Search Results - "Gravells, Polly"

Poly(ADP-Ribose) Glycohydrolase (PARG) vs. Poly(ADP-Ribose) Polymerase (PARP) – Function in Genome Maintenance and Relevance of Inhibitors for Anti-cancer Therapy by Harrision, Daniel, Gravells, Polly, Thompson, Ruth, Bryant, Helen E.

“…Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that catalyze the addition of poly(ADP-ribose) (PAR) subunits onto themselves and other acceptor…”
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Specific killing of DNA damage-response deficient cells with inhibitors of poly(ADP-ribose) glycohydrolase by Gravells, Polly, Grant, Emma, Smith, Kate M., James, Dominic I., Bryant, Helen E.

“…•A synthetic lethal screen for Poly(ADP-ribose)glycohydrolase (PARG) is presented.•SiRNA and the PARG inhibitors Gallotannin and PDD00017273 are used.•PARG is…”
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Radiosensitization with an inhibitor of poly(ADP-ribose) glycohydrolase: A comparison with the PARP1/2/3 inhibitor olaparib by Gravells, Polly, Neale, James, Grant, Emma, Nathubhai, Amit, Smith, Kate M., James, Dominic I., Bryant, Helen E.

“…[Display omitted] •PARG and PARP inhibition both radiosensitize.•PARP and PARG inhibition both alter the DNA damage response following irradiation (IR).•PARP…”
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MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma by King, David, Li, Xiao Dun, Almeida, Gilberto S, Kwok, Colin, Gravells, Polly, Harrison, Daniel, Burke, Saoirse, Hallsworth, Albert, Jamin, Yann, George, Sally, Robinson, Simon P, Lord, Christopher J, Poon, Evon, Yeomanson, Daniel, Chesler, Louis, Bryant, Helen E

“…This study investigates the influence expression of the MYCN oncogene has on the DNA damage response, replication fork progression and sensitivity to PARP…”
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Correction: MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma by King, David, Li, Xiao Dun, Almeida, Gilberto S, Kwok, Colin, Gravells, Polly, Harrison, Daniel, Burke, Saoirse, Hallsworth, Albert, Jamin, Yann, George, Sally, Robinson, Simon P, Lord, Christopher J, Poon, Evon, Yeomanson, Daniel, Chesler, Louis, Bryant, Helen E

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Increased Replication Stress Determines ATR Inhibitor Sensitivity in Neuroblastoma Cells by King, David, Southgate, Harriet E D, Roetschke, Saskia, Gravells, Polly, Fields, Leona, Watson, Jessica B, Chen, Lindi, Chapman, Devon, Harrison, Daniel, Yeomanson, Daniel, Curtin, Nicola J, Tweddle, Deborah A, Bryant, Helen E

“…Despite intensive high-dose multimodal therapy, high-risk neuroblastoma (NB) confers a less than 50% survival rate. This study investigates the role of…”
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Use of the HPRT gene to study nuclease-induced DNA double-strand break repair by Gravells, Polly, Ahrabi, Sara, Vangala, Rajani K, Tomita, Kazunori, Brash, James T, Brustle, Lena A, Chung, Christopher, Hong, Julia M, Kaloudi, Aikaterini, Humphrey, Timothy C, Porter, Andrew C G

“…Understanding the mechanisms of chromosomal double-strand break repair (DSBR) provides insight into genome instability, oncogenesis and genome engineering,…”
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Chemical genetic analyses of quantitative changes in Cdk1 activity during the human cell cycle by Gravells, Polly, Tomita, Kazunori, Booth, Alexander, Poznansky, Joshua, Porter, Andrew C G

“…Cyclin-dependent kinase 1 (Cdk1) controls cell proliferation and is inhibited by promising anticancer agents, but its mode of action and the consequences of…”
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Atypically low spontaneous sister chromatid exchange formation in uveal melanoma by Hoh, Leslie, Gravells, Polly, Canovas, David, Ul-Hassan, Aliya, Rennie, Ian G., Bryant, Helen, Sisley, Karen

“…Uveal melanoma (UM) is the most common primary intraocular cancer of adults and is characterized by several well‐established chromosomal changes. More…”
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