Search Results - "Graziani, I"

Mild Method for Succinimide Hydrolysis on ADCs: Impact on ADC Potency, Stability, Exposure, and Efficacy by Tumey, L. Nathan, Charati, Manoj, He, Tao, Sousa, Eric, Ma, Dangshe, Han, Xiaogang, Clark, Tracey, Casavant, Jeff, Loganzo, Frank, Barletta, Frank, Lucas, Judy, Graziani, Edmund I

“…The stability of the connection between the antibody and the toxin can have a profound impact on ADC safety and efficacy. There has been increasing evidence in…”
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Diversity oriented biosynthesis via accelerated evolution of modular gene clusters by Wlodek, Aleksandra, Kendrew, Steve G., Coates, Nigel J., Hold, Adam, Pogwizd, Joanna, Rudder, Steven, Sheehan, Lesley S., Higginbotham, Sarah J., Stanley-Smith, Anna E., Warneck, Tony, Nur-E-Alam, Mohammad, Radzom, Markus, Martin, Christine J., Overvoorde, Lois, Samborskyy, Markiyan, Alt, Silke, Heine, Daniel, Carter, Guy T., Graziani, Edmund I., Koehn, Frank E., McDonald, Leonard, Alanine, Alexander, Rodríguez Sarmiento, Rosa María, Chao, Suzan Keen, Ratni, Hasane, Steward, Lucinda, Norville, Isobel H., Sarkar-Tyson, Mitali, Moss, Steven J., Leadlay, Peter F., Wilkinson, Barrie, Gregory, Matthew A.

“…Erythromycin, avermectin and rapamycin are clinically useful polyketide natural products produced on modular polyketide synthase multienzymes by an…”
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Sensitive, High Throughput Detection of Proteins in Individual, Surfactant-Stabilized Picoliter Droplets Using Nanoelectrospray Ionization Mass Spectrometry by Smith, Clive A, Li, Xin, Mize, Todd H, Sharpe, Timothy D, Graziani, Edmund I, Abell, Chris, Huck, Wilhelm T. S

“…Droplet-based fluidics is emerging as a powerful platform for single cell analysis, directed evolution of enzymes, and high throughput screening studies. Due…”
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Multivalent peptidic linker enables identification of preferred sites of conjugation for a potent thialanstatin antibody drug conjugate by Puthenveetil, Sujiet, He, Haiyin, Loganzo, Frank, Musto, Sylvia, Teske, Jesse, Green, Michael, Tan, Xingzhi, Hosselet, Christine, Lucas, Judy, Tumey, L Nathan, Sapra, Puja, Subramanyam, Chakrapani, O'Donnell, Christopher J, Graziani, Edmund I

“…Antibody drug conjugates (ADCs) are no longer an unknown entity in the field of cancer therapy with the success of marketed ADCs like ADCETRIS and KADCYLA and…”
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Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody–Drug Conjugates by Ratnayake, Anokha S, Chang, Li-ping, Tumey, L. Nathan, Loganzo, Frank, Chemler, Joseph A, Wagenaar, Melissa, Musto, Sylvia, Li, Fengping, Janso, Jeffrey E, Ballard, T. Eric, Rago, Brian, Steele, Greg L, Ding, WeiDong, Feng, Xidong, Hosselet, Christine, Buklan, Vlad, Lucas, Judy, Koehn, Frank E, O’Donnell, Christopher J, Graziani, Edmund I

“…A potent class of DNA-damaging agents, natural product bis-intercalator depsipeptides (NPBIDs), was evaluated as ultrapotent payloads for use in antibody–drug…”
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trans-Resveratrol induces apoptosis in human breast cancer cells MCF-7 by the activation of MAP kinases pathways by Filomeni, G, Graziani, I, Rotilio, G, Ciriolo, M R

“…Polyphenols represent a large class of plant-derived molecules with a general chemical structure that act as potent free radical scavengers. They have long…”
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Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities by Ruan, Benfang, Pong, Kevin, Jow, Flora, Bowlby, Mark, Crozier, Robert A, Liu, Danni, Liang, Shi, Chen, Yi, Mercado, Mary Lynn, Feng, Xidong, Bennett, Frann, von Schack, David, McDonald, Leonard, Zaleska, Margaret M, Wood, Andrew, Reinhart, Peter H, Magolda, Ronald L, Skotnicki, Jerauld, Pangalos, Menelas N, Koehn, Frank E, Carter, Guy T, Abou-Gharbia, Magid, Graziani, Edmund I

“…Rapamycin is an immunosuppressive immunophilin ligand reported as having neurotrophic activity. We show that modification of rapamycin at the mammalian target…”
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Overcoming Amino-Nogo-induced Inhibition of Cell Spreading and Neurite Outgrowth by 12-O-Tetradecanoylphorbol-13-acetate-type Tumor Promoters by Deng, Kangwen, Gao, Ying, Cao, Zixuan, Graziani, Edmund I., Wood, Andrew, Doherty, Patrick, Walsh, Frank S.

“…The N-terminal domain of NogoA, called amino-Nogo, inhibits axonal outgrowth and cell spreading via a largely unknown mechanism. In the present study, we show…”
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Amphotericin B, identified from a natural product screen, antagonizes CNS inhibitors to promote axon growth via activation of an Akt pathway in neurons by Gao, Ying, Deng, Kangwen, Cao, Zixuan, Graziani, Edmund I, Gilbert, Adam M, Koehn, Frank E, Wood, Andrew, Doherty, Patrick, Walsh, Frank S

“…J. Neurochem. (2010) 113, 1331-1342. One of the major barriers to successful axon regeneration in the adult CNS is the presence of inhibitory molecules that…”
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Recent advances in the chemistry, biosynthesis and pharmacology of rapamycin analogs by Graziani, Edmund I

“…Covering: 2003 to 2008. In the period 1998 to 2003, a number of reviews have appeared evaluating the potential of rapamycin and other immunophilin ligands as…”
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Septocylindrins A and B: Peptaibols Produced by the Terrestrial Fungus Septocylindrium sp. LL-Z1518 by Summers, M.Y, Kong, F, Feng, X, Siegel, M.M, Janso, J.E, Graziani, E.I, Carter, G.T

“…Two new peptaibols, septocylindrin A (1) and septocylindrin B (2), related to the well-studied membrane-channel-forming peptaibol alamethicin, were obtained…”
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Production of Novel Rapamycin Analogs by Precursor-Directed Biosynthesis by Ritacco, Frank V, Graziani, Edmund I, Summers, Mia Y, Zabriskie, T. Mark, Yu, Ker, Bernan, Valerie S, Carter, Guy T, Greenstein, Michael

“…The natural product rapamycin, produced during fermentation by Streptomyces hygroscopicus, is known for its potent antifungal, immunosuppressive, and…”
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Unmasking the True Identity of Rapamycin’s Minor Conformer by Crull, Emily B., Jain, Ajay N., Hawkins, Paul C. D., Cleves, Ann E., Graziani, Edmund I., Williamson, R. Thomas

“…Rapamycin, a well-known macrocyclic natural product with myriad biological activities, has been the subject of intense study since its first isolation and…”
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PF-06804103, A Site-specific Anti-HER2 Antibody–Drug Conjugate for the Treatment of HER2-expressing Breast, Gastric, and Lung Cancers by Graziani, Edmund I., Sung, Matthew, Ma, Dangshe, Narayanan, Bitha, Marquette, Kimberly, Puthenveetil, Sujiet, Tumey, L. Nathan, Bikker, Jack, Casavant, Jeffrey, Bennett, Eric M., Charati, Manoj B., Golas, Jonathon, Hosselet, Christine, Rohde, Cynthia M., Hu, George, Guffroy, Magali, Falahatpisheh, Hadi, Finkelstein, Martin, Clark, Tracey, Barletta, Frank, Tchistiakova, Lioudmila, Lucas, Judy, Rosfjord, Edward, Loganzo, Frank, O'Donnell, Christopher J., Gerber, Hans-Peter, Sapra, Puja

“…The approval of ado-trastuzumab emtansine (T-DM1) in HER2+ metastatic breast cancer validated HER2 as a target for HER2-specific antibody–drug conjugates…”
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Mannopeptimycins, Novel Antibacterial Glycopeptides from Streptomyces hygroscopicus, LL-AC98 by HE, Haiyin, WILLIAMSON, R. Thomas, SHEN, Bo, GRAZIANI, Edmund I., YANG, Hui Y., SAKYA, Subas M., PETERSEN, Pete J., CARTER, Guy T.

“…A series of novel antibiotics with activity against methicillin-resistant staphylococci and vancomycin-resistant enterococci has been purified, and their…”
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Phaeochromycins A-E, anti-inflammatory polyketides isolated from the soil actinomycete Streptomyces phaeochromogenes LL-P018 by Graziani, E.I, Ritacco, F.V, Bernan, V.S, Telliez, J.B

“…Five new polyketide metabolites, phaeochromycins A-E (1-5), were isolated from an actinomycete designated Streptomyces phaeochromogenes LL-P018, cultured from…”
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3-Normeridamycin: A Potent Non-Immunosuppressive Immunophilin Ligand is Neuroprotective in Dopaminergic Neurons by Summers, Mia Y, Leighton, Margaret, Liu, Danni, Pong, Kevin, Graziani, Edmund I

“…3-Normeridamycin (1), isolated from fermentation extracts of the soil actinomycete Streptomyces sp. LL-C31037, demonstrated potent neuroprotective activity…”
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Natural Product Splicing Inhibitors: A New Class of Antibody–Drug Conjugate (ADC) Payloads by Puthenveetil, Sujiet, Loganzo, Frank, He, Haiyin, Dirico, Ken, Green, Michael, Teske, Jesse, Musto, Sylvia, Clark, Tracey, Rago, Brian, Koehn, Frank, Veneziale, Robert, Falahaptisheh, Hadi, Han, Xiaogang, Barletta, Frank, Lucas, Judy, Subramanyam, Chakrapani, O’Donnell, Christopher J, Tumey, L. Nathan, Sapra, Puja, Gerber, Hans Peter, Ma, Dangshe, Graziani, Edmund I

“…There is a considerable ongoing work to identify new cytotoxic payloads that are appropriate for antibody-based delivery, acting via mechanisms beyond DNA…”
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Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates by Tumey, L. Nathan, Li, Fengping, Rago, Brian, Han, Xiaogang, Loganzo, Frank, Musto, Sylvia, Graziani, Edmund I., Puthenveetil, Sujiet, Casavant, Jeffrey, Marquette, Kimberly, Clark, Tracey, Bikker, Jack, Bennett, Eric M., Barletta, Frank, Piche-Nicholas, Nicole, Tam, Amy, O’Donnell, Christopher J., Gerber, Hans Peter, Tchistiakova, Lioudmila

“…As the antibody drug conjugate (ADC) community continues to shift towards site-specific conjugation technology, there is a growing need to understand how the…”
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Use of translational modeling and simulation for quantitative comparison of PF-06804103, a new generation HER2 ADC, with Trastuzumab-DM1 by Betts, Alison, Clark, Tracey, Jasper, Paul, Tolsma, John, van der Graaf, Piet H., Graziani, Edmund I., Rosfjord, Edward, Sung, Matthew, Ma, Dangshe, Barletta, Frank

“…A modeling and simulation approach was used for quantitative comparison of a new generation HER2 antibody drug conjugate (ADC, PF-06804103) with…”
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