Search Results - "Graves, T D"

Inflammation and Uncoupling as Mechanisms of Periodontal Bone Loss by Graves, D.T., Li, J., Cochran, D.L.

“…Periodontal disease is characterized by both inflammation and bone loss. Advances in research in both these areas have led to a new appreciation of not only…”
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The function of dendritic cells in modulating the host response by Song, L., Dong, G., Guo, L., Graves, D.T.

“…Summary Dendritic cells (DCs) are antigen‐presenting cells that capture, process, and present antigens to lymphocytes to initiate and regulate the adaptive…”
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Altered Fibroblast Proliferation and Apoptosis in Diabetic Gingival Wounds by Desta, T., Li, J., Chino, T., Graves, D.T.

“…Although it is known that diabetes impairs oral wound healing, relatively little is known about the cellular parameters affected, particularly in connective…”
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Molecular Mechanisms Controlling Bone Formation during Fracture Healing and Distraction Osteogenesis by AI-Aql, Z.S., Alagl, A.S., Graves, D.T., Gerstenfeld, L.C., Einhorn, T.A.

“…Fracture healing and distraction osteogenesis have important applications in orthopedic, maxillofacial, and periodontal treatment. In this review, the cellular…”
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Impaired wound healing in mouse models of diabetes is mediated by TNF-α dysregulation and associated with enhanced activation of forkhead box O1 (FOXO1) by Siqueira, M. F, Li, J, Chehab, L, Desta, T, Chino, T, Krothpali, N, Behl, Y, Alikhani, M, Yang, J, Braasch, C, Graves, D. T

“…Aims/hypothesis The role of TNF-α in impaired wound healing in diabetes was examined by focusing on fibroblasts. Methods Small excisional wounds were created…”
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Primary episodic ataxias: diagnosis, pathogenesis and treatment by Jen, J.C., Graves, T.D., Hess, E.J., Hanna, M.G., Griggs, R.C., Baloh, R.W.

“…Primary episodic ataxias are autosomal dominant channelopathies that manifest as attacks of imbalance and incoordination. Mutations in two genes, KCNA1 and…”
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A Cartesian grid embedded boundary method for solving the Poisson and heat equations with discontinuous coefficients in three dimensions by Crockett, R.K., Colella, P., Graves, D.T.

“…We present a method for solving Poisson and heat equations with discontinuous coefficients in two- and three-dimensions. It uses a Cartesian cut-cell/embedded…”
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Impaired Fracture Healing in the Absence of TNF‐α Signaling: The Role of TNF‐α in Endochondral Cartilage Resorption by Gerstenfeld, LC, Cho, T‐J, Kon, T, Aizawa, T, Tsay, A, Fitch, J, Barnes, GL, Graves, DT, Einhorn, TA

“…TNF‐α is a major inflammatory factor that is induced in response to injury, and it contributes to the normal regulatory processes of bone resorption. The role…”
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Diabetes Enhances Periodontal Bone Loss through Enhanced Resorption and Diminished Bone Formation by Liu, R., Bal, H.S., Desta, T., Krothapalli, N., Alyassi, M., Luan, Q., Graves, D.T.

“…Using a ligature-induced model in type-2 Zucker diabetic fatty (ZDF) rat and normoglycemic littermates, we investigated whether diabetes primarily affects…”
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IL-1 and TNF Antagonists Inhibit the Inflammatory Response and Bone Loss in Experimental Periodontitis by Assuma, R, Oates, T, Cochran, D, Amar, S, Graves, D. T

“…Periodontal disease is the most frequent cause of tooth loss in humans and is the most prevalent disease associated with bone loss, including osteoporosis…”
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BMP2 is essential for post natal osteogenesis but not for recruitment of osteogenic stem cells by Bais, M.V, Wigner, N, Young, M, Toholka, R, Graves, D.T, Morgan, E.F, Gerstenfeld, L.C, Einhorn, T.A

“…Abstract The effects of BMP2 on bone marrow stromal cell differentiation and bone formation after bone marrow ablation were determined using C57 BL/6J (B6)…”
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Diabetes-enhanced Inflammation and Apoptosis—Impact on Periodontal Pathology by Graves, D.T., Liu, R., Alikhani, M., Al-Mashat, H., Trackman, P.C.

“…Diabetes, particularly type 2 diabetes, is a looming health issue with many ramifications. Because diabetes alters the cellular microenvironment in many…”
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The Potential Role of Chemokines and Inflammatory Cytokines in Periodontal Disease Progression by Graves, D. T.

“…Inflammation is regulated by the expression of mediators that cause a number of pleiotropic events culminating in the recruitment of inflammatory cells and…”
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The Oral Microbiota Is Modified by Systemic Diseases by Graves, D.T., Corrêa, J.D., Silva, T.A.

“…Periodontal diseases are initiated by bacteria that accumulate in a biofilm on the tooth surface and affect the adjacent periodontal tissue. Systemic diseases…”
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Tumor necrosis factor alpha (TNF-α) coordinately regulates the expression of specific matrix metalloproteinases (MMPS) and angiogenic factors during fracture healing by Lehmann, W., Edgar, C.M., Wang, K., Cho, T-J., Barnes, G.L., Kakar, S., Graves, D.T., Rueger, J.M., Gerstenfeld, L.C., Einhorn, T.A.

“…Recent studies from our laboratory demonstrate that TNF-α signaling contributes to the regulation of chondrocyte apoptosis and a lack of TNF-α signaling leads…”
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Nongenetic factors influence severity of episodic ataxia type 1 in monozygotic twins by GRAVES, T. D, RAJAKULENDRAN, S, ZUBERI, S. M, MORRIS, H. R, SCHORGE, S, HANNA, M. G, KULLMANN, D. M

“…Episodic ataxia type 1 (EA1) is a monogenic channelopathy caused by mutations of the potassium channel gene KCNA1. Affected individuals carrying the same…”
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Inhibition of Experimental Periodontitis by a Topical Boron-based Antimicrobial by Luan, Q., Desta, T., Chehab, L., Sanders, V.J., Plattner, J., Graves, D.T.

“…AN0128 is a boron-containing compound with antibacterial and anti-inflammatory properties. To test its potential effectiveness in treating periodontal disease,…”
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Advanced Imaging in Dental Research: From Gene Mapping to AI Global Data by Graves, D T, Uribe, S E

“…Advances in imaging technologies combined with artificial intelligence (AI) are transforming dental, oral, and craniofacial research. This editorial highlights…”
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Establishment of oral bacterial communities in germ‐free mice and the influence of recipient age by Wu, Y.Y., Westwater, C., Xiao, E., Dias Corrêa, J., Xiao, W.M., Graves, D.T.

“…Summary The acquisition of the oral microbiome is a complex process. We examined how the timing of microbial exposure alters bacterial colonization of the…”
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Ion channels and epilepsy by GRAVES, T. D

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