Search Results - "Gray, L E"

Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat by GRAY, L. Earl, OSTBY, Joseph, FURR, Johnathan, PRICE, Matthew, RAO VEERAMACHANENI, D. N, PARKS, Louise

“…In mammals, exposure to antiandrogenic chemicals during sexual differentiation can produce malformations of the reproductive tract. Perinatal administration of…”
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Effects of environmental antiandrogens on reproductive development in experimental animals by Gray, L. E., Ostby, J., Furr, J., Wolf, C. J., Lambright, C., Parks, L., Veeramachaneni, D. N., Wilson, V., Price, M., Hotchkiss, A., Orlando, E., Guillette, L.

“…Chemicals that act as androgen receptor (AR) agonists and antagonists or inhibit fetal steroidogenesis can induce reproductive malformations in humans and…”
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A Novel Cell Line, MDA-kb2, That Stably Expresses an Androgen- and Glucocorticoid-Responsive Reporter for the Detection of Hormone Receptor Agonists and Antagonists by Wilson, Vickie S., Bobseine, Kathy, Lambright, Christy R., Gray, L. E.

“…The U.S. Environmental Protection Agency has proposed that in vitro assays for estrogen receptor (ER)- and androgen receptor (AR)-mediated actions be included…”
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Masculinization of Female Mosquitofish in Kraft Mill Effluent-Contaminated Fenholloway River Water Is Associated with Androgen Receptor Agonist Activity by Parks, L. G., Lambright, C. S., Orlando, E. F., Guillette, L. J., Ankley, G. T., Gray, L. E.

“…Female mosquitofish (Gambusia affinis holbrooki) downstream from Kraft paper mills in Florida display masculinization of the anal fin, an androgen-dependent…”
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In vivo and in vitro anti-androgenic effects of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture by Stoker, T.E., Cooper, R.L., Lambright, C.S., Wilson, V.S., Furr, J., Gray, L.E.

“…PBDEs have been synthesized in large quantities as flame retardants for commercial products, such as electronic equipment and textiles. The rising in levels of…”
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Metabolite Profiling and a Transcriptional Activation Assay Provide Direct Evidence of Androgen Receptor Antagonism by Bisphenol A in Fish by Ekman, D. R, Hartig, P. C, Cardon, M, Skelton, D. M, Teng, Q, Durhan, E. J, Jensen, K. M, Kahl, M. D, Villeneuve, D. L, Gray, L. E, Collette, T. W, Ankley, G. T

“…Widespread environmental contamination by bisphenol A (BPA) has created the need to fully define its potential toxic mechanisms of action (MOA) to properly…”
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Baseline abnormal liver function tests are more important than age in the development of isoniazid-induced hepatoxicity for patients receiving preventive therapy for latent tuberculosis infection by Gray, E. L., Goldberg, H. F.

“…Background One of the cornerstones of Australia's public health programmes to eliminate tuberculosis (TB) is the identification and treatment of latent…”
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Cumulative effects of in utero administration of mixtures of reproductive toxicants that disrupt common target tissues via diverse mechanisms of toxicity by Rider, C. V., Furr, J. R., Wilson, V. S., Gray Jr, L. E.

“…Summary Although risk assessments are typically conducted on a chemical‐by‐chemical basis, the 1996 Food Quality Protection Act required the US Environmental…”
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The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat by PARKS, Louise G, OSTBY, Joe S, LAMBRIGHT, Christy R, ABBOTT, Barbara D, KLINEFELTER, Gary R, BARLOW, Norman J, GRAY, L. Earl

“…Phthalate esters (PE) such as DEHP are high production volume plasticizers used in vinyl floors, food wraps, cosmetics, medical products, and toys. In spite of…”
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Cellular and molecular mechanisms of action of linuron: An antiandrogenic herbicide that produces reproductive malformations in male rats by LAMBRIGHT, C, OSTBY, J, BOBSEINE, K, WILSON, V, HOTCHKISS, A. K, MANN, P. C, GRAY, L. E

“…Antiandrogenic chemicals alter sex differentiation by several different mechanisms. Some, like flutamide, procymidone, or vinclozolin compete with androgens…”
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A mixture of the antiandrogens linuron and butyl benzyl phthalate alters sexual differentiation of the male rat in a cumulative fashion by HOTCHKISS, A. K, PARKS-SALDUTTI, L. G, OSTBY, J. S, LAMBRIGHT, C, FURR, J, VANDENBERGH, J. G, GRAY, L. E

“…Prenatal exposure to environmental chemicals that interfere with the androgen signaling pathway can cause permanent adverse effects on reproductive development…”
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In utero exposure to the environmental androgen trenbolone masculinizes female Sprague–Dawley rats by Hotchkiss, A.K., Furr, J., Makynen, E.A., Ankley, G.T., Gray, L.E.

“…Recently, the occurrence of environmental contaminants with androgenic activity has been described from pulp and paper mill effluents and beef feedlot…”
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In utero exposure to an AR antagonist plus an inhibitor of fetal testosterone synthesis induces cumulative effects on F1 male rats by Hotchkiss, A.K., Rider, C.V., Furr, J., Howdeshell, K.L., Blystone, C.R., Wilson, V.S., Gray Jr, L.E.

“…Risk assessments are typically conducted on a chemical-by-chemical basis; however, many regulatory bodies are developing frameworks for assessing the…”
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A Dose–Response Analysis of the Reproductive Effects of a Single Gestational Dose of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Male Long Evans Hooded Rat Offspring by Gray, L.E., Ostby, J.S., Kelce, W.R.

“…Male rats exposedin uteroto 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) display reduced fertility as a consequence of the direct action of TCDD on the…”
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An environmental antiandrogen, vinclozolin, alters the organization of play behavior by Hotchkiss, A.K., Ostby, J.S., Vandenbergh, J.G., Gray, L.E.

“…During mammalian sexual differentiation, the androgens, testosterone and dihydrotestosterone are critical for the organization of the male phenotype. In rats,…”
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Androgens and Environmental Antiandrogens Affect Reproductive Development and Play Behavior in the Sprague-Dawley Rat by Hotchkiss, A. K., Ostby, J. S., Vandenbergh, J. G., Gray, L. E.

“…In mammals, exposure to androgens early in development is essential for masculinization of the male reproductive phenotype. Male fetuses exposed to…”
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Development of Two Androgen Receptor Assays Using Adenoviral Transduction of MMTV-Luc Reporter and/or hAR for Endocrine Screening by Hartig, P. C., Bobseine, K. L., Britt, B. H., Cardon, M. C., Lambright, C. R., Wilson, V. S., Gray, L. E.

“…The discovery of xenobiotics that interfere with androgen activity has highlighted the need to assess chemicals for their ability to modulate…”
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Characterization of the Period of Sensitivity of Fetal Male Sexual Development to Vinclozolin by Wolf, Cynthia J., LeBlanc, Gerald A., Ostby, Joseph S., Gray, L. Earl

“…Vinclozolin is a fungicide whose metabolites are androgen receptor (AR) antagonists. Previous work in our laboratory showed that perinatal administration of…”
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In Vitro and in Vivo Effects of 17β-Trenbolone: A Feedlot Effluent Contaminant by Wilson, Vickie S., Lambright, Christy, Ostby, Joe, Gray, L. E.

“…Concern has arisen regarding the presence and persistence of trenbolone in the environment. Trenbolone acetate is an anabolic steroid used to promote growth in…”
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High throughput adjustable 96-well plate assay for androgen receptor binding: A practical approach for EDC screening using the chimpanzee AR by Hartig, P.C., Cardon, M.C., Blystone, C.R., Gray, L.E., Wilson, V.S.

“…The issue as to whether natural and man-made chemicals interfere with endocrine function has raised concerns. This interference could be biologically…”
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