Search Results - "Grasset, E K"

Gut T cell-independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells by Grasset, E K, Chorny, A, Casas-Recasens, S, Gutzeit, C, Bongers, G, Thomsen, I, Chen, L, He, Z, Matthews, D B, Oropallo, M A, Veeramreddy, P, Uzzan, M, Mortha, A, Carrillo, J, Reis, B S, Ramanujam, M, Sintes, J, Magri, G, Maglione, P J, Cunningham-Rundles, C, Bram, R J, Faith, J, Mehandru, S, Pabst, O, Cerutti, A

“…The gut mounts secretory immunoglobulin A (SIgA) responses to commensal bacteria through nonredundant T cell-dependent (TD) and T cell-independent (TI)…”
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Rethinking mucosal antibody responses: IgM, IgG and IgD join IgA by Chen, Kang, Magri, Giuliana, Grasset, Emilie K., Cerutti, Andrea

“…Humoral immune responses at mucosal surfaces have historically focused on IgA. Growing evidence highlights the complexity of IgA-inducing pathways and the…”
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Fecal IgA Levels Are Determined by Strain-Level Differences in Bacteroides ovatus and Are Modifiable by Gut Microbiota Manipulation by Yang, Chao, Mogno, Ilaria, Contijoch, Eduardo J., Borgerding, Joshua N., Aggarwala, Varun, Li, Zhihua, Siu, Sophia, Grasset, Emilie K., Helmus, Drew S., Dubinsky, Marla C., Mehandru, Saurabh, Cerutti, Andrea, Faith, Jeremiah J.

“…Fecal IgA production depends on colonization by a gut microbiota. However, the bacterial strains that drive gut IgA production remain largely unknown. Here, we…”
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Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals by Magri, Giuliana, Comerma, Laura, Pybus, Marc, Sintes, Jordi, Lligé, David, Segura-Garzón, Daniel, Bascones, Sabrina, Yeste, Ada, Grasset, Emilie K., Gutzeit, Cindy, Uzzan, Mathieu, Ramanujam, Meera, van Zelm, Menno C., Albero-González, Raquel, Vazquez, Ivonne, Iglesias, Mar, Serrano, Sergi, Márquez, Lucía, Mercade, Elena, Mehandru, Saurabh, Cerutti, Andrea

“…Secretory immunoglobulin A (SIgA) enhances host-microbiota symbiosis, whereas SIgM remains poorly understood. We found that gut IgM+ plasma cells (PCs) were…”
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Secreted IgD Amplifies Humoral T Helper 2 Cell Responses by Binding Basophils via Galectin-9 and CD44 by Shan, Meimei, Carrillo, Jorge, Yeste, Ada, Gutzeit, Cindy, Segura-Garzón, Daniel, Walland, A. Cooper, Pybus, Marc, Grasset, Emilie K., Yeiser, John R., Matthews, Dean B., van de Veen, Willem, Comerma, Laura, He, Bing, Boonpiyathad, Tadech, Lee, Haekyung, Blanco, Julià, Osborne, Lisa C., Siracusa, Mark C., Akdis, Mübeccel, Artis, David, Mehandru, Saurabh, Sampson, Hugh A., Berin, M. Cecilia, Chen, Kang, Cerutti, Andrea

“…B cells thwart antigenic aggressions by releasing immunoglobulin M (IgM), IgG, IgA, and IgE, which deploy well-understood effector functions. In contrast, the…”
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mTOR intersects antibody-inducing signals from TACI in marginal zone B cells by Sintes, Jordi, Gentile, Maurizio, Zhang, Shuling, Garcia-Carmona, Yolanda, Magri, Giuliana, Cassis, Linda, Segura-Garzón, Daniel, Ciociola, Alessandra, Grasset, Emilie K., Bascones, Sabrina, Comerma, Laura, Pybus, Marc, Lligé, David, Puga, Irene, Gutzeit, Cindy, He, Bing, DuBois, Wendy, Crespo, Marta, Pascual, Julio, Mensa, Anna, Aróstegui, Juan Ignacio, Juan, Manel, Yagüe, Jordi, Serrano, Sergi, Lloreta, Josep, Meffre, Eric, Hahne, Michael, Cunningham-Rundles, Charlotte, Mock, Beverly A., Cerutti, Andrea

“…Mechanistic target of rapamycin (mTOR) enhances immunity in addition to orchestrating metabolism. Here we show that mTOR coordinates immunometabolic…”
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Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response by Grasset, Emilie K., Duhlin, Amanda, Agardh, Hanna E., Ovchinnikova, Olga, Hägglöf, Thomas, Forsell, Mattias N., Paulsson-Berne, Gabrielle, Hansson, Göran K., Ketelhuth, Daniel F. J., Karlsson, Mikael C. I.

“…The B-cell response in atherosclerosis is directed toward oxidation-specific epitopes such as phosphorylcholine (PC) that arise during disease-driven oxidation…”
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CD36 regulates B-cell response in the systemic lupus erythematosus by He, C, Duhlin, A, Grasset, EK, Karlsson, M

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BAFF-driven B cell hyperplasia underlies lung disease in common variable immunodeficiency by Maglione, Paul J, Gyimesi, Gavin, Cols, Montserrat, Radigan, Lin, Ko, Huaibin M, Weinberger, Tamar, Lee, Brian H, Grasset, Emilie K, Rahman, Adeeb H, Cerutti, Andrea, Cunningham-Rundles, Charlotte

“…Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency and is frequently complicated by interstitial lung disease…”
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inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells by Enoksson, Sara Lind, Grasset, Emilie K, Hägglöf, Thomas, Mattsson, Nina, Kaiser, Ylva, Gabrielsson, Susanne, McGaha, Tracy L, Scheynius, Annika, Karlsson, Mikael C. I

“…Inflammatory responses initiate rapid production of IL-1 family cytokines, including IL-18. This cytokine is produced at high levels in inflammatory diseases,…”
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Scavenger receptor CD36 on B cells senses modified self-antigens to prevent autoimmunity by Duhlin, Amanda, Grasset, Emilie K, He, Chenfei, Amara, Khaled, Sippl, Natalie, Lindh, Emma, Vargas, Leonardo, Dahlberg, Carin, Westerberg, Lisa, Smith, Edvard CI, Malmström, Vivianne, Pierce, Susan K, Karlsson, Mikael C

“…Abstract Scavenger receptor CD36 has been shown to mediate uptake of modified self-antigens such as apoptotic cells and oxidized LDL in macrophages and…”
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Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies by Dahlberg, Carin I.M, Torres, Magda-Liz, Petersen, Sven H, Baptista, Marisa A.P, Keszei, Marton, Volpi, Stefano, Grasset, Emilie K, Karlsson, Mikael C.I, Walter, Jolan E, Snapper, Scott B, Notarangelo, Luigi D, Westerberg, Lisa S

“…Abstract Humoral immunodeficiency caused by mutations in the Wiskott-Aldrich syndrome protein (WASp) is associated with failure to respond to common pathogens…”
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BLyS-mediated modulation of naive B cell subsets impacts HIV Env-induced antibody responses by Dosenovic, Pia, Soldemo, Martina, Scholz, Jean L, O'Dell, Sijy, Grasset, Emilie K, Pelletier, Nadège, Karlsson, Mikael C I, Mascola, John R, Wyatt, Richard T, Cancro, Michael P, Karlsson Hedestam, Gunilla B

“…Neutralizing Abs provide the protective effect of the majority of existing human vaccines. For a prophylactic vaccine against HIV-1, broadly neutralizing Abs…”
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CD36 regulates B-cell response in the systemic lupus erythematosus by Duhlin, A, He, CF, Grasset, EK, Vargas, L, Dahlberg, C, Westerberg, LS, Smith, ECI, Pierce, SK, Karlsson, MCI

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Sterile Inflammation in the Spleen Provides Oxidation-specific Epitopes that Induce an Atheroprotective B Cell Response by Grasset, EK, Agardh, HE, Duhlin, A, Forsell, MN, Hagglof, T, Hansson, GK, Ketelhuth, DFJ, Paulsson-Berne, G, Karlsson, MCI

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Deletion of WASp and N-WASp in B Cells Cripple the Germinal Center Response and Induces Production of IgM Autoantibodies by Dahlberg, CIM, Torres, ML, Petersen, SH, Baptista, MAP, Keszei, M, Volpi, S, Grasset, EK, Karlsson, MCI, Walter, JE, Snapper, SB, Notarangelo, LD, Westerberg, LS

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