Ligature‐associated bacterial profiles are linked to type 2 diabetes mellitus in a rat model and influenced by antibody treatment against TNF‐α or RAGE

Ligature‐associated bacterial profiles are linked to type 2 diabetes mellitus in a rat model and influenced by antibody treatment against TNF‐α or RAGE

There is a bidirectional relationship between periodontal disease (PD) and type 2 diabetes mellitus (T2D). T2D may lead to ecological perturbations in the oral environment, which may facilitate an altered microbiota. However, previous studies have been inconclusive in determining the effect of T2D o...

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Bibliographic Details
Published in:Clinical and experimental dental research Vol. 3; no. 1; pp. 25 - 31
Main Authors: Grauballe, M.B., Belstrøm, D., Østergaard, J.A., Paster, B.J., Schou, S., Flyvbjerg, A., Holmstrup, P.
Format: Journal Article
Language:English
Published: United States John Wiley & Sons, Inc 01-02-2017
John Wiley and Sons Inc
Subjects:
Age
Animals
anti‐RAGE
anti‐TNF‐α
Biofilms
Chronic illnesses
Cytokines
Diabetes
diabetes mellitus
diabetes type 2
Disease
Glucose
Gum disease
Immunoglobulins
Laboratories
Microbiota
Original
Periodontal disease
Periodontitis
Rodents
stages
Studies
Tumor necrosis factor-TNF
Denmark
United States > US
Periodontal disease
Periodontitis
anti‐TNF‐α
stages
diabetes mellitus
diabetes type 2
anti‐RAGE
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Summary:There is a bidirectional relationship between periodontal disease (PD) and type 2 diabetes mellitus (T2D). T2D may lead to ecological perturbations in the oral environment, which may facilitate an altered microbiota. However, previous studies have been inconclusive in determining the effect of T2D on oral bacterial profiles. Therefore, we aimed to evaluate the influence of T2D on the ligature‐associated bacterial profile in a diabetic rat model with PD and investigated the impact of blocking inflammatory pathways with antibodies targeting either Tumor Necrosis Factor α (TNF‐α) or the receptor of advanced glycation end‐products (RAGE). A total of 62 Zucker obese rats (45 T2D) and 17 lean (non‐T2D) were divided into 4 treatment groups; lean with PD, obese with PD, obese with PD and anti‐TNF‐α treatment, and obese with PD with anti‐RAGE treatment. Periodontal disease was ligature induced. Ligature‐associated bacterial profiles were analyzed using Human Oral Microbe Identification Microarray (HOMIM). Ligature‐associated bacterial profiles differed between lean and obese rats. Furthermore, treatment with antibodies against TNF‐α or RAGE had an impact on subgingival bacterial profiles. T2D phenotypes are associated with different ligature‐associated bacterial profiles and influenced by treatment with antibodies against TNF‐α or RAGE.
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ISSN:2057-4347
2057-4347
DOI:10.1002/cre2.54