Topiramate treatment during the peripubertal period does not alter aortic endothelial function in female Wistar rats

This study aimed to evaluate the short- and long-term adverse effects of blood pressure (BP), vascular endothelial function, and estrogen receptor (ERα and ERβ) modulation on endothelial function in female Wistar rats treated with topiramate (TPM), an antiepileptic drug, during the peripubertal peri...

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Bibliographic Details
Published in:	Life sciences (1973) Vol. 327; p. 121819
Main Authors:	Silva, Deborah Gomes da, Moura, Kawane Fabricio, Souza, Amanda Cristina de, Silva, Kenny Gutemberg Nunes da, Vidigal, Camila Borecki, da Silva Jezuíno, Juliana, Gravena, Rafaella Cardoso, Pelosi, Gislaine Garcia, Gerardin, Daniela Cristina Ceccato, do Carmo Franco, Maria, Ceravolo, Graziela Scalianti
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 15-08-2023
Subjects:	Adolescents Endothelial dysfunction Female sex hormones Vascular reactivity Endothelial dysfunction Female sex hormones Vascular reactivity Adolescents
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Summary:	This study aimed to evaluate the short- and long-term adverse effects of blood pressure (BP), vascular endothelial function, and estrogen receptor (ERα and ERβ) modulation on endothelial function in female Wistar rats treated with topiramate (TPM), an antiepileptic drug, during the peripubertal period. Female Wistar rats were treated with TPM (41 mg/kg) or water (CTR group) by gavage from postnatal day (PND) 28 to 50 (peripubertal phase). At the end of the treatment, the TPM and CTR rats were divided into two groups and evaluated after 24 h or from PND 85 (adulthood). The rats were evaluated for: thoracic aorta reactivity to phenylephrine (Phenyl), acetylcholine (ACh), and sodium nitroprusside (SNP); aortic ring reactivity after ERα and ERβ antagonism; and BP. It was observed that vascular response to Phenyl, ACh, and SNP was similar between TPM and CTR rats in the short- and long-term evaluations. In addition, the ER antagonism did not interfere with aortic contraction or relaxation in either TPM or CTR. Taken together, the results show that TPM treatment during the peripubertal period does not alter aortic endothelial function and its estrogen modulation via classic ER in female Wistar rats, suggesting that TPM treatment in this period is safe for the vascular system. [Display omitted] •Endothelial function was preserved in female rats treated with topiramate during the peripubertal period.•Topiramate during the peripubertal period is safe for the vascular system of female rats in the short and long term.•Estrogen receptor blockade does not alter aortic response in female rats treated with topiramate.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0024-3205 1879-0631
DOI:	10.1016/j.lfs.2023.121819