Powder flow and mixing in different tablet press feed frames

Powder flow and mixing in different tablet press feed frames

[Display omitted] •DEM (discrete element method) simulations of three different feed frames.•Varying rotational rates and powder properties (several million particles).•Analysis of residence time distributions and tablet masses.•Clear differences in the performance between the devices. Tablets can b...

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Bibliographic Details
Published in:Advanced powder technology : the international journal of the Society of Powder Technology, Japan Vol. 31; no. 2; pp. 770 - 781
Main Authors: Siegmann, Eva, Forgber, Thomas, Toson, Peter, Martinetz, Michael C., Kureck, Hermann, Brinz, Thomas, Manz, Stefan, Grass, Torsten, Khinast, Johannes
Format: Journal Article
Language:English
Published: Elsevier B.V 01-02-2020
Subjects:
Discrete element method
Feed frame
Granular flow
Incomplete die filling
Residence time analysis
RTD
Tablet press
Tablet weight homogeneity
FF
STD
Feed frame
RTD
Residence time analysis
Discrete element method
Tablet weight homogeneity
GPU
MRT
CQA
Incomplete die filling
CMA
XPS
LSD
2P
PSD
Granular flow
DEM
MEPA
CCP
QbD
API
Tablet press
3P
1P
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Summary:[Display omitted] •DEM (discrete element method) simulations of three different feed frames.•Varying rotational rates and powder properties (several million particles).•Analysis of residence time distributions and tablet masses.•Clear differences in the performance between the devices. Tablets can be manufactured using a rotary tablet press, which consists of a feed frame followed by the compression and compaction of the powder and subsequent ejection of the tablets. From Quality by Design (QbD) perspectives the feed frame plays a critical role and effects products critical quality attributes (CQAs). Thus optimizing this stage is of huge interest. It is preferable to achieve narrow residence time distributions of the powder in the feed frames as well as homogeneous tablets with respect to their height, weight and tensile strength. In the present study three design approaches of feed frames are simulated using the Discrete Element Method (DEM). We investigate the influence of operational input parameters (i.e., rotational rates) on the behaviour of a free flowing and a cohesive material. The detailed simulation data allows us to compare the mentioned setups in terms of residence times, tablet masses and occurring deviations. Therefore, we are able to determine the optimal feed frame and process settings for both free-flowing and cohesive powders.
ISSN:0921-8831
1568-5527
DOI:10.1016/j.apt.2019.11.031