Search Results - "Gray, Ryan S."

Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity by Gray, Ryan S., Roszko, Isabelle, Solnica-Krezel, Lilianna

“…Planar cell polarization entails establishment of cellular asymmetries within the tissue plane. An evolutionarily conserved planar cell polarity (PCP)…”
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ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium by Nguyen-Ngoc, Kim-Vy, Cheung, Kevin J, Brenot, Audrey, Shamir, Eliah R, Gray, Ryan S, Hines, William C, Yaswen, Paul, Werb, Zena, Ewald, Andrew J

“…Breast cancer progression involves genetic changes and changes in the extracellular matrix (ECM). To test the importance of the ECM in tumor cell…”
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The Reissner Fiber Is Highly Dynamic In Vivo and Controls Morphogenesis of the Spine by Troutwine, Benjamin R., Gontarz, Paul, Konjikusic, Mia J., Minowa, Ryoko, Monstad-Rios, Adrian, Sepich, Diane S., Kwon, Ronald Y., Solnica-Krezel, Lilianna, Gray, Ryan S.

“…Cerebrospinal fluid (CSF) physiology is important for the development and homeostasis of the central nervous system, and its disruption has been linked to…”
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A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis by Chen, Qian, Zhang, Nailing, Gray, Ryan S, Li, Huili, Ewald, Andrew J, Zahnow, Cynthia A, Pan, Duojia

“…Despite recent progress, the physiological role of Hippo signaling in mammary gland development and tumorigenesis remains poorly understood. Here we show that…”
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Zebrafish: An Emerging Model for Orthopedic Research by Busse, Björn, Galloway, Jenna L., Gray, Ryan S., Harris, Matthew P., Kwon, Ronald Y.

“…ABSTRACT Advances in next‐generation sequencing have transformed our ability to identify genetic variants associated with clinical disorders of the…”
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Mutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development by Konjikusic, Mia J, Yeetong, Patra, Boswell, Curtis W, Lee, Chanjae, Roberson, Elle C, Ittiwut, Rungnapa, Suphapeetiporn, Kanya, Ciruna, Brian, Gurnett, Christina A, Wallingford, John B, Shotelersuk, Vorasuk, Gray, Ryan S

“…Cerebrospinal fluid flow is crucial for neurodevelopment and homeostasis of the ventricular system of the brain, with localized flow being established by the…”
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Planar Cell Polarity Acts Through Septins to Control Collective Cell Movement and Ciliogenesis by Kim, Su Kyoung, Shindo, Asako, Park, Tae Joo, Oh, Edwin C, Ghosh, Srimoyee, Gray, Ryan S, Lewis, Richard A, Johnson, Colin A, Attie-Bittach, Tania, Katsanis, Nicholas, Wallingford, John B

“…The planar cell polarity (PCP) signaling pathway governs collective cell movements during vertebrate embryogenesis, and certain PCP proteins are also…”
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A missense variant in SLC39A8 is associated with severe idiopathic scoliosis by Haller, Gabe, McCall, Kevin, Jenkitkasemwong, Supak, Sadler, Brooke, Antunes, Lilian, Nikolov, Momchil, Whittle, Julia, Upshaw, Zachary, Shin, Jimann, Baschal, Erin, Cruchaga, Carlos, Harms, Matthew, Raggio, Cathleen, Morcuende, Jose A., Giampietro, Philip, Miller, Nancy H., Wise, Carol, Gray, Ryan S., Solnica-Krezel, Lila, Knutson, Mitchell, Dobbs, Matthew B., Gurnett, Christina A.

“…Genetic factors predictive of severe adolescent idiopathic scoliosis (AIS) are largely unknown. To identify genetic variation associated with severe AIS, we…”
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Motor protein Kif6 regulates cilia motility and polarity in brain ependymal cells by Takagishi, Maki, Yue, Yang, Gray, Ryan S, Verhey, Kristen J, Wallingford, John B

“…Motile cilia on ependymal cells that line brain ventricular walls beat in concert to generate a flow of laminar cerebrospinal fluid (CSF). Dyneins and kinesins…”
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Genomic characterization of the adolescent idiopathic scoliosis-associated transcriptome and regulome by Makki, Nadja, Zhao, Jingjing, Liu, Zhaoyang, Eckalbar, Walter L, Ushiki, Aki, Khanshour, Anas M, Wu, Joe, Rios, Jonathan, Gray, Ryan S, Wise, Carol A, Ahituv, Nadav

“…Abstract Adolescent idiopathic scoliosis (AIS), a sideways curvature of the spine, is the most common pediatric musculoskeletal disorder, affecting ~3% of the…”
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Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations by Gray, Ryan S., Wilm, Thomas P., Smith, Jeff, Bagnat, Michel, Dale, Rodney M., Topczewski, Jacek, Johnson, Stephen L., Solnica-Krezel, Lilianna

“…Congenital vertebral malformations (CVM) occur in 1 in 1000 live births and in many cases can cause spinal deformities, such as scoliosis, and result in…”
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Regulation of terminal hypertrophic chondrocyte differentiation in Prmt5 mutant mice modeling infantile idiopathic scoliosis by Liu, Zhaoyang, Ramachandran, Janani, Vokes, Steven A, Gray, Ryan S

“…Idiopathic scoliosis (IS) is the most common type of musculoskeletal defect affecting children worldwide, and is classified by age of onset, location and…”
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Kinesin family member 6 (kif6) is necessary for spine development in zebrafish by Buchan, Jillian G., Gray, Ryan S., Gansner, John M., Alvarado, David M., Burgert, Lydia, Gitlin, Jonathan D., Gurnett, Christina A., Goldsmith, Matthew I.

“…Background: Idiopathic scoliosis is a form of spinal deformity that affects 2–3% of children and results in curvature of the spine without structural defects…”
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Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice by Liu, Zhaoyang, Easson, Garrett W D, Zhao, Jingjing, Makki, Nadja, Ahituv, Nadav, Hilton, Matthew J, Tang, Simon Y, Gray, Ryan S

“…Degenerative changes of the intervertebral disc (IVD) are a leading cause of disability affecting humans worldwide and has been attributed primarily to trauma…”
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A comparative study of the turnover of multiciliated cells in the mouse trachea, oviduct, and brain by Roberson, Elle C., Tran, Ngan K., Konjikusic, Mia J., Fitch, Rebecca D., Gray, Ryan S., Wallingford, John B.

“…Background In mammals, multiciliated cells (MCCs) line the lumen of the trachea, oviduct, and brain ventricles, where they drive fluid flow across the…”
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The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development by Wallingford, John B, Finnell, Richard H, Gray, Ryan S, Abitua, Philip B, Wlodarczyk, Bogdan J, Szabo-Rogers, Heather L, Blanchard, Otis, Lee, Insuk, Weiss, Greg S, Liu, Karen J, Marcotte, Edward M

“…The planar cell polarity (PCP) signalling pathway is essential for embryonic development because it governs diverse cellular behaviours, and 'core PCP'…”
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An adhesion G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignment by Liu, Zhaoyang, Hussien, Amro A, Wang, Yunjia, Heckmann, Terry, Gonzalez, Roberto, Karner, Courtney M, Snedeker, Jess G, Gray, Ryan S

“…Adolescent idiopathic scoliosis (AIS) is the most common spine disorder affecting children worldwide, yet little is known about the pathogenesis of this…”
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The Reissner fiber under tension in vivo shows dynamic interaction with ciliated cells contacting the cerebrospinal fluid by Bellegarda, Celine, Zavard, Guillaume, Moisan, Lionel, Brochard-Wyart, Françoise, Joanny, Jean-François, Gray, Ryan S, Cantaut-Belarif, Yasmine, Wyart, Claire

“…The Reissner fiber (RF) is an acellular thread positioned in the midline of the central canal that aggregates thanks to the beating of numerous cilia from…”
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Cellular mechanisms regulating epithelial morphogenesis and cancer invasion by Gray, Ryan S, Cheung, Kevin J, Ewald, Andrew J

“…The cellular mechanisms driving mammalian epithelial morphogenesis are of significant fundamental and practical interest. Historically, these processes have…”
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Biomechanical interplay between anisotropic re-organization of cells and the surrounding matrix underlies transition to invasive cancer spread by Kim, Deok-Ho, Ewald, Andrew J., Park, JinSeok, Kshitiz, Kwak, Moonkyu, Gray, Ryan S., Su, Chia-Yi, Seo, Jayhyun, An, Steven S., Levchenko, Andre

“…The root cause of cancer mortality and morbidity is the metastatic spread of the primary tumor, but underlying mechanisms remain elusive. Here we investigate…”
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