Search Results - "Gray Shaw"

Tandem P-selectin glycoprotein ligand immunoglobulin prevents lung vaso-occlusion in sickle cell disease mice by Vats, Ravi, Tutuncuoglu, Egemen, Pradhan-Sundd, Tirthadipa, Tejero, Jesus, Shaw, Gray D., Sundd, Prithu

“…•Intravenous administration of hemoglobin triggers lung vaso-occlusion in SCD mice.•Hemoglobin triggers sequestration of neutrophil–platelet aggregates in lung…”
Get full text

Arterial Platelet Adhesion in Atherosclerosis-Prone Arteries of Obese, Insulin-Resistant Nonhuman Primates by Brown, Eran, Ozawa, Koya, Moccetti, Federico, Vinson, Amanda, Hodovan, James, Nguyen, The Anh, Bader, Lindsay, López, José A, Kievit, Paul, Shaw, Gray D, Chung, Dominic W, Osborn, Warren, Fu, Xiaoyun, Chen, Junmei, Lindner, Jonathan R

“…Background Platelet-endothelial interactions are thought to contribute to early atherogenesis. These interactions are potentiated by oxidative stress. We used…”
Get full text

Glycoprotein Ibα inhibitor (CCP-224) prevents neutrophil-platelet aggregation in sickle cell disease by Jimenez, Maritza A., Novelli, Enrico M., Shaw, Gray D., Sundd, Prithu

“…•CCP-224 attenuates neutrophil-platelet aggregation in SCD patient blood.•CCP-224 has the potential to prevent vaso-occlusion in SCD patients…”
Get full text

The von Willebrand factor antagonist (GPG-290) prevents coronary thrombosis without prolongation of bleeding time by Wadanoli, Michael, Sako, Dianne, Shaw, Gray D, Schaub, Robert G, Wang, Qin, Tchernychev, Boris, Xu, Jin, Porter, Thomas J, Huang, Qinheng

“…The interaction between von Willebrand factor (VWF) and platelet glycoprotein Ibalpha (GPIbalpha) is a critical step that allows platelet adhesion, activation…”
Get more information

Discovery of 2-[1-(4-Chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic Acid (PSI-421), a P-Selectin Inhibitor with Improved Pharmacokinetic Properties and Oral Efficacy in Models of Vascular Injury by Huang, Adrian, Moretto, Alessandro, Janz, Kristin, Lowe, Michael, Bedard, Patricia W, Tam, Steve, Di, Li, Clerin, Valerie, Sushkova, Natalia, Tchernychev, Boris, Tsao, Desiree H. H, Keith, James C, Shaw, Gray D, Schaub, Robert G, Wang, Qin, Kaila, Neelu

“…Previously, we reported the discovery of PSI-697 (1a), a C-2 benzyl substituted quinoline salicylic acid-based P-selectin inhibitor. It is active in a variety…”
Get full text

2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic Acid (PSI-697):  Identification of a Clinical Candidate from the Quinoline Salicylic Acid Series of P-Selectin Antagonists by Kaila, Neelu, Janz, Kristin, Huang, Adrian, Moretto, Alessandro, DeBernardo, Silvano, Bedard, Patricia W, Tam, Steve, Clerin, Valerie, Keith, James C, Tsao, Desirée H. H, Sushkova, Natalia, Shaw, Gray D, Camphausen, Raymond T, Schaub, Robert G, Wang, Qin

“…P-selectin-PSGL-1 interaction causes rolling of leukocytes on the endothelial cell surface, which subsequently leads to firm adherence and leukocyte…”
Get full text

Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis by Bedard, Patricia W, Clerin, Valerie, Sushkova, Natalia, Tchernychev, Boris, Antrilli, Thomas, Resmini, Christine, Keith, Jr, James C, Hennan, James K, Kaila, Neelu, Debernardo, Silvano, Janz, Kristin, Wang, Qin, Crandall, David L, Schaub, Robert G, Shaw, Gray D, Carter, Laura L

“…P-selectin plays a significant and well documented role in vascular disease by mediating leukocyte and platelet rolling and adhesion. This study characterizes…”
Get more information

SLIC-1/sorting nexin 20: A novel sorting nexin that directs subcellular distribution of PSGL-1 by Schaff, Ulrich Y, Shih, Heather H, Lorenz, Meike, Sako, Dianne, Kriz, Ron, Milarski, Kim, Bates, Brian, Tchernychev, Boris, Shaw, Gray D, Simon, Scott I

“…P-Selectin glycoprotein ligand-1 (PSGL-1) is a mucin-like glycoprotein expressed on the surface of leukocytes that serves as the major ligand for the selectin…”
Get full text

Pharmacologic inhibition of platelet vWF-GPIb alpha interaction prevents coronary artery thrombosis by Hennan, James K, Swillo, Robert E, Morgan, Gwen A, Leik, Courtney E, Brooks, Jonathan M, Shaw, Gray D, Schaub, Robert G, Crandall, David L, Vlasuk, George P

“…Under high shear arterial blood flow von Willebrand Factor (vWF) binds the platelet receptor glycoprotein (GP) Ibalpha, leading to platelet adhesion,…”
Get more information

Decreased venous thrombosis with an oral inhibitor of P selectin by Myers, Daniel D., Rectenwald, John E., Bedard, Patricia W., Kaila, Neelu, Shaw, Gray D., Schaub, Robert G., Farris, Diana M., Hawley, Angela E., Wrobleski, Shirley K., Henke, Peter K., Wakefield, Thomas W.

“…P-selectin inhibition with protein therapeutics such as antibodies or soluble ligands given intravenously can decrease thrombosis in a mouse ligation model of…”
Get full text

Identification of Peptide Antagonists to Glycoprotein Ibα That Selectively Inhibit von Willebrand Factor Dependent Platelet Aggregation by Benard, Susan Adam, Smith, Thomas M, Cunningham, Kristina, Jacob, Jaison, DeSilva, Thamara, Lin, Laura, Shaw, Gray D, Kriz, Ron, Kelleher, Kerry S

“…GPIbα is an integral membrane protein of the GPIb-IX-V complex found on the platelet surface that interacts with the A1 domain of von Willebrand factor…”
Get full text

Molecular Characterization of Rat Leukocyte P-Selectin Glycoprotein Ligand-1 and Effect of Its Blockade: Protection from Ischemia-Reperfusion Injury in Liver Transplantation by Tsuchihashi, Sei-ichiro, Fondevila, Constantino, Shaw, Gray D, Lorenz, Meike, Marquette, Kimberly, Benard, Susan, Shen, Xiu-Da, Ke, Bibo, Busuttil, Ronald W, Kupiec-Weglinski, Jerzy W

“…P-selectin glycoprotein ligand-1 (PSGL-1) mediates the initial tethering of leukocytes to activated platelets and endothelium. We report molecular cloning and…”
Get full text

A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation by Shaw, G, Kamen, R

“…The mRNAs of transiently expressed genes frequently contain an AU-rich sequence in the 3' untranslated region. We introduced a 51 nucleotide AT sequence from a…”
Get more information

Expression cloning of a functional glycoprotein ligand for P-selectin by Sako, D, Chang, X J, Barone, K M, Vachino, G, White, H M, Shaw, G, Veldman, G M, Bean, K M, Ahern, T J, Furie, B

“…The initial adhesive interactions between circulating leukocytes and endothelia are mediated, in part, by P-selectin. We now report the expression cloning of a…”
Get more information

Normalization of brain death-induced injury to rat renal allografts by recombinant soluble P-selectin glycoprotein ligand by GASSER, Martin, WAAGA, Ana Maria, HOLTHE, Joana E. Kist-Van, LENHARD, Susanne M, LASKOWSKI, Igor, SHAW, Gray D, HANCOCK, Wayne W, TILNEY, Nicholas L

“…Donor brain death has been considered a significant risk factor for both early and late organ allograft dysfunction. This central injury not only evokes an…”
Get full text

P‐Selectin Glycoprotein Ligand‐1 (rPSGL‐Ig)‐Mediated Blockade of CD62 Selectin Molecules Protects Rat Steatotic Liver Grafts from Ischemia/Reperfusion Injury by Amersi, Farin, Farmer, Douglas G., Shaw, Gray D., Kato, Hirohisa, Coito, Ana J., Kaldas, Fady, Zhao, Delai, Lassman, Charles R., Melinek, Judy, Ma, Jeffrey, Volk, Hans‐Dieter, Kupiec‐Weglinski, Jerzy W., Busuttil, Ronald W.

“…We examined the effects of early blockade of CD62 selectin‐mediated adhesive interactions in steatotic rat liver models of ex vivo cold ischemia followed by…”
Get full text

CD62 blockade with P-selectin glycoprotein ligand-immunoglobulin fusion protein reduces ischemia-reperfusion injury after rat intestinal transplantation by FARMER, Douglas G, SHEN, Xiu-Da, MCDIARMID, Sue V, BUSUTTIL, Ronald W, KUPIEC-WEGLINSKI, Jerzy, AMERSI, Farin, ANSELMO, Dean, MA, Jeffrey P, BIBO KE, FENG GAO, DRY, Sarah, FERNANDEZ, Susan, SHAW, Gray D

“…Intestinal transplantation (ITx) is severely limited by ischemia-reperfusion (I/R) injury. This study investigates I/R injury and ameliorates its consequences…”
Get full text

Selectin Blockade Plus Therapy with Low‐Dose Sirolimus and Cyclosporin A Prevent Brain Death‐Induced Renal Allograft Dysfunction by Gasser, Martin, Waaga‐Gasser, Ana Maria, Grimm, Michael W., Grimm, Martin R., Lenhard, Miriam S., Kist‐van Holthe, Joana E., Laskowski, Igor, Shaw, Gray D., Thiede, Arnulf, Hancock, Wayne W., Tilney, Nicholas L.

“…Both antigen‐dependent and ‐independent factors influence long‐term organ allograft function and survival. Brain death (BD), a significant antigen‐independent,…”
Get full text

Translational Blockade Imposed by Cytokine-Derived UA-Rich Sequences by Kruys, Véronique, Marinx, Olivier, Shaw, Gray, Deschamps, Jacqueline, Huez, George

“…The messenger RNAs specifying certain proteins involved in the inflammatory response and certain oncoproteins contain a conserved UA-rich sequence in the…”
Get full text

A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding by Sako, Dianne, Comess, Kenneth M., Barone, Karen M., Camphausen, Raymond T., Cumming, Dale A., Shaw, Gray D.

“…P-selectin glycoprotein ligand 1 (PSGL-1) is a mucin-like glycoprotein expressed on the surface of myeloid cells and serves as the high affinity…”
Get full text