Search Results - "Gray, Alasdair"

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY by Harding, Simon D, Sharman, Joanna L, Faccenda, Elena, Southan, Chris, Pawson, Adam J, Ireland, Sam, Gray, Alasdair J G, Bruce, Liam, Alexander, Stephen P H, Anderton, Stephen, Bryant, Clare, Davenport, Anthony P, Doerig, Christian, Fabbro, Doriano, Levi-Schaffer, Francesca, Spedding, Michael, Davies, Jamie A

“…Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, www.guidetopharmacology.org) and its precursor IUPHAR-DB, have captured expert-curated interactions…”
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High-sensitivity cardiac troponin I at presentation in patients with suspected acute coronary syndrome: a cohort study by Shah, Anoop S V, Dr, Anand, Atul, MD, Sandoval, Yader, MD, Lee, Kuan Ken, MD, Smith, Stephen W, Prof, Adamson, Philip D, MD, Chapman, Andrew R, MD, Langdon, Timothy, MD, Sandeman, Dennis, MSc, Vaswani, Amar, MD, Strachan, Fiona E, PhD, Ferry, Amy, BSc, Stirzaker, Alexandra G, MD, Reid, Alan, MSc, Gray, Alasdair J, Prof, Collinson, Paul O, Prof, McAllister, David A, MD, Apple, Fred S, Prof, Newby, David E, Prof, Mills, Nicholas L, Prof

“…Summary Background Suspected acute coronary syndrome is the commonest reason for emergency admission to hospital and is a large burden on health-care…”
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Mechanistic biomarkers provide early and sensitive detection of acetaminophen‐induced acute liver injury at first presentation to hospital by Antoine, Daniel J., Dear, James W., Lewis, Philip Starkey, Platt, Vivien, Coyle, Judy, Masson, Moyra, Thanacoody, Ruben H., Gray, Alasdair J., Webb, David J., Moggs, Jonathan G., Bateman, D. Nicholas, Goldring, Christopher E., Park, B. Kevin

“…Acetaminophen overdose is a common reason for hospital admission and the most frequent cause of hepatotoxicity in the Western world. Early identification would…”
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High sensitivity cardiac troponin and the under-diagnosis of myocardial infarction in women: prospective cohort study by Shah, Anoop S V, Griffiths, Megan, Lee, Kuan Ken, McAllister, David A, Hunter, Amanda L, Ferry, Amy V, Cruikshank, Anne, Reid, Alan, Stoddart, Mary, Strachan, Fiona, Walker, Simon, Collinson, Paul O, Apple, Fred S, Gray, Alasdair J, Fox, Keith A A, Newby, David E, Mills, Nicholas L

“…Objective To evaluate the diagnosis of myocardial infarction using a high sensitivity troponin I assay and sex specific diagnostic thresholds in men and women…”
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PAV ontology: provenance, authoring and versioning by Ciccarese, Paolo, Soiland-Reyes, Stian, Belhajjame, Khalid, Gray, Alasdair Jg, Goble, Carole, Clark, Tim

“…Provenance is a critical ingredient for establishing trust of published scientific content. This is true whether we are considering a data set, a computational…”
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Delirium detection in older acute medical inpatients: a multicentre prospective comparative diagnostic test accuracy study of the 4AT and the confusion assessment method by Shenkin, Susan D, Fox, Christopher, Godfrey, Mary, Siddiqi, Najma, Goodacre, Steve, Young, John, Anand, Atul, Gray, Alasdair, Hanley, Janet, MacRaild, Allan, Steven, Jill, Black, Polly L, Tieges, Zoë, Boyd, Julia, Stephen, Jacqueline, Weir, Christopher J, MacLullich, Alasdair M J

“…Delirium affects > 15% of hospitalised patients but is grossly underdetected, contributing to poor care. The 4 'A's Test (4AT, www.the4AT.com ) is a short…”
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Comparison of the Efficacy and Safety of Early Rule-Out Pathways for Acute Myocardial Infarction by Chapman, Andrew R, Anand, Atul, Boeddinghaus, Jasper, Ferry, Amy V, Sandeman, Dennis, Adamson, Philip D, Andrews, Jack, Tan, Stephanie, Cheng, Sheun F, D'Souza, Michelle, Orme, Kate, Strachan, Fiona E, Nestelberger, Thomas, Twerenbold, Raphael, Badertscher, Patrick, Reichlin, Tobias, Gray, Alasdair, Shah, Anoop S V, Mueller, Christian, Newby, David E, Mills, Nicholas L

“…High-sensitivity cardiac troponin assays enable myocardial infarction to be ruled out earlier, but the optimal approach is uncertain. We compared the European…”
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The ROSE (Risk Stratification of Syncope in the Emergency Department) Study by Reed, Matthew J., MA, MB, BChir, MD, Newby, David E., PhD, DM, Coull, Andrew J., BSc, MB, ChB, MD, Prescott, Robin J., BSC, MSC, PhD, Jacques, Keith G., MB, BCh, Gray, Alasdair J., MB, ChB, MD

“…Objectives The aim of this study was to develop and validate a clinical decision rule (CDR) to predict 1-month serious outcome and all-cause death in patients…”
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FAIR in action - a flexible framework to guide FAIRification by Welter, Danielle, Juty, Nick, Rocca-Serra, Philippe, Xu, Fuqi, Henderson, David, Gu, Wei, Strubel, Jolanda, Giessmann, Robert T., Emam, Ibrahim, Gadiya, Yojana, Abbassi-Daloii, Tooba, Alharbi, Ebtisam, Gray, Alasdair J. G., Courtot, Melanie, Gribbon, Philip, Ioannidis, Vassilios, Reilly, Dorothy S., Lynch, Nick, Boiten, Jan-Willem, Satagopam, Venkata, Goble, Carole, Sansone, Susanna-Assunta, Burdett, Tony

“…The COVID-19 pandemic has highlighted the need for FAIR (Findable, Accessible, Interoperable, and Reusable) data more than any other scientific challenge to…”
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Patient selection for high sensitivity cardiac troponin testing and diagnosis of myocardial infarction: prospective cohort study by Shah, Anoop S V, Sandoval, Yader, Noaman, Ala, Sexter, Anne, Vaswani, Amar, Smith, Stephen W, Gibbins, Mathew, Griffiths, Megan, Chapman, Andrew R, Strachan, Fiona E, Anand, Atul, Denvir, Martin A, Adamson, Philip D, D’Souza, Michelle S, Gray, Alasdair J, McAllister, David A, Newby, David E, Apple, Fred S, Mills, Nicholas L

“…AbstractObjectiveTo evaluate how selection of patients for high sensitivity cardiac troponin testing affects the diagnosis of myocardial infarction across…”
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Albumin Versus Balanced Crystalloid for the Early Resuscitation of Sepsis: An Open Parallel-Group Randomized Feasibility Trial. The ABC-Sepsis Trial by Gray, Alasdair J, Oatey, Katherine, Grahamslaw, Julia, Irvine, Sîan, Cafferkey, John, Kennel, Titouan, Norrie, John, Walsh, Tim, Lone, Nazir, Horner, Daniel, Appelboam, Andy, Hall, Peter, Skipworth, Richard J E, Bell, Derek, Rooney, Kevin, Shankar-Hari, Manu, Corfield, Alasdair R

“…International guidelines recommend IV crystalloid as the primary fluid for sepsis resuscitation, with 5% human albumin solution (HAS) as the second line…”
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Interoperability and FAIRness through a novel combination of Web technologies by Wilkinson, Mark D, Verborgh, Ruben, Bonino da Silva Santos, Luiz Olavo, Clark, Tim, Swertz, Morris A, Kelpin, Fleur D.L, Gray, Alasdair J.G, Schultes, Erik A, van Mulligen, Erik M, Ciccarese, Paolo, Kuzniar, Arnold, Gavai, Anand, Thompson, Mark, Kaliyaperumal, Rajaram, Bolleman, Jerven T, Dumontier, Michel

“…Data in the life sciences are extremely diverse and are stored in a broad spectrum of repositories ranging from those designed for particular data types (such…”
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Troponin-Guided Coronary Computed Tomographic Angiography After Exclusion of Myocardial Infarction by Lee, Kuan Ken, Bularga, Anda, O'Brien, Rachel, Ferry, Amy V, Doudesis, Dimitrios, Fujisawa, Takeshi, Kelly, Shauna, Stewart, Stacey, Wereski, Ryan, Cranley, Denise, van Beek, Edwin J R, Lowe, David J, Newby, David E, Williams, Michelle C, Gray, Alasdair J, Mills, Nicholas L

“…Patients with suspected acute coronary syndrome in whom myocardial infarction has been excluded are at risk of future adverse cardiac events. This study…”
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Prevalence, Determinants, and Clinical Associations of High-Sensitivity Cardiac Troponin in Patients Attending Emergency Departments by Lee, Kuan Ken, Noaman, Ala, Vaswani, Amar, Gibbins, Matthew, Griffiths, Megan, Chapman, Andrew R., Strachan, Fiona, Anand, Atul, McAllister, David A., Newby, David E., Gray, Alasdair J., Mills, Nicholas L., Shah, Anoop S.V.

“…High-sensitivity cardiac troponin assays may improve the diagnosis of myocardial infarction but increase the detection of elevated cardiac troponin in patients…”
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Restrictive versus liberal blood transfusion for acute upper gastrointestinal bleeding (TRIGGER): a pragmatic, open-label, cluster randomised feasibility trial by Jairath, Vipul, Dr, Kahan, Brennan C, MSc, Gray, Alasdair, FCEM, Doré, Caroline J, BSc, Mora, Ana, PhD, James, Martin W, MRCP, Stanley, Adrian J, FRCP, Everett, Simon M, MRCP, Bailey, Adam A, FRACP, Dallal, Helen, FRCP, Greenaway, John, FRCP, Le Jeune, Ivan, MRCP, Darwent, Melanie, FCEM, Church, Nicholas, MRCP, Reckless, Ian, MRCP, Hodge, Renate, MSc, Dyer, Claire, BSc, Meredith, Sarah, MFPHM, Llewelyn, Charlotte, PhD, Palmer, Kelvin R, FRCP, Logan, Richard F, Prof, Travis, Simon P, FRCP, Walsh, Timothy S, Prof, Murphy, Michael F, Prof

“…Summary Background Transfusion thresholds for acute upper gastrointestinal bleeding are controversial. So far, only three small, underpowered studies and one…”
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Early Computed Tomography Coronary Angiography and Preventative Treatment in Patients with Suspected Acute Coronary Syndrome A secondary analysis of the RAPID-CTCA trial by Wang, Kang-Ling, Meah, Mohammed N, Bularga, Anda, Oatey, Katherine, O'Brien, Rachel, Smith, Jason E, Curzen, Nick, Kardos, Attila, Keating, Liza, Felmeden, Dirk, Storey, Robert F, Goodacre, Steve, Roobottom, Carl, Newby, David E, Gray, Alasdair J

“…: Computed tomography coronary angiography (CTCA) offers detailed assessment of the presence of coronary atherosclerosis and helps guide patient management. We…”
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The 4 'A's test for detecting delirium in acute medical patients: a diagnostic accuracy study by MacLullich, Alasdair Mj, Shenkin, Susan D, Goodacre, Steve, Godfrey, Mary, Hanley, Janet, Stíobhairt, Antaine, Lavender, Elizabeth, Boyd, Julia, Stephen, Jacqueline, Weir, Christopher, MacRaild, Allan, Steven, Jill, Black, Polly, Diernberger, Katharina, Hall, Peter, Tieges, Zoë, Fox, Christopher, Anand, Atul, Young, John, Siddiqi, Najma, Gray, Alasdair

“…Delirium is a common and serious neuropsychiatric syndrome, usually triggered by illness or drugs. It remains underdetected. One reason for this is a lack of…”
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Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial by Bateman, D Nicholas, Prof, Dear, James W, PhD, Thanacoody, H K Ruben, MD, Thomas, Simon H L, MD, Eddleston, Michael, PhD, Sandilands, Euan A, MB, Coyle, Judy, BSc, Cooper, Jamie G, MB, Rodriguez, Aryelly, MSc, Butcher, Isabella, PhD, Lewis, Steff C, PhD, Vliegenthart, A D Bastiaan, BSc, Veiraiah, Aravindan, MB, Webb, David J, Prof, Gray, Alasdair, MD

“…Summary Background Paracetamol poisoning is common worldwide. It is treated with intravenous acetylcysteine, but the standard regimen is complex and associated…”
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Dataset Descriptions for Linked Data Systems by Gray, Alasdair J.G.

“…Linked data systems rely on the quality of, and linking between, their data sources. However, existing data is difficult to trace to its origin and provides no…”
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API-centric Linked Data integration: The Open PHACTS Discovery Platform case study by Groth, Paul, Loizou, Antonis, Gray, Alasdair J.G., Goble, Carole, Harland, Lee, Pettifer, Steve

“…Data integration is a key challenge faced in pharmacology where there are numerous heterogeneous databases spanning multiple domains (e.g. chemistry and…”
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