Search Results - "Graziano, M P"

Gastritis Cystica Profunda: A Rare Disease, a Challenging Diagnosis, and an Uncertain Malignant Potential: A Case Report and Review of the Literature by De Stefano, Francesca, Graziano, Giorgio M. P, Viganò, Jacopo, Mauro, Aurelio, Peloso, Andrea, Peverada, Jacopo, Fellegara, Raffaele, Vanoli, Alessandro, Faillace, Giuseppe G, Ansaloni, Luca

“…Gastritis cystica profunda (GCP) has been defined as a rare submucosal benign gastric lesion with cystic gland growth. Due to its unclear etiopathogenesis,…”
Get full text

Leptin increases energy expenditure and selectively promotes fat metabolism in ob/ob mice by Hwa, J.J, Fawzi, A.B, Graziano, M.P, Ghibaudi, L, Williams, P, Van Heek, M, Davis, H, Rudinski, M, Sybertz, E, Strader, C.D

“…Obesity occurs whenever energy intake exceeds energy expenditure. The ob gene product leptin is a potent anorectic agent when administered to ob/ob mice, but…”
Get full text

The family of G-protein-coupled receptors by Strader, C D, Fong, T M, Graziano, M P, Tota, M R

“…The family of G-protein-coupled receptors can be defined by their similar structural and functional characteristics. Although their primary sequences are quite…”
Get more information

Synthesis in Escherichia coli of GTPase-deficient mutants of Gsα by Graziano, M P, Gilman, A G

“…We have reduced the GTPase activity of the α subunit of Gs, the guanine nucleotide-binding regulatory protein that stimulates adenylyl cyclase, by introduction…”
Get full text

Stimulatory and inhibitory regulation of calcium-activated potassium channels by guanine nucleotide-binding proteins by Kume, H, Graziano, M.P, Kotlikoff, M.I

“…The regulation of membrane ion channels by guanine nucleotide-binding proteins (G proteins) has been described in numerous tissues. This regulation has been…”
Get full text

Niemann-Pick C1 like 1 Protein Is Critical for Intestinal Cholesterol Absorption by Altmann, Scott W., Davis, Harry R., Zhu, Li-ji, Yao, Xiaorui, Hoos, Lizbeth M., Tetzloff, Glen, Sai Prasad N. Iyer, Maguire, Maureen, Golovko, Andrei, Zeng, Ming, Wang, Luquan, Murgolo, Nicholas, Graziano, Michael P.

“…Dietary cholesterol consumption and intestinal cholesterol absorption contribute to plasma cholesterol levels, a risk factor for coronary heart disease. The…”
Get full text

Cellular actions of nociceptin: transduction mechanisms by Hawes, Brian E., Graziano, Michael P., Lambert, David G.

“…The recent identification of the nociceptin receptor-nociceptin system and the description of its role in nociceptive processing has produced numerous…”
Get full text

The Mouse GalR2 Galanin Receptor: Genomic Organization, cDNA Cloning, and Functional Characterization by Pang, Ling, Hashemi, Tanaz, Lee, Hu‐Jung J., Maguire, Maureen, Graziano, Michael P., Bayne, Marvin, Hawes, Brian, Wong, Gwendolyn, Wang, Suke

“…: The diverse physiological actions of galanin are thought to be mediated through activation of galanin receptors (GalRs). We report the genomic and cDNA…”
Get full text

The melanin-concentrating hormone receptor couples to multiple G proteins to activate diverse intracellular signaling pathways by Hawes, B E, Kil, E, Green, B, O'Neill, K, Fried, S, Graziano, M P

“…The receptor for melanin-concentrating hormone (MCH) was recently identified as the orphan G protein-coupled receptor SLC-1. In this study, a CHO cell line…”
Get full text

Nociceptin activation of the human ORL1 receptor expressed in Chinese hamster ovary cells : Functional homology with opioid receptors by FAWZI, A. B, ZHANG, H, WEIG, B, HAWES, B, GRAZIANO, M. P

“…Opioid receptor-like 1 (ORL1) receptor, a member of the superfamily of G-protein-coupled receptors has significant primary sequence homology to the mu-, delta-…”
Get full text

Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase by Graziano, M P, Casey, P J, Gilman, A G

“…Complementary DNAs that encode two forms of the alpha subunit (Gs alpha) of the guanine nucleotide-binding protein responsible for stimulation of adenylate…”
Get full text

Diet-induced obese mice develop peripheral, but not central, resistance to leptin by Van Heek, M, Compton, D S, France, C F, Tedesco, R P, Fawzi, A B, Graziano, M P, Sybertz, E J, Strader, C D, Davis, Jr, H R

“…Leptin administration reduces obesity in leptin-deficient ob/ob mice; its effects in obese humans, who have high circulating leptin levels, remain to be…”
Get full text

Cloning and expression of a human glucagon receptor by MacNeil, D J, Occi, J L, Hey, P J, Strader, C D, Graziano, M P

“…A human glucagon receptor has been cloned from human liver tissue. The 1578-bp cDNA clone encodes a protein of 477 amino acids with 82% identity to the rat…”
Get more information

Cloning and functional expression of a human glucagon-like peptide-1 receptor by Graziano, M P, Hey, P J, Borkowski, D, Chicchi, G G, Strader, C D

“…A human glucagon-like 1 peptide receptor has been cloned from the gastric tumor cell line HGT-1. The cDNA clone encodes a protein of 463 amino acids and is a…”
Get more information

Purification of milligram quantities of human leptin from recombinant E. coli by Fawzi, A B, Zhang, H, van Heek, M, Graziano, M P

“…Leptin, the product of the obese (ob) gene, is a 16 kilodalton protein secreted from adipose tissue. Restoration of leptin to obese ob/ob mice leads to…”
Get more information

Alterations in Receptor Activation and Divalent Cation Activation of Agonist Binding by Deletion of Intracellular Domains of the Glucagon Receptor by Chicchi, Gary G., Graziano, Michael P., Koch, Greg, Hey, Patricia, Sullivan, Kathleen, Vicario, Pasquale P., Cascieri, Margaret A.

“…Deletion of residues 252-259 within the putative second intracellular loop of the human glucagon receptor results in a protein with high affinity for glucagon…”
Get full text

Molecular characterization of the melanin-concentrating hormone/receptor complex: identification of critical residues involved in binding and activation by Macdonald, D, Murgolo, N, Zhang, R, Durkin, J P, Yao, X, Strader, C D, Graziano, M P

“…A molecular model of the human melanin-concentrating hormone (MCH) peptide was constructed and docked into a helical, bacteriorhodopsin-based model of the…”
Get more information

Fat cell beta-adrenergic receptor in the hypothyroid rat. Impaired interaction with the stimulatory regulatory component of adenylate cyclase by Malbon, C C, Graziano, M P, Johnson, G L

“…Fat cells from the hypothyroid rat fail to synthesize cyclic AMP in response to beta-adrenergic agonists, although possessing normal amounts of beta-adrenergic…”
Get full text

SCH-202676: An allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors by Fawzi, A B, Macdonald, D, Benbow, L L, Smith-Torhan, A, Zhang, H, Weig, B C, Ho, G, Tulshian, D, Linder, M E, Graziano, M P

“…A novel thiadiazole compound, SCH-202676 (N-(2,3-diphenyl-1,2, 4-thiadiazol-5-(2H)-ylidene)methanamine), has been identified as an inhibitor of both agonist…”
Get more information

Down-regulation of the Expression of the Obese Gene by an Antidiabetic Thiazolidinedione in Zucker Diabetic Fatty Rats and db/db Mice (∗) by Zhang, Bei, Graziano, Michael P., Doebber, Thomas W., Leibowitz, Mark D., White-Carrington, Sylvia, Szalkowski, Deborah M., Hey, Patricia J., Wu, Margaret, Cullinan, Catherine A., Bailey, Philip, Lollmann, Bettina, Frederich, Robert, Flier, Jeffrey S., Strader, Catherine D., Smith, Roy G.

“…Obese (ob) is a recently identified gene involved in the regulation of energy balance in the mouse. We report here that AD-5075, a potent thiazolidinedione…”
Get full text