Search Results - "Gravenfors, Ylva"

Rapid Construction of a Chloromethyl-Substituted Duocarmycin-like Prodrug by Bengtsson, Christoffer, Gravenfors, Ylva

“…The construction of duocarmycin-like compounds is often associated with lengthy synthetic routes. Presented herein is the development of a short and convenient…”
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Ultralarge Virtual Screening Identifies SARS-CoV‑2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses by Luttens, Andreas, Gullberg, Hjalmar, Abdurakhmanov, Eldar, Vo, Duy Duc, Akaberi, Dario, Talibov, Vladimir O, Nekhotiaeva, Natalia, Vangeel, Laura, De Jonghe, Steven, Jochmans, Dirk, Krambrich, Janina, Tas, Ali, Lundgren, Bo, Gravenfors, Ylva, Craig, Alexander J, Atilaw, Yoseph, Sandström, Anja, Moodie, Lindon W. K, Lundkvist, Åke, van Hemert, Martijn J, Neyts, Johan, Lennerstrand, Johan, Kihlberg, Jan, Sandberg, Kristian, Danielson, U. Helena, Carlsson, Jens

“…Drugs targeting SARS-CoV-2 could have saved millions of lives during the COVID-19 pandemic, and it is now crucial to develop inhibitors of coronavirus…”
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New Aminoimidazoles as β‑Secretase (BACE-1) Inhibitors Showing Amyloid‑β (Aβ) Lowering in Brain by Gravenfors, Ylva, Viklund, Jenny, Blid, Jan, Ginman, Tobias, Karlström, Sofia, Kihlström, Jacob, Kolmodin, Karin, Lindström, Johan, von Berg, Stefan, von Kieseritzky, Fredrik, Slivo, Can, Swahn, Britt-Marie, Olsson, Lise-Lotte, Johansson, Patrik, Eketjäll, Susanna, Fälting, Johanna, Jeppsson, Fredrik, Strömberg, Kia, Janson, Juliette, Rahm, Fredrik

“…Amino-2H-imidazoles are described as a new class of BACE-1 inhibitors for the treatment of Alzheimer’s disease. Synthetic methods, crystal structures, and…”
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Core Refinement toward Permeable β‑Secretase (BACE-1) Inhibitors with Low hERG Activity by Ginman, Tobias, Viklund, Jenny, Malmström, Jonas, Blid, Jan, Emond, Rikard, Forsblom, Rickard, Johansson, Anh, Kers, Annika, Lake, Fredrik, Sehgelmeble, Fernando, Sterky, Karin J, Bergh, Margareta, Lindgren, Anders, Johansson, Patrik, Jeppsson, Fredrik, Fälting, Johanna, Gravenfors, Ylva, Rahm, Fredrik

“…By use of iterative design aided by predictive models for target affinity, brain permeability, and hERG activity, novel and diverse compounds based on cyclic…”
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The Oncolytic Efficacy and in Vivo Pharmacokinetics of [2-(4-Chlorophenyl)quinolin-4-yl](piperidine-2-yl)methanol (Vacquinol-1) Are Governed by Distinct Stereochemical Features by Hammarström, Lars G. J, Harmel, Robert K, Granath, Mikael, Ringom, Rune, Gravenfors, Ylva, Färnegårdh, Katarina, Svensson, Per H, Wennman, David, Lundin, Göran, Roddis, Ylva, Kitambi, Satish S, Bernlind, Alexandra, Lehmann, Fredrik, Ernfors, Patrik

“…Glioblastoma remains an incurable brain cancer. Drugs developed in the past 20 years have not improved the prognosis for patients, necessitating the…”
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Discovery of novel pyrrolopyridazine scaffolds as transient receptor potential vanilloid (TRPV1) antagonists by Dorange, Ismet, Forsblom, Rickard, Macsari, Istvan, Svensson, Mats, Bylund, Johan, Besidski, Yevgeni, Blid, Jan, Sohn, Daniel, Gravenfors, Ylva

“…A novel indolizine class of compounds was identified as TRPV1 antagonist from an HTS campaign. However, this indolizine class proved to be unstable and reacted…”
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Creation of Novel Cores for β‑Secretase (BACE-1) Inhibitors: A Multiparameter Lead Generation Strategy by Viklund, Jenny, Kolmodin, Karin, Nordvall, Gunnar, Swahn, Britt-Marie, Svensson, Mats, Gravenfors, Ylva, Rahm, Fredrik

“…In order to find optimal core structures as starting points for lead optimization, a multiparameter lead generation workflow was designed with the goal of…”
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Phenyl isoxazole voltage-gated sodium channel blockers: Structure and activity relationship by Macsari, Istvan, Sandberg, Lars, Besidski, Yevgeni, Gravenfors, Ylva, Ginman, Tobias, Bylund, Johan, Bueters, Tjerk, Eriksson, Anders B, Lund, Per-Eric, Venyike, Elisabet, Arvidsson, Per I

“…Blocking of certain sodium channels is considered to be an attractive mechanism to treat chronic pain conditions. Phenyl isoxazole carbamate 1 was identified…”
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Correction to New Aminoimidazoles as β‑Secretase (BACE-1) Inhibitors Showing Amyloid‑β (Aβ) Lowering in Brain by Gravenfors, Ylva, Viklund, Jenny, Blid, Jan, Ginman, Tobias, Karlström, Sofia, Kihlström, Jacob, Kolmodin, Karin, Lindström, Johan, von Berg, Stefan, von Kieseritzky, Fredrik, Bogar, Krisztian, Slivo, Can, Swahn, Britt-Marie, Olsson, Lise-Lotte, Johansson, Patrik, Eketjäll, Susanna, Fälting, Johanna, Jeppsson, Fredrik, Strömberg, Kia, Janson, Juliette, Rahm, Fredrik

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Exploring the specificity of small molecules exhibiting anti-Abeta aggregating activity by Dahlqvist, Camilla, Hagstrom, Elin, Olsson, Rolf, Karlsson, Urban, Nyström, Sofie, Radesater, Ann-Cathrin, Simon, Sylvia, Nordvall, Gunnar, Gravenfors, Ylva, Lundkvist, Johan, Svensson, Samuel, Hammarström, Per

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P2‐226: Exploring the specificity of small molecules exhibiting anti‐Abeta aggregating activity by Dahlqvist, Camilla, Hagstrom, Elin, Olsson, Rolf, Karlsson, Urban, Nyström, Sofie, Radesater, Ann‐Cathrin, Simon, Sylvia, Nordvall, Gunnar, Gravenfors, Ylva, Lundkvist, Johan, Svensson, Samuel, Hammarström, Per

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