Search Results - "Grassi, Jeffrey M."

Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations by Von Moltke, Lisa L., Greenblatt, David J., Granda, Brian W., Duan, Su Xiang, Grassi, Jeffrey M., Venkatakrishnan, Karthik, Harmatz, Jerold S., Shader, Richard I.

“…Aims To determine the human cytochromes mediating biotransformation of the imidazopyridine hypnotic, zolpidem, and the clinical correlates of the findings…”
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INTERACTION OF TRIAZOLAM AND KETOCONAZOLE IN P-GLYCOPROTEIN-DEFICIENT MICE by VON MOLTKE, Lisa L, GRANDA, Brian W, GRASSI, Jeffrey M, PERLOFF, Michael D, VISHNUVARDHAN, Daesety, GREENBLATT, David J

“…The role of P-glycoprotein (P-gp) on the distribution of the benzodiazepine triazolam (TRZ) and the azole antifungal agent ketoconazole (KET), and on the…”
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Multiple Human Cytochromes Contribute to Biotransformation of Dextromethorphan In-vitro: Role of CYP2C9, CYP2C19, CYP2D6, and CYP3A by Von Moltke, Lisa L., Greenblatt, David J., Grassi, Jeffrey M., Granda, Brian W., Venkatakrishnan, Karthik, Schmider, JÜRgen, Harmatz, Jerold S., Shader, Richard I.

“…Cytochromes mediating the biotransformation of dextromethorphan to dextrorphan and 3‐methoxymorphinan, its principal metabolites in man, have been studied by…”
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Acute zolpidem administration produces pharmacodynamic and receptor occupancy changes at similar doses by Fahey, Jeanne M., Grassi, Jeffrey M., Reddi, Jyoti M., Greenblatt, David J.

“…Zolpidem is chemically unrelated to classical benzodiazepines but has demonstrated relatively high affinity binding to the α 1 GABA A receptor. To assess…”
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The effect of chronic lorazepam administration in aging mice by Fahey, Jeanne M., Pritchard, Gary A., Reddi, Jyoti M., Pratt, John S., Grassi, Jeffrey M., Shader, Richard I., Greenblatt, David J.

“…To assess benzodiazepine tolerance in aged animals, lorazepam or vehicle was administered chronically to male Crl: CD-1(ICR)BR mice. Pharmacodynamic and…”
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Citalopram and desmethylcitalopram in vitro: human cytochromes mediating transformation, and cytochrome inhibitory effects by von Moltke, Lisa L., Greenblatt, David J., Grassi, Jeffrey M., Granda, Brian W., Venkatakrishnan, Karthik, Duan, Su Xiang, Fogelman, Steven M., Harmatz, Jerold S., Shader, Richard I.

“…Background: Biotransformation of citalopram (CT), a newly available selective serotonin reuptake inhibitor antidepressant, to its principal metabolite,…”
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Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro : cytochromes mediating transformation, and P450-3A4 inhibitory actions by VON MOLTKE, L. L, GREENBLATT, D. J, GRANDA, B. W, GRASSI, J. M, SCHMIDER, J, HARMATZ, J. S, SHADER, R. I

“…Understanding of the mechanisms of biotransformation of antidepressant drugs, and of their capacity to interact with other medications, is of direct relevance…”
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Pharmacodynamic and receptor binding changes during chronic lorazepam administration by Fahey, Jeanne M, Pritchard, Gary A, Grassi, Jeffrey M, Pratt, John S, Shader, Richard I, Greenblatt, David J

“…To assess pharmacodynamic and neurochemical aspects of tolerance, lorazepam (2 mg/kg/day), or vehicle was administered chronically to male Crl: CD-1(ICR)BR…”
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Effects of ketoconazole on triazolam pharmacokinetics, pharmacodynamics and benzodiazepine receptor binding in mice by Fahey, J M, Pritchard, G A, Moltke, L L, Pratt, J S, Grassi, J M, Shader, R I, Greenblatt, D J

“…We previously demonstrated that ketoconazole is a potent inhibitor of triazolam biotransformation in vitro and in vivo. Despite significant elevations in…”
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In situ hybridization histochemistry as a method to assess GABAAreceptor subunit mRNA expression following chronic alprazolam administration by Fahey, Jeanne M., Pritchard, Gary A., Grassi, Jeffrey M., Pratt, John S., Shader, Richard I., Greenblatt, David J.

“…Previous work in our laboratory has demonstrated region-specic effects for chronic alprazolam on binding and function at the GABAA receptor. The present study…”
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Protease Inhibitors as Inhibitors of Human Cytochromes P450: High Risk Associated with Ritonavir by von Moltke, Lisa L., Greenblatt, David J., Grassi, Jeffrey M., Granda, Brian W., Duan, Su Xiang, Fogelman, Steven M., Daily, Johanna P., Harmatz, Jerold S., Shader, Richard I.

“…Four protease inhibitor antiviral agents (ritonavir, indinavir, nelfinavir, saquinavir) were evaluated as in vitro inhibitors of the activity of six human…”
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In situ hybridization histochemistry as a method to assess GABA(A) receptor subunit mRNA expression following chronic alprazolam administration by Fahey, J M, Pritchard, G A, Grassi, J M, Pratt, J S, Shader, R I, Greenblatt, D J

“…Previous work in our laboratory has demonstrated region-specific effects for chronic alprazolam on binding and function at the GABA(A) receptor. The present…”
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Appetite suppressant drugs as inhibitors of human cytochromes p450 : In vitro inhibition of P450-2D6 by D- and L-fenfluramine, but not phentermine by VON MOLTKE, L. L, GREENBLATT, D. J, CIRAULO, D. A, GRASSI, J. M, GRANDA, B. W, SU XIANG DUAN, HARMATZ, J. S, SHADER, R. I

“…The activity of D-fenfluramine, L-fenfluramine, and phentermine as inhibitors of five human cytochromes P450 was evaluated using human liver microsomes in…”
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