Search Results - "Gray, JR"

Hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) alters maternal and fetal glucose and lipid metabolism and produces neonatal mortality, low birthweight, and hepatomegaly in the Sprague-Dawley rat by Conley, Justin M., Lambright, Christy S., Evans, Nicola, McCord, James, Strynar, Mark J., Hill, Donna, Medlock-Kakaley, Elizabeth, Wilson, Vickie S., Gray, L. Earl

“…[Display omitted] •HFPO-DA (or GenX) is a developmental toxicant in the rat.•Dysregulation of carbohydrate and lipid metabolism are critical key events.•PPAR…”
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Cumulative maternal and neonatal effects of combined exposure to a mixture of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) during pregnancy in the Sprague-Dawley rat by Conley, Justin M., Lambright, Christy S., Evans, Nicola, Medlock-Kakaley, Elizabeth, Dixon, Aaron, Hill, Donna, McCord, James, Strynar, Mark J., Ford, Jermaine, Gray, L. Earl

“…Globally, biomonitoring data demonstrate virtually all humans carry residues of multiple per- and polyfluoroalkyl substances (PFAS). Despite pervasive…”
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Rebooting nuclear medicine specialist education under the COVID‐19 pandemic: From plenary lectures to active e‐learning by Tulipan, Andreas, Gulati, Ankush, Haslerud, Torjan, Gray, Robert, Biermann, Martin

“…Despite major reforms of specialist training in the Nordic countries towards concrete learning outcomes and promoting active learning, most specialist courses…”
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A mixture of 15 phthalates and pesticides below individual chemical no observed adverse effect levels (NOAELs) produces reproductive tract malformations in the male rat by Conley, Justin M., Lambright, Christy S., Evans, Nicola, Cardon, Mary, Medlock-Kakaley, Elizabeth, Wilson, Vickie S., Gray, L. Earl

“…•Multiple molecular initiating events lead to adverse male reproductive development.•Rat dams exposed to mixture of 9 phthalates, 5 pesticides, and 1 pesticide…”
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Long-chain perfluoroalkylether carboxylic acids PFO5DoA and PFO4DA alter glucose, bile acid, and thyroid hormone homeostasis in fetal rats from 5-day maternal oral exposure by Conley, Justin M., Lambright, Christy S., Evans, Nicola, Bangma, Jacqueline, Ford, Jermaine, Hill, Donna, Gray, L. Earl

“…Chemical monitoring studies in North Carolina, USA and Shandong, China have reported detections of perfluoroalkylether carboxylic acids of increasing chain…”
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Developmental toxicity of Nafion byproduct 2 (NBP2) in the Sprague-Dawley rat with comparisons to hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) and perfluorooctane sulfonate (PFOS) by Conley, Justin M., Lambright, Christy S., Evans, Nicola, Medlock-Kakaley, Elizabeth, Hill, Donna, McCord, James, Strynar, Mark J., Wehmas, Leah C., Hester, Susan, MacMillan, Denise K., Gray, L. Earl

“…[Display omitted] Nafion byproduct 2 (NBP2) is a polyfluoroalkyl ether sulfonic acid that was recently detected in surface water, drinking water, and human…”
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Dose additive maternal and offspring effects of oral maternal exposure to a mixture of three PFAS (HFPO-DA, NBP2, PFOS) during pregnancy in the Sprague-Dawley rat by Conley, Justin M., Lambright, Christy S., Evans, Nicola, Farraj, Aimen K., Smoot, Jacob, Grindstaff, Rachel D., Hill, Donna, McCord, James, Medlock-Kakaley, Elizabeth, Dixon, Aaron, Hines, Erin, Gray, L. Earl

“…Simultaneous exposure to multiple per- and polyfluoroalkyl substances (PFAS) is common in humans across the globe. Individual PFAS are associated with adverse…”
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Exploring maternal and developmental toxicity of perfluoroalkyl ether acids PFO4DA and PFO5DoA using hepatic transcriptomics and serum metabolomics by Jackson, Thomas W., Lambright, Christy S., Evans, Nicola, Wehmas, Leah C., MacMillan, Denise K., Bangma, Jacqueline, Gray, L. Earl, Conley, Justin M.

“…Production of per- and polyfluoroalkyl substances (PFAS) has shifted from long-chain perfluoroalkyl acids to short-chain compounds and those with ether bonds…”
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Maternal and Neonatal Effects of Maternal Oral Exposure to Perfluoro-2-methoxyacetic Acid (PFMOAA) during Pregnancy and Early Lactation in the Sprague–Dawley Rat by Conley, Justin M., Lambright, Christy S., Evans, Nicola, Bangma, Jacqueline, Ford, Jermaine, Hill, Donna, Medlock-Kakaley, Elizabeth, Gray, L. Earl

“…Perfluoro-2-methoxyacetic acid (PFMOAA) is a short-chain perfluoroalkyl ether carboxylic acid that has been detected at high concentrations (∼10 μg/L) in…”
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Traceability and Risk Analysis Strategies for Addressing Counterfeit Electronics in Supply Chains for Complex Systems by DiMase, Daniel, Collier, Zachary A., Carlson, Jinae, Gray Jr, Robin B., Linkov, Igor

“…Within the microelectronics industry, there is a growing concern regarding the introduction of counterfeit electronic parts into the supply chain. Even though…”
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De Facto Water Reuse: Bioassay suite approach delivers depth and breadth in endocrine active compound detection by Medlock Kakaley, Elizabeth K., Blackwell, Brett R., Cardon, Mary C., Conley, Justin M., Evans, Nicola, Feifarek, David J., Furlong, Edward T., Glassmeyer, Susan T., Gray, L. Earl, Hartig, Phillip C., Kolpin, Dana W., Mills, Marc A., Rosenblum, Laura, Villeneuve, Daniel L., Wilson, Vickie S.

“…[Display omitted] •A suite of in vitro assays was applied to detect biological activity.•Estrogenic and glucocorticoid activity in effluent was corroborated by…”
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Extracellular Heat Shock Proteins in Cell Signaling and Immunity by CALDERWOOD, STUART K., MAMBULA, SALAMATU S., GRAY JR, PHILLIP J.

“…:  Extracellular stress proteins including heat shock proteins (Hsps) and glucose‐regulated proteins (Grps) are emerging as important mediators of…”
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Targeting the oncogene and kinome chaperone CDC37 by Calderwood, Stuart K, Gray, Phillip J, Prince, Thomas, Cheng, Jinrong, Stevenson, Mary Ann

“…CDC37 is oncogenic because it stabilizes the structures of mutated or overexpressed oncogenic kinases. Targeting this chaperone activity, on which many tumours…”
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In Utero and Lactational Exposure to Bisphenol A, In Contrast to Ethinyl Estradiol, Does Not Alter Sexually Dimorphic Behavior, Puberty, Fertility, and Anatomy of Female LE Rats by Ryan, Bryce C., Hotchkiss, Andrew K., Crofton, Kevin M., Gray, L. Earl

“…Many chemicals released into the environment display estrogenic activity including the oral contraceptive ethinyl estradiol (EE2) and the plastic monomer…”
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Controlled Penetration of a Novel Dimeric Ceramide into and across the Stratum Corneum Using Microemulsions and Various Types of Semisolid Formulations by Neubert, Reinhard H H, Sonnenberger, Stefan, Dobner, Bodo, Gray, Jr, Charles W, Barger, K Natalie, Sevi-Maxwell, Kara, Sommer, Elfi, Wohlrab, Johannes

“…Ceramides (CERs) are integral parts of the intercellular lipid lamellae of the stratum corneum (SC), which is responsible for the barrier function of the skin…”
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Competitive binding comparison of endocrine-disrupting compounds to recombinant androgen receptor from fathead minnow, rainbow trout, and human by Wilson, V.S, Cardon, M.C, Gray, L.E. Jr, Hartig, P.C

“…Typically, in vitro hazard assessments for the identification of endocrine‐disrupting compounds (EDCs), including those outlined in the Endocrine Disruptor…”
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Using targeted fetal rat testis genomic and endocrine alterations to predict the effects of a phthalate mixture on the male reproductive tract by Earl Gray, L., Lambright, Christy S., Evans, Nicola, Ford, Jermaine, Conley, Justin M.

“…[Display omitted] •Phthalate esters disrupt sexual differentiation via a common Adverse Outcome Pathway reducing fetal testosterone levels and altering testis…”
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Endocrine-Disrupting Effects of Cattle Feedlot Effluent on an Aquatic Sentinel Species, the Fathead Minnow by Orlando, Edward F., Kolok, Alan S., Binzcik, Gerry A., Gates, Jennifer L., Horton, Megan K., Lambright, Christy S., Gray, L. Earl, Soto, Ana M., Guillette, Louis J.

“…Over the last decade, research has examined the endocrine-disrupting action of various environmental pollutants, including hormones, pharmaceuticals, and…”
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In utero exposure to simvastatin reduces postnatal survival and permanently alters reproductive tract development in the Crl:CD(SD) male rat by Beverly, Brandiese E.J., Furr, Johnathan R., Lambright, Christy S., Wilson, Vickie S., McIntyre, Barry S., Foster, Paul M.D., Travlos, Greg, Earl Gray, L.

“…We showed previously that in utero exposure to the cholesterol-lowering drug simvastatin (SMV) during sex differentiation lowers fetal lipids and testicular…”
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NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A by Chapin, Robert E., Adams, Jane, Boekelheide, Kim, Gray, L. Earl, Hayward, Simon W., Lees, Peter S.J., McIntyre, Barry S., Portier, Kenneth M., Schnorr, Teresa M., Selevan, Sherry G., Vandenbergh, John G., Woskie, Susan R.

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