cells in the regulation of gut mucosal immune responses following…”
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Splenic Marginal Zone Dendritic Cells Mediate the Cholera Toxin Adjuvant Effect: Dependence on the ADP-Ribosyltransferase Activity of the Holotoxin by Grdic, Dubravka, Ekman, Lena, Schon, Karin, Lindgren, Kristina, Mattsson, Johan, Magnusson, Karl-Eric, Ricciardi-Castagnoli, Paola, Lycke, Nils

“…The in vivo mechanisms of action of most vaccine adjuvants are poorly understood. In this study, we present data in mice that reveal a series of critical…”
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Oral tolerance in CD8-knockout mice; Cholera toxin abrogates induction but cannot break established tolerance by Grdic, D

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Immune-Stimulating Complexes Induce an IL-12-Dependent Cascade of Innate Immune Responses by Smith, Rosemary E, Donachie, Anne M, Grdic, Dubravka, Lycke, Nils, Mowat, Allan McI

“…The development of subunit vaccines requires the use of adjuvants that act by stimulating components of the innate immune response. Immune-stimulating…”
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Lack of Local Suppression in Orally Tolerant CD8-Deficient Mice Reveals a Critical Regulatory Role of CD8+ T Cells in the Normal Gut Mucosa by Grdic, Dubravka, Hornquist, Elisabeth, Kjerrulf, Martin, Lycke, Nils Y

“…We found that feeding keyhole limpet hemocyanin (KLH) to CD8-deficient (CD8-/-) mice induced oral tolerance that was comparable in both magnitude and quality…”
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The mucosal adjuvant effects of cholera toxin and immune‐stimulating complexes differ in their requirement for IL‐12, indicating different pathways of action by Grdic, Dubravka, Smith, Rosemary, Donachie, Anne, Kjerrulf, Martin, Hörnquist, Elisabeth, Mowat, Allan, Lycke, Nils

“…Adjuvants that can improve mucosal vaccine efficacy are much warranted. In this comparative study between cholera toxin (CT) and immune‐stimulating complexes…”
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Oral vaccination with immune stimulating complexes by McI Mowat, Allan, Smith, Rosemary E, Donachie, Anne M, Furrie, Elizabeth, Grdic, Dubravka, Lycke, Nils

“…There is a need for non-living adjuvant vectors which will induce a full range of local and systemic immune responses to orally administered purified antigens…”
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Lack of local suppression in orally tolerant CD8-deficient mice reveals a critical regulatory role of CD8 super(+) T cells in the normal gut mucosa by Grdic, D, Hoernquist, E, Kjerrulf, M, Lycke, N Y

“…We found that feeding keyhole limpet hemocyanin (KLH) to CD8-deficient (CD8 super(-/-)) mice induced oral tolerance that was comparable in both magnitude and…”
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Oral tolerance in CD8-knockout mice; cholera toxin abrogates induction but cannot break established tolerance by Grdic, D., Hömquist, E., Kjerrulf, M., Lycke, N.

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Impaired mucosal IgA responses but intact oral tolerance in IFN-γ receptor deficient mice by Kjerrulf, M., Grdic, D., Vajdy, M., Lycke, N.

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