Search Results - "Gray, Norman M"

Effect of Detergent on “Promiscuous” Inhibitors by Ryan, Ali J, Gray, Norman M, Lowe, Peter N, Chung, Chun-wa

“…The term “promiscuous” inhibitors has been coined for compounds whose inhibition mechanism involves the interaction of aggregates of many compound molecules…”
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The role of the cylooxygenase pathway in nociception and pain by Bingham, Sharon, Beswick, Paul J., Blum, David E., Gray, Norman M., Chessell, Iain P.

“…Cycloxygenase (COX) pathways have long been targeted for the treatment of inflammatory pain, initially through the use of NSAIDs. With the demonstration of two…”
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Development of Cell-Based Assays for In Vitro Characterization of Hepatitis C Virus NS3/4A Protease Inhibitors by Chung, Victoria, Carroll, Anthony R, Gray, Norman M, Parry, Nigel R, Thommes, Pia A, Viner, K Claire, D'Souza, Eric A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Pyrrolidine-5,5-trans-lactams. 1. Synthesis and Incorporation into Inhibitors of Hepatitis C Virus NS3/4A Protease by Andrews, David M, Carey, Seb J, Chaignot, Helene, Coomber, Barry A, Gray, Norman M, Hind, S. Lucy, Jones, Paul S, Mills, Gail, Robinson, J. Ed, Slater, Martin J

“…In this, the first of two letters, we outline the use of the pyrrolidine-5,5-trans-lactam template to design small, neutral, mechanism-based inhibitors of…”
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A series of penicillin-derived C2-symmetric inhibitors of HIV-1 proteinase: synthesis, mode of interaction, and structure-activity relationships by Humber, David C, Bamford, Mark J, Bethell, Richard C, Cammack, Nicholas, Cobley, Kevin, Evans, Derek N, Gray, Norman M, Hann, Michael M, Orr, David C

“…The C2-symmetric diester 1 was identified by random screening as a novel inhibitor of HIV-1 proteinase. This led to the preparation of a series of related more…”
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Large scale expression and purification of recombinant HIV-1 proteinase from Escherichia coli by Singh, O M, Baines, D S, Hall, R M, Gray, N M, Weir, M P

“…The availability of target proteins in sufficient quantity is a limiting factor in crystallographic studies and therefore in rational drug design. Even after…”
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Development of cell-based assays for in vitro characterization of gepatitis C Virus NS3/4A Protease Inhibitors by CHUNG, Victoria, CARROLL, Anthony R, GRAY, Norman M, PARRY, Nigel R, THOMMES, Pia A, VINER, K. Claire, D'SOUZA, Eric A

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The intracellular phosphorylation of (−)-2′-deoxy-3′-thiacytidine (3TC) and the incorporation of 3TC 5′-monophosphate into DNA by HIV-1 reverse transcriptase and human DNA polymerase γ by Gray, Norman M., Marr, Clara L.P., Penn, Charles R., Cameron, Janet M., Bethell, Richard C.

“…(−)-2′-deoxy-3′-thiacytidine (3TC) † † 3TC is a trademark of Glaxo Group Ltd., Glaxo House, Greenford Road, Greenford, Middlesex UB6 OHE, U.K. has been shown…”
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Assist Devices Fail to Reverse Patterns of Fetal Gene Expression Despite β-Blockers by Lowes, Brian D., MD, Zolty, Ronald, MD, Shakar, Simon F., MD, Brieke, Andreas, MD, Gray, Norman, MD, Reed, Michael, MD, Calalb, Mihail, MD, Minobe, Wayne, Lindenfeld, JoAnn, MD, Wolfel, Eugene E., MD, Geraci, Mark, MD, Bristow, Michael R., MD, PhD, Cleveland, Joseph, MD

“…Background Heart failure is associated with reversal to a fetal gene expression pattern of contractile and metabolic genes. Substantial recovery of ventricular…”
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Discovery and analysis of a series of C2-symmetric HIV-1 proteinase inhibitors derived from penicillin by Gray, N M, Cameron, J M, Cammack, N, Cobley, K N, Holmes, D S, Humber, D C, Orr, D C, Penn, C R, Potter, R, Madar, S

“…In order to identify a suitable peptide substrate for human immunodeficiency virus-1 (HIV-1) proteinase, a range of peptides from various cleavage sites within…”
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