Search Results - "Gratton, E."

Number and Brightness analysis of alpha-synuclein oligomerization and the associated mitochondrial morphology alterations in live cells by Plotegher, N, Gratton, E, Bubacco, L

“…Alpha-synuclein oligomerization is associated to Parkinson's disease etiopathogenesis. The study of alpha-synuclein oligomerization properties in live cell and…”
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Comprehensive correlation analysis for super-resolution dynamic fingerprinting of cellular compartments using the Zeiss Airyscan detector by Scipioni, L., Lanzanó, L., Diaspro, A., Gratton, E.

“…The availability of the Airyscan detector in the Zeiss LSM 880 has made possible the development of a new concept in fluctuation correlation spectroscopy using…”
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An apolipoprotein-enriched biomolecular corona switches the cellular uptake mechanism and trafficking pathway of lipid nanoparticles by Digiacomo, L, Cardarelli, F, Pozzi, D, Palchetti, S, Digman, M A, Gratton, E, Capriotti, A L, Mahmoudi, M, Caracciolo, G

“…Following exposure to biological milieus (e.g. after systemic administration), nanoparticles (NPs) get covered by an outer biomolecular corona (BC) that…”
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effect of particle design on cellular internalization pathways by Gratton, Stephanie E.A, Ropp, Patricia A, Pohlhaus, Patrick D, Luft, J. Christopher, Madden, Victoria J, Napier, Mary E, DeSimone, Joseph M

“…The interaction of particles with cells is known to be strongly influenced by particle size, but little is known about the interdependent role that size,…”
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The structure of the deubiquitinase USP15 reveals a misaligned catalytic triad and an open ubiquitin-binding channel by Ward, Stephanie J., Gratton, Hayley E., Indrayudha, Peni, Michavila, Camille, Mukhopadhyay, Rishov, Maurer, Sigrun K., Caulton, Simon G., Emsley, Jonas, Dreveny, Ingrid

“…Ubiquitin-specific protease 15 (USP15) regulates important cellular processes, including transforming growth factor β (TGF-β) signaling, mitophagy, mRNA…”
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Spatial Characterization of Bioenergetics and Metabolism of Primordial to Preovulatory Follicles in Whole Ex Vivo Murine Ovary by Cinco, Rachel, Digman, Michelle A, Gratton, Enrico, Luderer, Ulrike

“…Previous work characterizing ovarian bioenergetics has defined follicular metabolism by measuring metabolic by-products in culture media. However, culture…”
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Mechanistic evaluation of the transfection barriers involved in lipid-mediated gene delivery: Interplay between nanostructure and composition by Pozzi, D., Marchini, C., Cardarelli, F., Salomone, F., Coppola, S., Montani, M., Zabaleta, M. Elexpuru, Digman, M.A., Gratton, E., Colapicchioni, V., Caracciolo, G.

“…Here we present a quantitative mechanism-based investigation aimed at comparing the cell uptake, intracellular trafficking, endosomal escape and final fate of…”
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The epidermal Ca(2+) gradient: Measurement using the phasor representation of fluorescent lifetime imaging by Celli, A, Sanchez, S, Behne, M, Hazlett, T, Gratton, E, Mauro, T

“…Ionic gradients are found across a variety of tissues and organs. In this report, we apply the phasor representation of fluorescence lifetime imaging data to…”
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Two Photon Fluorescence Microscopy of Coexisting Lipid Domains in Giant Unilamellar Vesicles of Binary Phospholipid Mixtures by Bagatolli, L.A., Gratton, E.

“…Images of giant unilamellar vesicles (GUVs) formed by different phospholipid mixtures (1,2-dipalmitoyl- sn-glycero-3-phosphocholine/1,2-dilauroyl-…”
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The Epidermal Ca2+ Gradient: Measurement Using the Phasor Representation of Fluorescent Lifetime Imaging by Celli, A., Sanchez, S., Behne, M., Hazlett, T., Gratton, E., Mauro, T.

“…Ionic gradients are found across a variety of tissues and organs. In this report, we apply the phasor representation of fluorescence lifetime imaging data to…”
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Microfabricated Particles for Engineered Drug Therapies: Elucidation into the Mechanisms of Cellular Internalization of PRINT Particles by Gratton, Stephanie E. A., Napier, Mary E., Ropp, Patricia A., Tian, Shaomin, DeSimone, Joseph M.

“…Purpose To investigate the cellular internalization pathways of shape- and size-specific particles as a function of zeta potential in different cell types…”
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Nanofabricated particles for engineered drug therapies: A preliminary biodistribution study of PRINT ™ nanoparticles by Gratton, Stephanie E.A., Pohlhaus, Patrick D., Lee, Jin, Guo, Ji, Cho, Moo J., DeSimone, Joseph M.

“…A novel method for the fabrication of polymeric particles on the order of tens of nanometers to several microns is described. This imprint lithographic…”
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AO DIVER: Development of a three-dimensional adaptive optics system to advance the depth limits of multiphoton imaging by Leemans, S., Dvornikov, A., Gallagher, T., Gratton, E.

“…Multiphoton microscopy (MPM) can non-invasively measure the dynamic biochemical properties deep in scattering biological samples and has the potential to…”
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The Pursuit of a Scalable Nanofabrication Platform for Use in Material and Life Science Applications by Gratton, Stephanie E. A, Williams, Stuart S, Napier, Mary E, Pohlhaus, Patrick D, Zhou, Zhilian, Wiles, Kenton B, Maynor, Benjamin W, Shen, Clifton, Olafsen, Tove, Samulski, Edward T, DeSimone, Joseph M

“…In this Account, we describe the use of perfluoropolyether (PFPE)-based materials that are able to accurately mold and replicate micro- and nanosized features…”
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Raster image correlation spectroscopy (RICS) for measuring fast protein dynamics and concentrations with a commercial laser scanning confocal microscope by BROWN, C.M, DALAL, R.B, HEBERT, B, DIGMAN, M.A, HORWITZ, A.R, GRATTON, E

“…Raster image correlation spectroscopy (RICS) is a new and novel technique for measuring molecular dynamics and concentrations from fluorescence confocal…”
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Lipid Rafts Reconstituted in Model Membranes by Dietrich, C., Bagatolli, L.A., Volovyk, Z.N., Thompson, N.L., Levi, M., Jacobson, K., Gratton, E.

“…One key tenet of the raft hypothesis is that the formation of glycosphingolipid- and cholesterol-rich lipid domains can be driven solely by characteristic…”
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Fluctuation Spectroscopy Analysis of Glucose Capped Gold Nanoparticles by Porcaro, F, Miao, Y, Kota, R, Haun, J. B, Polzonetti, G, Battocchio, C, Gratton, E

“…In this work, we report the synthesis and biophysical studies carried out on a new kind of biocompatible and very stable gold nanoparticle (GNP) stabilized…”
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Two-Photon Fluorescence Microscopy Observation of Shape Changes at the Phase Transition in Phospholipid Giant Unilamellar Vesicles by Bagatolli, L.A., Gratton, E.

“…Using the sectioning effect of the two-photon fluorescence microscope, we studied the behavior of phospholipid giant unilamellar vesicles (GUVs) composed of…”
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Experiences of parents and caregivers in pediatric intensive care units: A qualitative study by Durand, G., Branger, B., Durier, V., Liet, J.-M., Dabouis, G., Picherot, G., Cartron, E., Blache, S., Joram, E., Millasseau, F., Gratton, E., Guilbaud, V., Nizard, J., Bricaud, O., Gaillard-Le Roux, B.

“…In pediatric intensive care units (PICUs), parents and healthcare professionals attend to children who verbally and non-verbally express their pain and…”
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Fluctuation Methods To Study Protein Aggregation in Live Cells: Concanavalin A Oligomers Formation by Vetri, V., Ossato, G., Militello, V., Digman, M.A., Leone, M., Gratton, E.

“…Prefibrillar oligomers of proteins are suspected to be the primary pathogenic agents in several neurodegenerative diseases. A key approach for elucidating the…”
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