Search Results - "Gratton, J"

Prevalence of familial hypercholesterolaemia (FH)-causing variants and impact on LDL-C concentration in European, South Asian, and African ancestry groups of the UK Biobank by Gratton, J., Humphries, S.E., Futema, M.

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Regulation of endothelium-derived nitric oxide production by the protein kinase Akt by Sessa, William C, Fulton, David, Gratton, Jean-Philippe, McCabe, Timothy J, Fontana, Jason, Fujio, Yasushi, Walsh, Kenneth, Franke, Thomas F, Papapetropoulos, Andreas

“…Endothelial nitric oxide synthase (eNOS) is the nitric oxide synthase isoform responsible for maintaining systemic blood pressure, vascular remodelling and…”
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Implementing an obstetric triage acuity scale: interrater reliability and patient flow analysis by Smithson, David S., MD, Twohey, Rachel, MET, Rice, Tim, BScN, Watts, Nancy, MN, Fernandes, Christopher M., MD, Gratton, Robert J., MD

“…A 5-category Obstetric Triage Acuity Scale (OTAS) was developed with a comprehensive set of obstetrical determinants. The objectives of this study were as…”
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In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation by Sessa, William C, Bucci, Mariarosaria, Gratton, Jean-Philippe, Rudic, Radu Daniel, Acevedo, Lisette, Roviezzo, Fiorentina, Cirino, Giuseppe

“…Caveolin-1, the primary coat protein of caveolae, has been implicated as a regulator of signal transduction through binding of its "scaffolding domain" to key…”
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Atonic Postpartum Hemorrhage: Blood Loss, Risk Factors, and Third Stage Management by Lisonkova, Sarka, MD, PhD, Mehrabadi, Azar, PhD, Allen, Victoria M., MD, MSc, Bujold, Emmanuel, MD, MSc, Crane, Joan M.G., MD, MSc, Gaudet, Laura, MD, MSc, Gratton, Robert J., MD, Ladhani, Noor Niyar N., MD, MPH, Olatunbosun, Olufemi A., MD, Joseph, K.S., MD, PhD

“…Abstract Objective Atonic postpartum hemorrhage rates have increased in many industrialized countries in recent years. We examined the blood loss, risk…”
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Dual diagnosis of trisomy 21 and lethal perinatal Gaucher disease as a cause of non‐immune hydrops fetalis in a twin pregnancy for a consanguineous couple by Al Harthy, Talib, Colaiacovo, Samantha, Gratton, Robert J., Coughlin, Kevin, Siu, Victoria Mok, Prasad, Chitra, Rupar, Charles, Saleh, Maha

“…Key Clinical Message Non‐immune hydrops is a prenatal finding which can occur due to an underlying genetic diagnosis such as common chromosomal aneuploidy…”
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Modelling a two-stage screen for autosomal dominant familial hypercholesterolaemia (FH) in UK Biobank by Gratton, J., Humphries, S.E., Schmidt, A.F., Patel, R., Sofat, R., Finan, C., Hingorani, A.D., Futema, M.

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Acuity Assessment in Obstetrical Triage by Gratton, Robert J., MD, Bazaracai, Neila, BMSc, Cameron, Ian, BMSc, Watts, Nancy, RN, MN, PNC(C), Brayman, Colleen, RN, BScN, Hancock, Gregg, MD, Twohey, Rachel, MET, AlShanteer, Suhair, MD, MBBS, MScHIS, Ryder, Jennifer E., MHS, Wodrich, Kathryn, BScN, Williams, Emily, BScN, Guay, Amélie, RN, MSc, Basso, Melanie, RN, MSN, PNC(C), Smithson, David S., MD

“…Abstract Objective A five-category Obstetrical Triage Acuity Scale (OTAS) was developed with a comprehensive set of obstetrical determinants. The purposes of…”
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Customized Head Cushions Reduce Patient Movement During Intracranial Radiosurgery by Haridass, A, Vandervoort, E, Szanto, J, Sinclair, J, Gratton, J, Malone, K, Malone, S

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Post-translational control of endothelial nitric oxide synthase: why isn't calcium/calmodulin enough? by Fulton, D, Gratton, J P, Sessa, W C

“…Endothelial nitric oxide synthase (eNOS) is important for cardiovascular homeostasis, vessel remodeling, and angiogenesis. Given the impact of endothelium-…”
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Obstetrical intervention rates and maternal and neonatal outcomes of women with gestational hypertension by Gofton, E.N., Capewell, V., Natale, R., Gratton, R.J.

“…Objective: The purpose of this study was to determine the obstetrical intervention rates and maternal and neonatal outcomes of women with gestational…”
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Vascular endothelial growth factor-dependent down-regulation of Flk-1/KDR involves Cbl-mediated ubiquitination. Consequences on nitric oxide production from endothelial cells by Duval, Martine, Bédard-Goulet, Sara, Delisle, Chantal, Gratton, Jean-Philippe

“…Ligand-stimulated degradation of receptor tyrosine kinase (RTK) is an important regulatory step of signal transduction. The vascular endothelial growth factor…”
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Akt Down-regulation of p38 Signaling Provides a Novel Mechanism of Vascular Endothelial Growth Factor-mediated Cytoprotection in Endothelial Cells by Gratton, J P, Morales-Ruiz, M, Kureishi, Y, Fulton, D, Walsh, K, Sessa, W C

“…Vascular endothelial growth factor (VEGF) utilizes a phosphoinositide 3-kinase (PI 3-kinase)/Akt signaling pathway to protect endothelial cells from apoptotic…”
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The importance of the air temperature variable for the snowmelt runoff modelling using the SRM by Richard, C., Gratton, D. J.

“…Runoff regimes in most northern basins are controlled by the melting snow cover. A common method for evaluating runoff consists in correlating ambient air…”
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Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1 by Gratton, J P, Fontana, J, O'Connor, D S, Garcia-Cardena, G, McCabe, T J, Sessa, W C

“…The activity of endothelial nitric-oxide synthase (eNOS) is regulated by its subcellular localization, phosphorylation and through its interaction with…”
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Frequency of variants causing familial hypercholesterolaemia (FH) and impact on LDL-C concentration in individuals of South Asian and African ancestry in the UK Biobank by Futema, M., Humphries, S., Gratton, J.

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Adrenomedullin Messenger Ribonucleic Acid Expression in the Placentae of Normal and Preeclamptic Pregnancies by Gratton, R. J., Gluszynski, M., Mazzuca, D. M., Nygard, K., Han, V. K. M.

“…In pathological pregnancies, alterations in circulating maternal and fetal adrenomedullin (ADM) concentrations may mediate compensatory vascular responses in…”
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The Regional Expression of Insulin-like Growth Factor II (IGF-II) and Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) in the Placentae of Women with Pre-eclampsia by Gratton, R.J., Asano, H., Han, V.K.M.

“…Insulin-like growth factors and their binding proteins regulate cellular proliferation, differentiation and function, and play an important role in placental…”
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Molecular Factors Influencing Drug Transfer across the Blood-Brain Barrier by GRATTON, JULIE A., ABRAHAM, MICHAEL H., BRADBURY, MICHAEL W., CHADHA, HARPREET S.

“…A recently reported approach to the prediction of blood‐brain drug distribution uses the general linear free energy equation to correlate equilibrium…”
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Cell-permeable peptides improve cellular uptake and therapeutic gene delivery of replication-deficient viruses in cells and in vivo by Sessa, William C, Gratton, Jean-Philippe, Yu, Jun, Griffith, Jason W, Babbitt, Roger W, Scotland, Ramona S, Hickey, Reed, Giordano, Frank J

“…Small polybasic peptides derived from the transduction domains of certain proteins, such as the third α-helix of the Antennapedia (Antp) homeodomain, can cross…”
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