Search Results - "Gray, Hillery"
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Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation
Published in eLife (28-05-2019)“…Cancer evolves through a multistep process that occurs by the temporal accumulation of genetic mutations. Tumor-derived exosomes are emerging contributors to…”
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FicD sensitizes cellular response to glucose fluctuations in mouse embryonic fibroblasts
Published in Proceedings of the National Academy of Sciences - PNAS (17-09-2024)“…During homeostasis, the endoplasmic reticulum (ER) maintains productive transmembrane and secretory protein folding that is vital for proper cellular function…”
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Proteomic Profiling of Small Extracellular Vesicles Secreted by Human Pancreatic Cancer Cells Implicated in Cellular Transformation
Published in Scientific reports (07-05-2020)“…Extracellular vesicles secreted from tumor cells are functional vehicles capable of contributing to intercellular communication and metastasis. A growing…”
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FicD regulates adaptation to the unfolded protein response in the murine liver
Published in Biochimie (01-10-2024)“…The unfolded protein response (UPR) is a cellular stress response that is activated when misfolded proteins accumulate in the endoplasmic reticulum (ER)…”
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Fic-mediated AMPylation tempers the unfolded protein response during physiological stress
Published in Proceedings of the National Academy of Sciences - PNAS (09-08-2022)“…The proper balance of synthesis, folding, modification, and degradation of proteins, also known as protein homeostasis, is vital to cellular health and…”
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A calcium channel mutant mouse model of hypokalemic periodic paralysis
Published in The Journal of clinical investigation (01-12-2012)“…Hypokalemic periodic paralysis (HypoPP) is a familial skeletal muscle disorder that presents with recurrent episodes of severe weakness lasting hours to days…”
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A sodium channel knockin mutant (NaV1.4-R669H) mouse model of hypokalemic periodic paralysis
Published in The Journal of clinical investigation (01-10-2011)“…Hypokalemic periodic paralysis (HypoPP) is an ion channelopathy of skeletal muscle characterized by attacks of muscle weakness associated with low serum K+…”
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Role of Two Metacaspases in Development and Pathogenicity of the Rice Blast Fungus Magnaporthe oryzae
Published in mBio (09-02-2021)“…Rice blast disease caused by is a devastating disease of cultivated rice worldwide. Infections by this fungus lead to a significant reduction in rice yields…”
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Systemic IFN-α drives kidney nephritis in B6.Sle123 mice
Published in European journal of immunology (01-07-2008)“…The impact of IFN-α secretion on disease progression was assessed by comparing phenotypic changes in the lupus-prone B6.Sle1Sle2Sle3 (B6.Sle123) strain and the…”
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Abstract 1710 rAMPing up the stress: Investigating the regulation of bifunctional FicD activity
Published in The Journal of biological chemistry (01-03-2024)Get full text
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Abstract 1986 Analyzing the Effects of Repetitive and Chronic Stress in FicD Knock-out Mice
Published in The Journal of biological chemistry (01-03-2024)Get full text
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Abstract 1981 FicD Sensitizes Cellular Response to Glucose Fluctuations in Mouse Embryonic Fibroblasts
Published in The Journal of biological chemistry (01-03-2024)Get full text
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Autoantibody profiling to identify individuals at risk for systemic lupus erythematosus
Published in Journal of autoimmunity (01-11-2006)“…The objective of this study was to determine the prevalence of lupus-related autoimmunity in a community-based cohort of over 3000 subjects, using a…”
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Systemic IFN‐α drives kidney nephritis in B6. Sle123 mice
Published in European journal of immunology (01-07-2008)“…Abstract The impact of IFN‐α secretion on disease progression was assessed by comparing phenotypic changes in the lupus‐prone B6. Sle1Sle2Sle3 (B6. Sle123 )…”
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