Search Results - "Gray, Jake A"

BAFF neutralization impairs the autoantibody-mediated clearance of dead adipocytes and aggravates obesity-induced insulin resistance by Lempicki, Melissa D, Gray, Jake A, Abuna, Gabriel, Murata, Ramiro M, Divanovic, Senad, McNamara, Coleen A, Meher, Akshaya K

“…B cell-activating factor (BAFF) is a critical TNF-family cytokine that regulates homeostasis and peripheral tolerance of B2 cells. BAFF overproduction promotes…”
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BAFF 60‐mer binding to BAFF receptor 3 utilizes the NF‐κB1 signaling pathway to hyperactivate B cells by Lempicki, Melissa D., Serbulea, Vlad, Paul, Saikat, Upchurch, Clint M., Sahu, Srabani, Gray, Jake A., Ailawadi, Gorav, Garcia, Brandon L., McNamara, Coleen, Leitinger, Norbert, Meher, Akshaya K.

“…B cell activating factor (BAFF) is a critical cytokine for survival, differentiation, proliferation, and antibody production of B cells. Abnormal B cell…”
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BAFF antagonism via the BAFF receptor 3 binding site attenuates BAFF 60-mer-induced classical NF-κB signaling and metabolic reprogramming of B cells by D. Lempicki, Melissa, Paul, Saikat, Serbulea, Vlad, Upchurch, Clint M., Sahu, Srabani, Gray, Jake A., Ailawadi, Gorav, Garcia, Brandon L., McNamara, Coleen A., Leitinger, Norbert, Meher, Akshaya K.

“…•BAFF 3-mer, BAFF 60-mer, and higher order multimers are present in human plasma.•Compared to the BAFF 3-mer, BAFF 60-mer strongly induces the transcriptome of…”
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