Search Results - "Gray, Simon"

The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection by Staron, Matthew M., Gray, Simon M., Marshall, Heather D., Parish, Ian A., Chen, Jonathan H., Perry, Curtis J., Cui, Guoliang, Li, Ming O., Kaech, Susan M.

“…Protein kinase B (also known as AKT) and the mechanistic target of rapamycin (mTOR) are central regulators of T cell differentiation, proliferation,…”
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IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity by Cui, Guoliang, Staron, Matthew M., Gray, Simon M., Ho, Ping-Chih, Amezquita, Robert A., Wu, Jingxia, Kaech, Susan M.

“…Memory T cells are critical for long-term immunity against reinfection and require interleukin-7 (IL-7), but the mechanisms by which IL-7 controls memory…”
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Polycomb Repressive Complex 2-Mediated Chromatin Repression Guides Effector CD8+ T Cell Terminal Differentiation and Loss of Multipotency by Gray, Simon M., Amezquita, Robert A., Guan, Tianxia, Kleinstein, Steven H., Kaech, Susan M.

“…Understanding immunological memory formation depends on elucidating how multipotent memory precursor (MP) cells maintain developmental plasticity and longevity…”
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The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells by Ray, John P., Staron, Matthew M., Shyer, Justin A., Ho, Ping-Chih, Marshall, Heather D., Gray, Simon M., Laidlaw, Brian J., Araki, Koichi, Ahmed, Rafi, Kaech, Susan M., Craft, Joe

“…The differentiation of CD4+ helper T cell subsets with diverse effector functions is accompanied by changes in metabolism required to meet their bioenergetic…”
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The interface between transcriptional and epigenetic control of effector and memory CD8+ T-cell differentiation by Gray, Simon M., Kaech, Susan M., Staron, Matthew M.

“…Summary Immunity to many intracellular pathogens requires the proliferation, differentiation, and function of CD8+ cytotoxic T lymphocytes (CTLs). While the…”
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Systematic Review of Proinflammatory Cytokines in Obsessive-Compulsive Disorder by Gray, Simon M., Bloch, Michael H.

“…Several studies have examined levels of proinflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6. This meta-analysis was…”
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Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells by Laidlaw, Brian J, Cui, Weiguo, Amezquita, Robert A, Gray, Simon M, Guan, Tianxia, Lu, Yisi, Kobayashi, Yasushi, Flavell, Richard A, Kleinstein, Steven H, Craft, Joe, Kaech, Susan M

“…The precise factors that control effective memory formation by T cells are unclear. Kaech et al . demonstrate that regulatory T cell–produced IL-10 is critical…”
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ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells by Boddupalli, Chandra Sekhar, Nair, Shiny, Gray, Simon M, Nowyhed, Heba N, Verma, Rakesh, Gibson, Joanna A, Abraham, Clara, Narayan, Deepak, Vasquez, Juan, Hedrick, Catherine C, Flavell, Richard A, Dhodapkar, Kavita M, Kaech, Susan M, Dhodapkar, Madhav V

“…Immune surveillance in tissues is mediated by a long-lived subset of tissue-resident memory T cells (Trm cells). A putative subset of tissue-resident…”
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Immune checkpoint inhibitor-induced cholangitis-a three-case series by Gray, Simon, Santamaria, Nuria, Olsson-Brown, Anna

“…Over the last decade, immune checkpoint inhibitors (ICIs) have dramatically improved the systemic treatment of multiple solid tumour types. However, they can…”
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Non-invasive cardiac stress studies may not offer significant benefit in pre-kidney transplant evaluation: A retrospective cohort study by Kanigicherla, Durga Anil K, Bhogal, Talvinder, Stocking, Katie, Chinnadurai, Rajkumar, Gray, Simon, Javed, Saad, Fortune, Christien, Augustine, Titus, Kalra, Philip A

“…Screening with cardiac non-invasive stress studies (NISS) prior to listing for kidney transplantation can help in identifying treatable coronary disease and is…”
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Mouse adaptation of human inflammatory bowel diseases microbiota enhances colonization efficiency and alters microbiome aggressiveness depending on the recipient colonic inflammatory environment by Gray, Simon M, Moss, Anh D, Herzog, Jeremy W, Kashiwagi, Saori, Liu, Bo, Young, Jacqueline B, Sun, Shan, Bhatt, Aadra P, Fodor, Anthony A, Balfour Sartor, R

“…Understanding the cause vs consequence relationship of gut inflammation and microbial dysbiosis in inflammatory bowel diseases (IBD) requires a reproducible…”
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Low Temperature Hot Corrosion Screening of Single Crystal Superalloys by Smialek, James L, Gray, Simon

“…Single crystal superalloys were screened in Type II molten (Na,K)-sulfate hot corrosion re-coat tests in air +300 ppm SO₂ at 700 °C. They exhibited large 20⁻40…”
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A bi-objective decision support tool based on system dynamics and discrete event modelling for sustainable supply chain by Yu, Jia, Hieu, Trung, Gray, Simon, Encinas-Oropesa, Adriana

“…Based on the development trend of sustainable concepts and the implement ability of composites combined with Agave Bagasse Fibre (ABF) and Polyethylene…”
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A new approach to improve the hemodynamic assessment of cardiac function independent of respiratory influence by Ogilvie, Leslie M., Edgett, Brittany A., Gray, Simon, Al-Mufty, Sally, Huber, Jason S., Brunt, Keith R., Simpson, Jeremy A.

“…Cardiovascular and respiratory systems are anatomically and functionally linked; inspiration produces negative intrathoracic pressures that act on the heart…”
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Effects of surface hardening by laser shock peening and shot peening on a nickel-based single-crystal superalloy CMSX-4 by Hakeem, Aabid Husen, Morar, Nicolau I, Dawson, Karl, Tatlock, Gordon J, Gibson, Grant J, Gray, Simon

“…Abstract Improving the expected life of nickel-based single-crystal superalloy turbine components by surface hardening treatments including laser shock peening…”
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Mock MRI: reducing the need for anaesthesia in children by Carter, Amanda J., Greer, Mary-Louise C., Gray, Simon E., Ware, Robert S.

“…Background With a longer waiting list for paediatric MRI performed under general anaesthesia (GA) and considering safety concerns, the Royal Children’s…”
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Disambiguate: An open-source application for disambiguating two species in next generation sequencing data from grafted samples [version 1; peer review: 2 approved, 1 approved with reservations] by Ahdesmäki, Miika J, Gray, Simon R, Johnson, Justin H, Lai, Zhongwu

“…Grafting of cell lines and primary tumours is a crucial step in the drug development process between cell line studies and clinical trials. Disambiguate is a…”
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Machine Learning Applied to Identify Corrosive Environmental Conditions by Lee, HsinYen, Gray, Simon, Zhao, Yifan, Castelluccio, Gustavo M.

“…The reliability of turbine engines depends significantly on the environment experienced during flight. Air humidity, corrosive contaminant substances, and high…”
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Super Secrets of the Successful Jobseeker: Everything You Need to Know About Finding a Job in Difficult Times by Gray, Simon

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Occupational exposure of healthcare workers to COVID-19 and infection prevention control measures in haemodialysis facilities in North West of England by Gray, Simon, Clough, Toni, Mcgee, Yvonne, Murphy, Tracey, Donne, Rosemary, Poulikakos, Dimitrios

“…COVID-19 infection rates in haemodialysis (HD) facilities are extremely high and are attributed to the high burden of comorbidities of HD patients coupled with…”
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