Search Results - "Gray, Sarah L."

The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation by PAYNE, Victoria A, GRIMSEY, Neil, TUTHILL, Antoinette, VIRTUE, Sam, GRAY, Sarah L, DALLA NORA, Edoardo, SEMPLE, Robert K, O'RAHILLY, Stephen, ROCHFORD, Justin J

“…The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation Victoria A. Payne 1 , Neil Grimsey 2 , Antoinette Tuthill 1 ,…”
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Contribution of thermogenic mechanisms by male and female mice lacking pituitary adenylate cyclase-activating polypeptide in response to cold acclimation by Filatov, Ekaterina, Short, Landon I, Forster, Maeghan A M, Harris, Simon S, Schien, Erik N, Hughes, Malcolm C, Cline, Daemon L, Appleby, Colin J, Gray, Sarah L

“…Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide critical to the regulation of the stress response, including having a role in…”
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PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism by Medina-Gomez, Gema, Gray, Sarah L, Yetukuri, Laxman, Shimomura, Kenju, Virtue, Sam, Campbell, Mark, Curtis, R Keira, Jimenez-Linan, Mercedes, Blount, Margaret, Yeo, Giles S H, Lopez, Miguel, Seppänen-Laakso, Tuulikki, Ashcroft, Frances M, Oresic, Matej, Vidal-Puig, Antonio

“…Peroxisome proliferator activated receptor gamma 2 (PPARg2) is the nutritionally regulated isoform of PPARg. Ablation of PPARg2 in the ob/ob background,…”
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Disruption of Hepatic Leptin Signaling Protects Mice From Age- and Diet-Related Glucose Intolerance by HUYNH, Frank K, LEVI, Jasna, DENROCHE, Heather C, GRAY, Sarah L, VOSHOL, Peter J, NEUMANN, Ursula H, SPECK, Madeleine, CHUA, Streamson C, COVEY, Scott D, KIEFFER, Timothy J

“…The liver plays a critical role in integrating and controlling glucose metabolism. Thus, it is important that the liver receive and react to signals from other…”
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Acute Disruption of Leptin Signaling in Vivo Leads to Increased Insulin Levels and Insulin Resistance by Levi, Jasna, Gray, Sarah L, Speck, Madeleine, Huynh, Frank K, Babich, Sandra L, Gibson, William T, Kieffer, Timothy J

“…Leptin, an adipocyte-derived hormone, plays an essential role in the maintenance of normal body weight and energy expenditure, as well as glucose homeostasis…”
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PACAP is essential for the adaptive thermogenic response of brown adipose tissue to cold exposure by Diané, Abdoulaye, Nikolic, Nikolina, Rudecki, Alexander P, King, Shannon M, Bowie, Drew J, Gray, Sarah L

“…Pituitary adenylate cyclase-activating polypeptide (PACAP) is a widely distributed neuropeptide that acts as a neurotransmitter, neuromodulator, neurotropic…”
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Impact of sex on microvascular reactivity in a murine model of diet-induced obesity and insulin resistance by Sidsworth, Danielle A., Sellers, Stephanie L., Reutens-Hernandez, Jennifer P., Dunn, Elizabeth A., Gray, Sarah L., Payne, Geoffrey W.

“…The association of obesity with cardiovascular disease is well established. However, the interplay of obesity and vascular dysfunction in peripheral tissues…”
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Leptin Deficiency Unmasks the Deleterious Effects of Impaired Peroxisome Proliferator–Activated Receptor γ Function (P465L PPARγ) in Mice by Gray, Sarah L., Nora, Edoardo Dalla, Grosse, Johannes, Manieri, Monia, Stoeger, Tobias, Medina-Gomez, Gema, Burling, Keith, Wattler, Sigrid, Russ, Andreas, Yeo, Giles S.H., Chatterjee, V. Krishna, O’Rahilly, Stephen, Voshol, Peter J., Cinti, Saverio, Vidal-Puig, Antonio

“…Leptin Deficiency Unmasks the Deleterious Effects of Impaired Peroxisome Proliferator–Activated Receptor γ Function (P465L PPARγ) in Mice Sarah L. Gray 1 ,…”
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Feeding and Metabolism in Mice Lacking Pituitary Adenylate Cyclase-Activating Polypeptide by Adams, Bruce A, Gray, Sarah L, Isaac, Emma R, Bianco, Antonio C, Vidal-Puig, Antonio J, Sherwood, Nancy M

“…Disruption of the pituitary adenylate cyclase-activating polypeptide (PACAP) gene in mice has demonstrated a role for this highly conserved neuropeptide in the…”
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Altered cerebellar development in mice lacking pituitary adenylate cyclase-activating polypeptide by Allais, Aurélie, Burel, Delphine, Isaac, Emma R., Gray, Sarah L., Basille, Magali, Ravni, Aurélia, Sherwood, Nancy M., Vaudry, Hubert, Gonzalez, Bruno J.

“…Previous studies have demonstrated that pituitary adenylate cyclase‐activating polypeptide (PACAP) exerts trophic effects during neurodevelopment. In…”
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PACAP in the Defense of Energy Homeostasis by Rudecki, Alexander P, Gray, Sarah L

“…The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) mediates diverse physiology from neuroprotection to thermoregulation. PACAP is well…”
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Reference gene recommendations and PACAP receptor expression in murine sympathetic ganglia of the autonomic nervous system that innervate adipose tissues after chronic cold exposure by Pandher, Parleen K., Rahim, Yamna, Timms, Katherine P., Filatov, Ekaterina, Short, Landon I., Gray, Sarah L.

“…Pituitary adenylate cyclase‐activating polypeptide (PACAP) is an important regulator of the stress response in mammals, influencing both the…”
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Adipose Tissue Expandability in the Maintenance of Metabolic Homeostasis by Gray, Sarah L., Vidal-Puig, Antonio J.

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Hyperinsulinemia Precedes Insulin Resistance in Mice Lacking Pancreatic β-Cell Leptin Signaling by Gray, Sarah L, Donald, Christine, Jetha, Arif, Covey, Scott D, Kieffer, Timothy J

“…The adipocyte hormone leptin acts centrally and peripherally to regulate body weight and glucose homeostasis. The pancreatic β-cell has been shown to be a key…”
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Adipose Tissue Expression of PACAP, VIP, and Their Receptors in Response to Cold Stress by Cline, Daemon L., Short, Landon I., Forster, Maeghan A. M., Gray, Sarah L.

“…Obesity arises from disrupted energy balance and is caused by chronically higher energy intake compared to expenditure via basal metabolic rate, exercise, and…”
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Adipose Tissue Expandability in the Maintenance of Metabolic Homeostasis by Gray, S.L, Vidal-Puig, A.J

“…Adipose tissue expands to accommodate increased lipid through hypertrophy of existing adipocytes and by initiating differentiation of preadipocytes. The…”
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Chronic Exposure to PCBs (Aroclor 1254) Exacerbates Obesity-Induced Insulin Resistance and Hyperinsulinemia in Mice by Gray, Sarah L., Shaw, Alyssa C., Gagne, Anthony X., Chan, Hing Man

“…Evidence from recent epidemiological studies has emerged implicating exposure to environmental toxicants as a novel risk factor for the development of type 2…”
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AAV8 Ins1-Cre can produce efficient β-cell recombination but requires consideration of off-target effects by Ramzy, Adam, Tudurí, Eva, Glavas, Maria M., Baker, Robert K., Mojibian, Majid, Fox, Jessica K., O’Dwyer, Shannon M., Dai, Derek, Hu, Xiaoke, Denroche, Heather C., Edeer, Nazde, Gray, Sarah L., Verchere, Cameron B., Johnson, James D., Kieffer, Timothy J.

“…In vivo genetic manipulation is used to study the impact of gene deletion or re-expression on β-cell function and organism physiology. Cre-LoxP is a system…”
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Melanotan II, a melanocortin agonist, partially rescues the impaired thermogenic capacity of pituitary adenylate cyclase‐activating polypeptide deficient mice by McMillan, Thecla Rae, Forster, Maeghan A. M., Short, Landon I., Rudecki, Alexander P., Cline, Daemon L., Gray, Sarah L.

“…New Findings What is the central question of this study? Can chronic treatment of pituitary adenylate cyclase‐activating polypeptide (PACAP) deficient mice…”
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A Family with Severe Insulin Resistance and Diabetes Due to a Mutation in AKT2 by George, Stella, Rochford, Justin J., Wolfrum, Christian, Gray, Sarah L., Schinner, Sven, Wilson, Jenny C., Soos, Maria A., Murgatroyd, Peter R., Williams, Rachel M., Acerini, Carlo L., Dunger, David B., Barford, David, Umpleby, A. Margot, Wareham, Nicholas J., Davies, Huw Alban, Schafer, Alan J., Stoffel, Markus, O'Rahilly, Stephen, Barroso, Inês

“…Inherited defects in signaling pathways downstream of the insulin receptor have long been suggested to contribute to human type 2 diabetes mellitus. Here we…”
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