Search Results - "Gray, Lawrence R"

Regulation of pyruvate metabolism and human disease by Gray, Lawrence R., Tompkins, Sean C., Taylor, Eric B.

“…Pyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human metabolism. Pyruvate is the end-product of glycolysis, is derived from…”
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Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis by Gray, Lawrence R., Sultana, Mst Rasheda, Rauckhorst, Adam J., Oonthonpan, Lalita, Tompkins, Sean C., Sharma, Arpit, Fu, Xiaorong, Miao, Ren, Pewa, Alvin D., Brown, Kathryn S., Lane, Erin E., Dohlman, Ashley, Zepeda-Orozco, Diana, Xie, Jianxin, Rutter, Jared, Norris, Andrew W., Cox, James E., Burgess, Shawn C., Potthoff, Matthew J., Taylor, Eric B.

“…Gluconeogenesis is critical for maintenance of euglycemia during fasting. Elevated gluconeogenesis during type 2 diabetes (T2D) contributes to chronic…”
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Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis by Tompkins, Sean C., Sheldon, Ryan D., Rauckhorst, Adam J., Noterman, Maria F., Solst, Shane R., Buchanan, Jane L., Mapuskar, Kranti A., Pewa, Alvin D., Gray, Lawrence R., Oonthonpan, Lalita, Sharma, Arpit, Scerbo, Diego A., Dupuy, Adam J., Spitz, Douglas R., Taylor, Eric B.

“…Hepatocellular carcinoma (HCC) is a devastating cancer increasingly caused by non-alcoholic fatty liver disease (NAFLD). Disrupting the liver Mitochondrial…”
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Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness by Sharma, Arpit, Oonthonpan, Lalita, Sheldon, Ryan D, Rauckhorst, Adam J, Zhu, Zhiyong, Tompkins, Sean C, Cho, Kevin, Grzesik, Wojciech J, Gray, Lawrence R, Scerbo, Diego A, Pewa, Alvin D, Cushing, Emily M, Dyle, Michael C, Cox, James E, Adams, Chris, Davies, Brandon S, Shields, Richard K, Norris, Andrew W, Patti, Gary, Zingman, Leonid V, Taylor, Eric B

“…Metabolic cycles are a fundamental element of cellular and organismal function. Among the most critical in higher organisms is the Cori Cycle, the systemic…”
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The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity by Rauckhorst, Adam J., Gray, Lawrence R., Sheldon, Ryan D., Fu, Xiaorong, Pewa, Alvin D., Feddersen, Charlotte R., Dupuy, Adam J., Gibson-Corley, Katherine N., Cox, James E., Burgess, Shawn C., Taylor, Eric B.

“…Excessive hepatic gluconeogenesis is a defining feature of type 2 diabetes (T2D). Most gluconeogenic flux is routed through mitochondria. The mitochondrial…”
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A Method for Multiplexed Measurement of Mitochondrial Pyruvate Carrier Activity by Gray, Lawrence R., Rauckhorst, Adam J., Taylor, Eric B.

“…The discovery that the MPC1 and MPC2 genes encode the protein components of the mitochondrial pyruvate carrier (MPC) has invigorated studies of mitochondrial…”
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Mitochondrial pyruvate carriers are required for myocardial stress adaptation by Zhang, Yuan, Taufalele, Paul V., Cochran, Jesse D., Robillard-Frayne, Isabelle, Marx, Jonas Maximilian, Soto, Jamie, Rauckhorst, Adam J., Tayyari, Fariba, Pewa, Alvin D., Gray, Lawrence R., Teesch, Lynn M., Puchalska, Patrycja, Funari, Trevor R., McGlauflin, Rose, Zimmerman, Kathy, Kutschke, William J., Cassier, Thomas, Hitchcock, Shannon, Lin, Kevin, Kato, Kevin M., Stueve, Jennifer L., Haff, Lauren, Weiss, Robert M., Cox, James E., Rutter, Jared, Taylor, Eric B., Crawford, Peter A., Lewandowski, E. Douglas, Des Rosiers, Christine, Abel, E. Dale

“…In addition to fatty acids, glucose and lactate are important myocardial substrates under physiologic and stress conditions. They are metabolized to pyruvate,…”
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Two human patient mitochondrial pyruvate carrier mutations reveal distinct molecular mechanisms of dysfunction by Oonthonpan, Lalita, Rauckhorst, Adam J, Gray, Lawrence R, Boutron, Audrey C, Taylor, Eric B

“…The Mitochondrial Pyruvate Carrier (MPC) occupies a central metabolic node by transporting cytosolic pyruvate into the mitochondrial matrix and linking…”
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Transport Kinetics and Selectivity of HpUreI, the Urea Channel from Helicobacter pylori by Gray, Lawrence R, Gu, Sean X, Quick, Matthias, Khademi, Shahram

“…Helicobacter pylori’s unique ability to colonize and survive in the acidic environment of the stomach is critically dependent on uptake of urea through the…”
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Publisher Correction: Mitochondrial pyruvate carriers are required for myocardial stress adaptation by Zhang, Yuan, Taufalele, Paul V., Cochran, Jesse D., Robillard-Frayne, Isabelle, Marx, Jonas Maximilian, Soto, Jamie, Rauckhorst, Adam J., Tayyari, Fariba, Pewa, Alvin D., Gray, Lawrence R., Teesch, Lynn M., Puchalska, Patrycja, Funari, Trevor R., McGlauflin, Rose, Zimmerman, Kathy, Kutschke, William J., Cassier, Thomas, Hitchcock, Shannon, Lin, Kevin, Kato, Kevin M., Stueve, Jennifer L., Haff, Lauren, Weiss, Robert M., Cox, James E., Rutter, Jared, Taylor, Eric B., Crawford, Peter A., Lewandowski, E. Douglas, Des Rosiers, Christine, Abel, E. Dale

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Transport Kinetics and Selectivity of Hp UreI, the Urea Channel from Helicobacter pylori by Gray, Lawrence R., Gu, Sean X., Quick, Matthias, Khademi, Shahram

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Solute Specificity and Transport Kinetics of the Urea Channel from Helicobacter Pylori by Gray, Lawrence R., Gu, Sean, Khademi, Shahram

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