Search Results - "Grassilli, Emanuela"

“Ironing out” fasting-induced persister cancer cells to render chemotherapy effective: is this the solution? by Grassilli, Emanuela, Cerrito, Maria Grazia

Get full text

Identifying Novel Actionable Targets in Colon Cancer by Cerrito, Maria Grazia, Grassilli, Emanuela

“…Colorectal cancer is the fourth cause of death from cancer worldwide, mainly due to the high incidence of drug-resistance toward classic chemotherapeutic and…”
Get full text

BTK, the new kid on the (oncology) block? by Grassilli, Emanuela, Cerrito, Maria Grazia, Lavitrano, Marialuisa

“…In the last decade data piled up indicating that BTK – for twenty years considered as a “private matter” of bone marrow-derived cells – it is expressed and…”
Get full text

Inhibition of GSK3B Bypass Drug Resistance of p53-Null Colon Carcinomas by Enabling Necroptosis in Response to Chemotherapy by GRASSILLI, Emanuela, NARLOCH, Robert, DONADA, Marisa, STANTA, Giorgio, HELIN, Kristian, LAVITRANO, Marialuisa, FEDERZONI, Elena, IANZANO, Leonarda, PISANO, Fabio, GIOVANNONI, Roberto, ROMANO, Gabriele, MASIERO, Laura, LEONE, Biagio Eugenio, BONIN, Serena

“…Evasion from chemotherapy-induced apoptosis due to p53 loss strongly contributes to drug resistance. Identification of specific targets for the treatment of…”
Get full text

Influence of Bruton’s Tyrosine Kinase (BTK) on Epithelial–Mesenchymal Transition (EMT) Processes and Cancer Stem Cell (CSC) Enrichment in Head and Neck Squamous Cell Carcinoma (HNSCC) by Leichtle, Franziska, Betzler, Annika C., Eizenberger, Carlotta, Lesakova, Kristina, Ezić, Jasmin, Drees, Robert, Greve, Jens, Schuler, Patrick J., Laban, Simon, Hoffmann, Thomas K., Cordes, Nils, Lavitrano, Marialuisa, Grassilli, Emanuela, Brunner, Cornelia

“…Constitutively active kinases play a crucial role in carcinogenesis, and their inhibition is a common target for molecular tumor therapy. We recently…”
Get full text

Co-targeting triple-negative breast cancer cells and endothelial cells by metronomic chemotherapy inhibits cell regrowth and migration via downregulation of the FAK/VEGFR2/VEGF axis and autophagy/apoptosis activation by Scagliotti, Arianna, Capizzi, Laura, Cazzaniga, Marina Elena, Ilari, Alice, De Giorgi, Marco, Cordani, Nicoletta, Gallazzi, Matteo, Bruno, Antonino, Pelosi, Giuseppe, Albini, Adriana, Lavitrano, Marialuisa, Grassilli, Emanuela, Cerrito, Maria Grazia

“…High-dose standard-of-care chemotherapy is the only option for triple-negative breast cancer (TNBC) patients, which eventually die due to metastatic tumors…”
Get full text

p65BTK is a novel potential actionable target in KRAS-mutated/EGFR-wild type lung adenocarcinoma by Giordano, Federica, Vaira, Valentina, Cortinovis, Diego, Bonomo, Sara, Goedmakers, Joyce, Brena, Federica, Cialdella, Annamaria, Ianzano, Leonarda, Forno, Irene, Cerrito, Maria Grazia, Giovannoni, Roberto, Ferri, Gian Luca, Tasciotti, Ennio, Vicent, Silve, Damarco, Francesco, Bosari, Silvano, Lavitrano, Marialuisa, Grassilli, Emanuela

“…Lung cancer is still the main cause of cancer death worldwide despite the availability of targeted therapies and immune-checkpoint inhibitors combined with…”
Get full text

GSK3A is redundant with GSK3B in modulating drug resistance and chemotherapy-induced necroptosis by Grassilli, Emanuela, Ianzano, Leonarda, Bonomo, Sara, Missaglia, Carola, Cerrito, Maria Grazia, Giovannoni, Roberto, Masiero, Laura, Lavitrano, Marialuisa

“…Glycogen Synthase Kinase-3 alpha (GSK3A) and beta (GSK3B) isoforms are encoded by distinct genes, are 98% identical within their kinase domain and perform…”
Get full text

p65BTK Is a Novel Biomarker and Therapeutic Target in Solid Tumors by Grassilli, Emanuela, Cerrito, Maria Grazia, Bonomo, Sara, Giovannoni, Roberto, Conconi, Donatella, Lavitrano, Marialuisa

“…Bruton’s tyrosine kinase (BTK) is a non-receptor intracellular kinase playing a key role in the proliferation and survival of normal and malignant…”
Get full text

Differential Expression of NOTCH-1 and Its Molecular Targets in Response to Metronomic Followed by Conventional Therapy in a Patient with Advanced Triple-Negative Breast Cancer by Ilari, Alice, Cogliati, Viola, Sherif, Noorhan, Grassilli, Emanuela, Ramazzotti, Daniele, Cordani, Nicoletta, Cazzaniga, Giorgio, Di Bella, Camillo, Lavitrano, Marialuisa, Cazzaniga, Marina Elena, Cerrito, Maria Grazia

“…A group of 27 patients diagnosed with metastatic triple-negative breast cancer (mTNBC) was randomly distributed into two groups and underwent different lines…”
Get full text

Specific Expression of a New Bruton Tyrosine Kinase Isoform (p65BTK) in the Glioblastoma Gemistocytic Histotype by Sala, Luca, Cirillo, Giovanni, Riva, Gabriele, Romano, Gabriele, Giussani, Carlo, Cialdella, Annamaria, Todisco, Antonio, Virtuoso, Assunta, Cerrito, Maria Grazia, Bentivegna, Angela, Grassilli, Emanuela, Ardizzoia, Antonio, Bonoldi, Emanuela, Giovannoni, Roberto, Papa, Michele, Lavitrano, Marialuisa

“…Bruton's tyrosine-kinase (BTK) is a non-receptor tyrosine kinase recently associated with glioma tumorigenesis and a novel prognostic marker for poor survival…”
Get full text

Editorial: Targeting Bruton Tyrosine Kinase by Brunner, Cornelia, Betzler, Annika C, Brown, Jennifer R, Andreotti, Amy H, Grassilli, Emanuela

Get full text

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis by Müller, H, Bracken, A P, Vernell, R, Moroni, M C, Christians, F, Grassilli, E, Prosperini, E, Vigo, E, Oliner, J D, Helin, K

“…The retinoblastoma protein (pRB) and its two relatives, p107 and p130, regulate development and cell proliferation in part by inhibiting the activity of…”
Get full text

Multiple Signaling Pathways of the Insulin-Like Growth Factor 1 Receptor in Protection from Apoptosis by Peruzzi, Francesca, Prisco, Marco, Dews, Michael, Salomoni, Paolo, Grassilli, Emanuela, Romano, Gaetano, Calabretta, Bruno, Baserga, Renato

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Abstract LB-B06: p65BTK is a novel theranostic target in NSCLC by Grassilli, Emanuela

“…Abstract Recently we identified new targets to overcome drug resistance in colon cancer; in particular, we discovered and characterized p65BTK, a novel isoform…”
Get full text

Loss of MYC Confers Resistance to Doxorubicin-induced Apoptosis by Preventing the Activation of Multiple Serine Protease- and Caspase-mediated Pathways by Grassilli, Emanuela, Ballabeni, Andrea, Maellaro, Emilia, Del Bello, Barbara, Helin, Kristian

“…c-Myc plays an essential role in proliferation, differentiation, and apoptosis. Because of its relevance to cancer, most studies have focused on the cellular…”
Get full text

Emerging actionable targets to treat therapy-resistant colorectal cancers by Grassilli, Emanuela, Cerrito, Maria Grazia

“…In the last two decades major improvements have been reached in the early diagnosis of colorectal cancer (CRC) and, besides chemotherapy, an ampler choice of…”
Get full text

Mitochondrial modifications during rat thymocyte apoptosis: a study at the single cell level by Cossarizza, A, Kalashnikova, G, Grassilli, E, Chiappelli, F, Salvioli, S, Capri, M, Barbieri, D, Troiano, L, Monti, D, Franceschi, C

“…Apoptosis is an active type of cell death, occurring under several physiological and pathological conditions. The role of cellular organelles such as…”
Get more information

Autocrine Nerve Growth Factor Protects Human Keratinocytes from Apoptosis Through its High Affinity Receptor (TRK): A Role for BCL-2 by Pincelli, Carlo, Haake, Anne R., Benassi, Luisa, Grassilli, Emanuela, Magnoni, Cristina, Ottani, Daniela, Polakowska, Renata, Franceschi, Claudio, Giannetti, Alberto

“…Normal human keratinocytes synthesize and release nerve growth factor (NGF) and express both the low- and the high-affinity NGF receptor. Because NGF has been…”
Get full text

BCR-ABL Prevents c-Jun-Mediated and Proteasome-Dependent FUS (TLS) Proteolysis through a Protein Kinase CβII-Dependent Pathway by Perrotti, Danilo, Iervolino, Angela, Cesi, Vincenzo, Cirinná, Maria, Lombardini, Silvia, Grassilli, Emanuela, Bonatti, Silvia, Claudio, Pier Paolo, Calabretta, Bruno

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text