Search Results - "Graves, Lee"

Evaluation of sit-stand workstations in an office setting: a randomised controlled trial by E F Graves, Lee, C Murphy, Rebecca, Shepherd, Sam O, Cabot, Josephine, Hopkins, Nicola D

“…Excessive sitting time is a risk factor for cardiovascular disease mortality and morbidity independent of physical activity. This aim of this study was to…”
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Enigmatic MELK: The controversy surrounding its complex role in cancer by McDonald, Ian M., Graves, Lee M.

“…The Ser/Thr protein kinase MELK (maternal embryonic leucine zipper kinase) has been considered an attractive therapeutic target for managing cancer since 2005…”
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The contribution of upper limb and total body movement to adolescents’ energy expenditure whilst playing Nintendo Wii by Graves, Lee E. F., Ridgers, Nicola D., Stratton, Gareth

“…Little research documents the contribution of upper limb and total body movement to energy expenditure (EE) during active video gaming. To address this, EE,…”
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Validity and reliability of subjective methods to assess sedentary behaviour in adults: a systematic review and meta-analysis by Bakker, Esmée A, Hartman, Yvonne A W, Hopman, Maria T E, Hopkins, Nicola D, Graves, Lee E F, Dunstan, David W, Healy, Genevieve N, Eijsvogels, Thijs M H, Thijssen, Dick H J

“…Subjective measures of sedentary behaviour (SB) (i.e. questionnaires and diaries/logs) are widely implemented, and can be useful for capturing type and context…”
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AUM302, a novel triple kinase PIM/PI3K/mTOR inhibitor, is a potent in vitro pancreatic cancer growth inhibitor by Ingle, Komala, LaComb, Joseph F, Graves, Lee M, Baines, Antonio T, Bialkowska, Agnieszka B

“…Pancreatic cancer is one of the leading causes of cancer deaths, with pancreatic ductal adenocarcinoma (PDAC) being the most common subtype. Advanced stage…”
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Chronic E-Cigarette Exposure Alters the Human Bronchial Epithelial Proteome by Ghosh, Arunava, Coakley, Raymond C, Mascenik, Teresa, Rowell, Temperance R, Davis, Eric S, Rogers, Keith, Webster, Megan J, Dang, Hong, Herring, Laura E, Sassano, M Flori, Livraghi-Butrico, Alessandra, Van Buren, Scott K, Graves, Lee M, Herman, Melissa A, Randell, Scott H, Alexis, Neil E, Tarran, Robert

“…E-cigarettes vaporize propylene glycol/vegetable glycerin (PG/VG), nicotine, and flavorings. However, the long-term health effects of exposing lungs to vaped…”
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Reference values for wrist-worn accelerometer physical activity metrics in England children and adolescents by Fairclough, Stuart J, Rowlands, Alex V, Del Pozo Cruz, Borja, Crotti, Matteo, Foweather, Lawrence, Graves, Lee E F, Hurter, Liezel, Jones, Owen, MacDonald, Mhairi, McCann, Deborah A, Miller, Caitlin, Noonan, Robert J, Owen, Michael B, Rudd, James R, Taylor, Sarah L, Tyler, Richard, Boddy, Lynne M

“…Over the last decade use of raw acceleration metrics to assess physical activity has increased. Metrics such as Euclidean Norm Minus One (ENMO), and Mean…”
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KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism by Vaseva, Angelina V., Blake, Devon R., Gilbert, Thomas S.K., Ng, Serina, Hostetter, Galen, Azam, Salma H., Ozkan-Dagliyan, Irem, Gautam, Prson, Bryant, Kirsten L., Pearce, Kenneth H., Herring, Laura E., Han, Haiyong, Graves, Lee M., Witkiewicz, Agnieszka K., Knudsen, Erik S., Pecot, Chad V., Rashid, Naim, Houghton, Peter J., Wennerberg, Krister, Cox, Adrienne D., Der, Channing J.

“…Our recent ERK1/2 inhibitor analyses in pancreatic ductal adenocarcinoma (PDAC) indicated ERK1/2-independent mechanisms maintaining MYC protein stability. To…”
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A multi-component intervention to sit less and move more in a contact centre setting: a feasibility study by Morris, Abigail S, Murphy, Rebecca C, Shepherd, Sam O, Healy, Genevieve N, Edwardson, Charlotte L, Graves, Lee E F

“…Call agents spend ~ 90% of their working day seated, which may negatively impact health, productivity, and wellbeing. This study aimed to explore the…”
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The physiological cost and enjoyment of Wii Fit in adolescents, young adults, and older adults by Graves, Lee E F, Ridgers, Nicola D, Williams, Karen, Stratton, Gareth, Atkinson, Greg, Cable, Nigel T

“…Active video games (exergames) increase energy expenditure (EE) and physical activity (PA) compared with sedentary video gaming. The physiological cost and…”
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Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer by Duncan, James S., Whittle, Martin C., Nakamura, Kazuhiro, Abell, Amy N., Midland, Alicia A., Zawistowski, Jon S., Johnson, Nancy L., Granger, Deborah A., Jordan, Nicole Vincent, Darr, David B., Usary, Jerry, Kuan, Pei-Fen, Smalley, David M., Major, Ben, He, Xiaping, Hoadley, Katherine A., Zhou, Bing, Sharpless, Norman E., Perou, Charles M., Kim, William Y., Gomez, Shawn M., Chen, Xin, Jin, Jian, Frye, Stephen V., Earp, H. Shelton, Graves, Lee M., Johnson, Gary L.

“…Kinase inhibitors have limited success in cancer treatment because tumors circumvent their action. Using a quantitative proteomics approach, we assessed kinome…”
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Inhibition of Lapatinib-induced Kinome Reprogramming in ERBB2-positive Breast Cancer by Targeting BET Family Bromodomains by Stuhlmiller, Timothy J., Miller, Samantha M., Zawistowski, Jon S., Nakamura, Kazuhiro, Beltran, Adriana S., Duncan, James S., Angus, Steven P., Collins, Kyla A.L, Granger, Deborah A., Reuther, Rachel A., Graves, Lee M., Gomez, Shawn M., Kuan, Pei-Fen, Parker, Joel S., Chen, Xin, Sciaky, Noah, Carey, Lisa A., Earp, H. Shelton, Jin, Jian, Johnson, Gary L.

“…Therapeutics such as lapatinib that target ERBB2 often provide initial clinical benefit but resistance frequently develops. Adaptive responses leading to…”
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A formative study exploring perceptions of physical activity and physical activity monitoring among children and young people with cystic fibrosis and health care professionals by Shelley, James, Fairclough, Stuart J, Knowles, Zoe R, Southern, Kevin W, McCormack, Pamela, Dawson, Ellen A, Graves, Lee E F, Hanlon, Claire

“…Physical activity (PA) is associated with reduced hospitalisations and maintenance of lung function in patients with Cystic Fibrosis (CF). PA is therefore…”
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The dynamic nature of the kinome by Graves, Lee M, Duncan, James S, Whittle, Martin C, Johnson, Gary L

“…Recent advances in proteomics have facilitated the analysis of the kinome 'en masse'. What these studies have revealed is a surprisingly dynamic network of…”
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Molecular Pathways: Adaptive Kinome Reprogramming in Response to Targeted Inhibition of the BRAF―MEK―ERK Pathway in Cancer by JOHNSON, Gary L, STUHLMILLER, Timothy J, ANGUS, Steven P, ZAWISTOWSKI, Jon S, GRAVES, Lee M

“…The central role of the BRAF-MEK-ERK pathway in controlling cell fate has made this pathway a primary target for deregulated activation in cancer. BRaf is…”
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Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability by Stratford, Jeran K, Yan, Feng, Hill, Rebecca A, Major, Michael B, Graves, Lee M, Der, Channing J, Yeh, Jen Jen

“…Pancreatic ductal adenocarcinoma, which accounts for the majority of pancreatic cancers, is a lethal disease with few therapeutic options. Genomic profiling of…”
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Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues by Graves, Paul R, Aponte-Collazo, Lucas J, Fennell, Emily M. J, Graves, Adam C, Hale, Andrew E, Dicheva, Nedyalka, Herring, Laura E, Gilbert, Thomas S. K, East, Michael P, McDonald, Ian M, Lockett, Matthew R, Ashamalla, Hani, Moorman, Nathaniel J, Karanewsky, Donald S, Iwanowicz, Edwin J, Holmuhamedov, Ekhson, Graves, Lee M

“…ONC201 is a first-in-class imipridone molecule currently in clinical trials for the treatment of multiple cancers. Despite enormous clinical potential, the…”
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Preliminary effects and acceptability of a co-produced physical activity referral intervention by Buckley, Benjamin JR, Thijssen, Dick HJ, Murphy, Rebecca C, Graves, Lee EF, Whyte, Greg, Gillison, Fiona, Crone, Diane, Wilson, Philip M, Hindley, Daniel, Watson, Paula M

“…Objectives: To explore the preliminary effects and acceptability of a co-produced physical activity referral intervention. Study Design: Longitudinal design…”
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Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers by Ozkan-Dagliyan, Irem, Diehl, J. Nathaniel, George, Samuel D., Schaefer, Antje, Papke, Bjoern, Klotz-Noack, Kathleen, Waters, Andrew M., Goodwin, Craig M., Gautam, Prson, Pierobon, Mariaelena, Peng, Sen, Gilbert, Thomas S.K., Lin, Kevin H., Dagliyan, Onur, Wennerberg, Krister, Petricoin, Emanuel F., Tran, Nhan L., Bhagwat, Shripad V., Tiu, Ramon V., Peng, Sheng-Bin, Herring, Laura E., Graves, Lee M., Sers, Christine, Wood, Kris C., Cox, Adrienne D., Der, Channing J.

“…We address whether combinations with a pan-RAF inhibitor (RAFi) would be effective in KRAS mutant pancreatic ductal adenocarcinoma (PDAC). Chemical library and…”
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Enhancer Remodeling during Adaptive Bypass to MEK Inhibition Is Attenuated by Pharmacologic Targeting of the P-TEFb Complex by Zawistowski, Jon S, Bevill, Samantha M, Goulet, Daniel R, Stuhlmiller, Timothy J, Beltran, Adriana S, Olivares-Quintero, Jose F, Singh, Darshan, Sciaky, Noah, Parker, Joel S, Rashid, Naim U, Chen, Xin, Duncan, James S, Whittle, Martin C, Angus, Steven P, Velarde, Sara Hanna, Golitz, Brian T, He, Xiaping, Santos, Charlene, Darr, David B, Gallagher, Kristalyn, Graves, Lee M, Perou, Charles M, Carey, Lisa A, Earp, H Shelton, Johnson, Gary L

“…Targeting the dysregulated BRAF-MEK-ERK pathway in cancer has increasingly emerged in clinical trial design. Despite clinical responses in specific cancers…”
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