Search Results - "Gray, Nicola K."

The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover by Brook, Matthew, Gray, Nicola K

“…The function of cytoplasmic PABPs [poly(A)-binding proteins] in promoting mRNA translation has been intensively studied. However, PABPs also have less clearly…”
Get more information

Poly(A)-binding proteins are required for diverse biological processes in metazoans by Smith, Richard W P, Blee, Tajekesa K P, Gray, Nicola K

“…PABPs [poly(A)-binding proteins] bind to the poly(A) tail of eukaryotic mRNAs and are conserved in species ranging from yeast to human. The prototypical…”
Get more information

Poly(A)-binding proteins and mRNA localization: who rules the roost? by Gray, Nicola K, Hrabálková, Lenka, Scanlon, Jessica P, Smith, Richard W P

“…RNA-binding proteins are often multifunctional, interact with a variety of protein partners and display complex localizations within cells. Mammalian…”
Get more information

SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout by Wright, Alan F, Vitart, Veronique, Rudan, Igor, Hayward, Caroline, Gray, Nicola K, Floyd, James, Palmer, Colin NA, Knott, Sara A, Kolcic, Ivana, Polasek, Ozren, Graessler, Juergen, Wilson, James F, Marinaki, Anthony, Riches, Philip L, Shu, Xinhua, Janicijevic, Branka, Smolej-Narancic, Nina, Gorgoni, Barbara, Morgan, Joanne, Campbell, Susan, Biloglav, Zrinka, Barac-Lauc, Lovorka, Pericic, Marijana, Klaric, Irena Martinovic, Zgaga, Lina, Skaric-Juric, Tatjana, Wild, Sarah H, Richardson, William A, Hohenstein, Peter, Kimber, Charley H, Tenesa, Albert, Donnelly, Louise A, Fairbanks, Lynette D, Aringer, Martin, McKeigue, Paul M, Ralston, Stuart H, Morris, Andrew D, Rudan, Pavao, Hastie, Nicholas D, Campbell, Harry

“…Uric acid is the end product of purine metabolism in humans and great apes, which have lost hepatic uricase activity, leading to uniquely high serum uric acid…”
Get full text

Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation by Brook, Matthew, Tomlinson, Gareth H., Miles, Katherine, Smith, Richard W. P., Rossi, Adriano G., Hiemstra, Pieter S., van ’t Wout, Emily F. A., Dean, Jonathan L. E., Gray, Nicola K., Lu, Wuyuan, Gray, Mohini

“…Neutrophils are the first and most numerous cells to arrive at the site of an inflammatory insult and are among the first to die. We previously reported that…”
Get full text

Viral and cellular mRNA-specific activators harness PABP and eIF4G to promote translation initiation downstream of cap binding by Smith, Richard W. P., Anderson, Ross C., Larralde, Osmany, Smith, Joel W. S., Gorgoni, Barbara, Richardson, William A., Malik, Poonam, Graham, Sheila V., Gray, Nicola K.

“…Regulation of mRNA translation is a major control point for gene expression and is critical for life. Of central importance is the complex between cap-bound…”
Get full text

mRNA-specific regulation of translation by poly(A)-binding proteins by Burgess, Hannah M, Gray, Nicola K

“…The regulation of translation has emerged as a major determinant of gene expression and is critical for both normal cellular function and the development of…”
Get more information

Poly(A)-binding protein (PABP): a common viral target by Smith, Richard W P, Gray, Nicola K

“…Cytoplasmic PABP [poly(A)-binding protein] is a multifunctional protein with well-studied roles in mRNA translation and stability. In the present review, we…”
Get more information

The DAZL and PABP families: RNA-binding proteins with interrelated roles in translational control in oocytes by Brook, Matthew, Smith, Joel W S, Gray, Nicola K

“…Gametogenesis is a highly complex process that requires the exquisite temporal, spatial and amplitudinal regulation of gene expression at multiple levels…”
Get full text

Modulation of the cytoplasmic functions of mammalian post-transcriptional regulatory proteins by methylation and acetylation: a key layer of regulation waiting to be uncovered? by Blee, Tajekesa K P, Gray, Nicola K, Brook, Matthew

“…Post-transcriptional control of gene expression is critical for normal cellular function and viability and many of the proteins that mediate…”
Get more information

Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPs by Burgess, Hannah M, Richardson, William A, Anderson, Ross C, Salaun, Christine, Graham, Sheila V, Gray, Nicola K

“…Poly(A)-binding protein 1 (PABP1) has a fundamental role in the regulation of mRNA translation and stability, both of which are crucial for a wide variety of…”
Get full text

A novel role for shuttling SR proteins in mRNA translation by Sanford, Jeremy R, Gray, Nicola K, Beckmann, Karsten, Cáceres, Javier F

“…The Ser-Arg-rich (SR) proteins comprise a large family of nuclear phosphoproteins that are required for constitutive and alternative splicing. A subset of SR…”
Get full text

Regulation of mRNA translation by 5′- and 3′-UTR-binding factors by Wilkie, Gavin S., Dickson, Kirsten S., Gray, Nicola K.

“…The translational regulation of specific mRNAs is important for controlling gene expression. The past few years have seen a rapid expansion in the…”
Get full text

FMRP Associates with Cytoplasmic Granules at the Onset of Meiosis in the Human Oocyte by Rosario, Roseanne, Filis, Panagiotis, Tessyman, Victoria, Kinnell, Hazel, Childs, Andrew J, Gray, Nicola K, Anderson, Richard A

“…Germ cell development and primordial follicle formation during fetal life is critical in establishing the pool of oocytes that subsequently determines the…”
Get full text

Translation of the synaptonemal complex component Sycp3 is enhanced in vivo by the germ cell specific regulator Dazl by Reynolds, Nicola, Collier, Brian, Bingham, Victoria, Gray, Nicola K, Cooke, Howard J

“…DAZ-related genes are essential for gametogenesis in diverse metazoa: in human males, a loss of DAZ genes is associated with infertility. These genes,…”
Get full text

The multifunctional poly(A)-binding protein (PABP) 1 is subject to extensive dynamic post-translational modification, which molecular modelling suggests plays an important role in co-ordinating its activities by Brook, Matthew, McCracken, Lora, Reddington, James P, Lu, Zhi-Liang, Morrice, Nicholas A, Gray, Nicola K

“…PABP1 [poly(A)-binding protein 1] is a central regulator of mRNA translation and stability and is required for miRNA (microRNA)-mediated regulation and…”
Get more information

Embryonic poly(A)-binding protein (ePAB) phosphorylation is required for Xenopus oocyte maturation by Friend, Kyle, Brook, Matthew, Bezirci, F Betül, Sheets, Michael D, Gray, Nicola K, Seli, Emre

“…Oocyte maturation and early embryonic development require the cytoplasmic polyadenylation and concomitant translational activation of stored maternal mRNAs…”
Get more information

Dazl binds in vivo to specific transcripts and can regulate the pre-meiotic translation of Mvh in germ cells by Reynolds, Nicola, Collier, Brian, Maratou, Klio, Bingham, Victoria, Speed, Robert M., Taggart, Mary, Semple, Colin A., Gray, Nicola K., Cooke, Howard J.

“…Gametogenesis is a complex process subject to strict controls at both levels of transcription and translation. Members of a family of conserved RNA-binding…”
Get full text

CONTROL OF TRANSLATION INITIATION IN ANIMALS by Gray, Nicola K, Wickens, Marvin

“…Regulation of translation initiation is a central control point in animal cells. We review our current understanding of the mechanisms of regulation, drawing…”
Get full text

Deletion of the pluripotency-associated Tex19.1 gene causes activation of endogenous retroviruses and defective spermatogenesis in mice by Ollinger, Rupert, Childs, Andrew J, Burgess, Hannah M, Speed, Robert M, Lundegaard, Pia R, Reynolds, Nicola, Gray, Nicola K, Cooke, Howard J, Adams, Ian R

“…As genetic information is transmitted through successive generations, it passes between pluripotent cells in the early embryo and germ cells in the developing…”
Get full text