Search Results - "Grassly, Nicholas C."

Serotype-specific immunity explains the incidence of diseases caused by human enteroviruses by Pons-Salort, Margarita, Grassly, Nicholas C

“…Human enteroviruses are a major cause of neurological and other diseases. More than 100 serotypes are known that exhibit unexplained complex patterns of…”
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Mathematical models of infectious disease transmission by Grassly, Nicholas C, Fraser, Christophe

“…Key Points Mathematical analysis and modelling is an important part of infectious disease epidemiology. Application of mathematical models to disease…”
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Systematic review of mucosal immunity induced by oral and inactivated poliovirus vaccines against virus shedding following oral poliovirus challenge by Hird, Thomas R, Grassly, Nicholas C

“…Inactivated poliovirus vaccine (IPV) may be used in mass vaccination campaigns during the final stages of polio eradication. It is also likely to be adopted by…”
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The Burden of Typhoid and Paratyphoid in India: Systematic Review and Meta-analysis by John, Jacob, Van Aart, Carola J C, Grassly, Nicholas C

“…Typhoid is an important public health challenge for India, especially with the spread of antimicrobial resistance. The decision about whether to introduce a…”
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Seasonal infectious disease epidemiology by Grassly, N.C, Fraser, C

“…disease outbreaks, endemic dynamics and persistence. Finally, a mathematical analysis of routine and pulse vaccination programmes for seasonal infections is…”
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Interventions to improve oral vaccine performance: a systematic review and meta-analysis by Church, James A, Parker, Edward P, Kirkpatrick, Beth D, Grassly, Nicholas C, Prendergast, Andrew J

“…Oral vaccines underperform in low-income and middle-income countries compared with in high-income countries. Whether interventions can improve oral vaccine…”
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Influence of the intestinal microbiota on the immunogenicity of oral rotavirus vaccine given to infants in south India by Parker, Edward P.K., Praharaj, Ira, Zekavati, Anna, Lazarus, Robin P., Giri, Sidhartha, Operario, Darwin J., Liu, Jie, Houpt, Eric, Iturriza-Gómara, Miren, Kampmann, Beate, John, Jacob, Kang, Gagandeep, Grassly, Nicholas C.

“…Oral rotavirus vaccines have consistently proven to be less immunogenic among infants in developing countries. Discrepancies in the intestinal microbiota,…”
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Effect of a single inactivated poliovirus vaccine dose on intestinal immunity against poliovirus in children previously given oral vaccine: an open-label, randomised controlled trial by John, Jacob, MD, Giri, Sidhartha, MD, Karthikeyan, Arun S, MSc, Iturriza-Gomara, Miren, PhD, Muliyil, Jayaprakash, Prof, Abraham, Asha, Prof, Grassly, Nicholas C, Prof, Kang, Gagandeep, Prof

“…Summary Background Intestinal immunity induced by oral poliovirus vaccine (OPV) is imperfect and wanes with time, permitting transmission of infection by…”
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Influence of Enteric Infections on Response to Oral Poliovirus Vaccine: A Systematic Review and Meta-analysis by Parker, Edward P. K., Kampmann, Beate, Kang, Gagandeep, Grassly, Nicholas C.

“…Background. The impaired immunogenicity of oral poliovirus vaccine (OPV) in low-income countries has been apparent since the early field trials of this…”
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Changes in the intestinal microbiota following the administration of azithromycin in a randomised placebo-controlled trial among infants in south India by Parker, Edward P. K., Praharaj, Ira, John, Jacob, Kaliappan, Saravanakumar Puthupalayam, Kampmann, Beate, Kang, Gagandeep, Grassly, Nicholas C.

“…Macrolides are among the most widely prescribed antibiotics worldwide. However, their impact on the gut’s bacterial microbiota remains uncertain. We…”
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Efficacy of inactivated poliovirus vaccine in India by Jafari, Hamid, Deshpande, Jagadish M., Sutter, Roland W., Bahl, Sunil, Verma, Harish, Ahmad, Mohammad, Kunwar, Abhishek, Vishwakarma, Rakesh, Agarwal, Ashutosh, Jain, Shilpi, Estivariz, Concepcion, Sethi, Raman, Molodecky, Natalie A., Grassly, Nicholas C., Pallansch, Mark A., Chatterjee, Arani, Aylward, R. Bruce

“…Inactivated poliovirus vaccine (IPV) is efficacious against paralytic disease, but its effect on mucosal immunity is debated. We assessed the efficacy of IPV…”
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Reassessing Reported Deaths and Estimated Infection Attack Rate during the First 6 Months of the COVID-19 Epidemic, Delhi, India by Pons-Salort, Margarita, John, Jacob, Watson, Oliver J, Brazeau, Nicholas F, Verity, Robert, Kang, Gagandeep, Grassly, Nicholas C

“…India reported >10 million coronavirus disease (COVID-19) cases and 149,000 deaths in 2020. To reassess reported deaths and estimate incidence rates during the…”
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Changes in transmission of Enterovirus D68 (EV-D68) in England inferred from seroprevalence data by Pons-Salort, Margarita, Lambert, Ben, Kamau, Everlyn, Pebody, Richard, Harvala, Heli, Simmonds, Peter, Grassly, Nicholas C

“…The factors leading to the global emergence of Enterovirus D68 (EV-D68) in 2014 as a cause of acute flaccid myelitis (AFM) in children are unknown. To…”
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Effect of Inactivated Poliovirus Vaccine Campaigns, Pakistan, 2014-2017 by Grassly, Nicholas C, Wadood, Mufti Zubair, Safdar, Rana M, Mahamud, Abdirahman Sheikh, Sutter, Roland W

“…Pakistan began using inactivated poliovirus vaccine alongside oral vaccine in mass campaigns to accelerate eradication of wild-type poliovirus in 2014. Using…”
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Estimated Effect of Inactivated Poliovirus Vaccine Campaigns, Nigeria and Pakistan, January 2014-April 2016 by Shirreff, George, Wadood, Mufti Zubair, Vaz, Rui Gama, Sutter, Roland W, Grassly, Nicholas C

“…In 2014, inactivated poliovirus vaccine (IPV) campaigns were implemented in Nigeria and Pakistan after clinical trials showed that IPV boosts intestinal…”
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role of older children and adults in wild poliovirus transmission by Blake, Isobel M., Martin, Rebecca, Goel, Ajay, Khetsuriani, Nino, Everts, Johannes, Wolff, Christopher, Wassilak, Steven, Aylward, R. Bruce, Grassly, Nicholas C.

“…As polio eradication inches closer, the absence of poliovirus circulation in most of the world and imperfect vaccination coverage are resulting in immunity…”
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New Strategies for the Elimination of Polio from India by Grassly, Nicholas C., Fraser, Christophe, Wenger, Jay, Deshpande, Jagadish M., Sutter, Roland W., Heymann, David L., Aylward, R. Bruce

“…The feasibility of global polio eradication is being questioned as a result of continued transmission in a few localities that act as sources for outbreaks…”
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The effect of azithromycin on the immunogenicity of oral poliovirus vaccine: a double-blind randomised placebo-controlled trial in seronegative Indian infants by Grassly, Nicholas C, Prof, Praharaj, Ira, MD, Babji, Sudhir, MD, Kaliappan, Saravanakumar Puthupalayam, MSc, Giri, Sidhartha, MD, Venugopal, Srinivasan, MSc, Parker, Edward P K, BA, Abraham, Asha, Prof, Muliyil, Jayaprakash, Prof, Doss, Sridhar, BSc, Raman, Uma, MDS, Liu, Jie, PhD, Peter, John Victor, Prof, Paranjape, Meghana, MD, Jeyapaul, Shalini, MD, Balakumar, Shailaja, MD, Ravikumar, Jeniffer, MD, Srinivasan, Rajan, MD, Bahl, Sunil, MD, Iturriza-Gómara, Miren, Prof, Uhlig, Holm H, Prof, Houpt, Eric R, Prof, John, Jacob, Prof, Kang, Gagandeep, Prof

“…Summary Background Oral poliovirus vaccine is less immunogenic and effective in low-income countries than in high-income countries, similarly to other oral…”
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Implications of a Circulating Vaccine-Derived Poliovirus in Nigeria by Jenkins, Helen E, Aylward, R. Bruce, Gasasira, Alex, Donnelly, Christl A, Mwanza, Michael, Corander, Jukka, Garnier, Sandra, Chauvin, Claire, Abanida, Emmanuel, Pate, Muhammad Ali, Adu, Festus, Baba, Marycelin, Grassly, Nicholas C

“…Reversion of live attenuated oral poliovirus vaccine strains to a virulent phenotype is a rare but significant occurrence. In Nigeria, at least one…”
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Preventing Vaccine-Derived Poliovirus Emergence during the Polio Endgame by Pons-Salort, Margarita, Burns, Cara C, Lyons, Hil, Blake, Isobel M, Jafari, Hamid, Oberste, M Steven, Kew, Olen M, Grassly, Nicholas C

“…Reversion and spread of vaccine-derived poliovirus (VDPV) to cause outbreaks of poliomyelitis is a rare outcome resulting from immunisation with the…”
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