Search Results - "Grasberger, Helmut"

Genetic causes of congenital hypothyroidism due to dyshormonogenesis by Grasberger, Helmut, Refetoff, Samuel

“…Overview of congenital hypothyroidism caused by thyroid hormone synthesis defects, the current understanding of their pathophysiology, and clinical…”
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Resistance to thyrotropin by Grasberger, Helmut, M.D, Refetoff, Samuel, M.D

“…Abstract Resistance to thyrotropin (RTSH) is broadly defined as reduced sensitivity of thyroid follicle cells to stimulation by biologically active TSH due to…”
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The Cxcr2+ subset of the S100a8+ gastric granylocytic myeloid-derived suppressor cell population (G-MDSC) regulates gastric pathology by Kao, Krystal D., Grasberger, Helmut, El-Zaatari, Mohamad

“…Introduction Gastric myeloid-derived suppressor cells (MDSCs) are a prominent population that expands during gastric pre-neoplastic and neoplastic development…”
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DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses by Lipinski, Simone, Till, Andreas, Sina, Christian, Arlt, Alexander, Grasberger, Helmut, Schreiber, Stefan, Rosenstiel, Philip

“…Generation of microbicidal reactive oxygen species (ROS) is a pivotal protective component of the innate immune system in many eukaryotes. NOD (nucleotide…”
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Essential Role of NADPH Oxidase-Dependent Production of Reactive Oxygen Species in Maintenance of Sustained B Cell Receptor Signaling and B Cell Proliferation by Feng, Yang-Yang, Tang, Miao, Suzuki, Mitsuhiro, Gunasekara, Chinthika, Anbe, Yuki, Hiraoka, Yuichi, Liu, Jun, Grasberger, Helmut, Ohkita, Mamoru, Matsumura, Yasuo, Wang, Ji-Yang, Tsubata, Takeshi

“…Reactive oxygen species (ROS) are not only toxic substances inducing oxidative stress but also play a role as a second messenger in signal transduction through…”
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Increased Expression of DUOX2 Is an Epithelial Response to Mucosal Dysbiosis Required for Immune Homeostasis in Mouse Intestine by Grasberger, Helmut, Gao, Jun, Nagao-Kitamoto, Hiroko, Kitamoto, Sho, Zhang, Min, Kamada, Nobuhiko, Eaton, Kathryn A, El-Zaatari, Mohamad, Shreiner, Andrew B, Merchant, Juanita L, Owyang, Chung, Kao, John Y

“…Background & Aims Dual oxidase 2 (DUOX2), a hydrogen-peroxide generator at the apical membrane of gastrointestinal epithelia, is up-regulated in patients with…”
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Effects of Anti– Helicobacter pylori Therapy on Incidence of Autoimmune Diseases, Including Inflammatory Bowel Diseases by Lin, Kun-Der, Chiu, Guei-Fen, Waljee, Akbar K, Owyang, Stephanie Y, El-Zaatari, Mohamad, Bishu, Shrinivas, Grasberger, Helmut, Zhang, Min, Wu, Deng-Chyang, Kao, John Y

“…Background & AimsHelicobacter pylori induces immune tolerance and is associated with a lower risk for immune-mediated disorders, such as autoimmune and…”
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Dual Oxidases Control Release of Hydrogen Peroxide by the Gastric Epithelium to Prevent Helicobacter felis Infection and Inflammation in Mice by Grasberger, Helmut, El–Zaatari, Mohamad, Dang, Duyen T, Merchant, Juanita L

“…Background & Aims Dual oxidases (DUOX) are conserved reduced nicotinamide adenine dinucleotide phosphate oxidases that produce H2 O2 at the epithelial cell…”
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Functional Characterization of Inflammatory Bowel Disease–Associated Gut Dysbiosis in Gnotobiotic Mice by Nagao-Kitamoto, Hiroko, Shreiner, Andrew B, Gillilland, Merritt G, Kitamoto, Sho, Ishii, Chiharu, Hirayama, Akiyoshi, Kuffa, Peter, El-Zaatari, Mohamad, Grasberger, Helmut, Seekatz, Anna M, Higgins, Peter D.R, Young, Vincent B, Fukuda, Shinji, Kao, John Y, Kamada, Nobuhiko

“…Background & Aims Gut dysbiosis is closely involved in the pathogenesis of inflammatory bowel disease (IBD). However, it remains unclear whether IBD-associated…”
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Mice Deficient in Dual Oxidase Maturation Factors Are Severely Hypothyroid by Grasberger, Helmut, De Deken, Xavier, Mayo, Olga Barca, Raad, Houssam, Weiss, Mia, Liao, Xiao-Hui, Refetoff, Samuel

“…Dual oxidases (DUOX1 and DUOX2) are evolutionary conserved reduced nicotinamide adenine dinucleotide phosphate oxidases responsible for regulated hydrogen…”
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Increased risk for inflammatory bowel disease in congenital hypothyroidism supports the existence of a shared susceptibility factor by Grasberger, Helmut, Noureldin, Mohamed, Kao, Timothy D., Adler, Jeremy, Lee, Joyce M., Bishu, Shrinivas, El-Zaatari, Mohamad, Kao, John Y., Waljee, Akbar K.

“…Loss-of-function mutations in dual oxidase (DUOX) 2 are the most common genetic variants found in congenital hypothyroidism (CH), and similar mutations have…”
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Biallelic Inactivation of the Dual Oxidase Maturation Factor 2 (DUOXA2) Gene as a Novel Cause of Congenital Hypothyroidism by Zamproni, Ilaria, Grasberger, Helmut, Cortinovis, Francesca, Vigone, Maria Cristina, Chiumello, Giuseppe, Mora, Stefano, Onigata, Kazumichi, Fugazzola, Laura, Refetoff, Samuel, Persani, Luca, Weber, Giovanna

“…Context: Dual oxidase 2 (DUOX2) is the catalytic core of the H2O2 generator crucial for the iodination of thyroglobulin in thyroid hormone synthesis. DUOX2…”
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Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium by Chu, Fong-Fong, Esworthy, R. Steven, Doroshow, James H., Grasberger, Helmut, Donko, Agnes, Leto, Thomas L., Gao, Qiang, Shen, Binghui

“…Mice deficient in glutathione peroxidase (GPx)-1 and -2 (GPx1-/-GPx2-/- double knockout or DKO mice) develop very-early-onset (VEO) ileocolitis, suggesting…”
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Peroxidasin-mediated crosslinking of collagen IV is independent of NADPH oxidases by Sirokmány, Gábor, Kovács, Hajnal A., Lázár, Enikő, Kónya, Krisztina, Donkó, Ágnes, Enyedi, Balázs, Grasberger, Helmut, Geiszt, Miklós

“…Collagen IV is a major component of the basement membrane in epithelial tissues. The NC1 domains of collagen IV protomers are covalently linked together…”
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ZBP-89 Regulates Expression of Tryptophan Hydroxylase I and Mucosal Defense Against Salmonella Typhimurium in Mice by Essien, Bryan E, Grasberger, Helmut, Romain, Rachael D, Law, David J, Veniaminova, Natalia A, Saqui–Salces, Milena, El–Zaatari, Mohamad, Tessier, Arthur, Hayes, Michael M, Yang, Alexander C, Merchant, Juanita L

“…Background & Aims ZBP-89 (also ZNF148 or Zfp148) is a butyrate-inducible zinc finger transcription factor that binds to GC-rich DNA elements. Deletion of the…”
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P229: Non-coding variants create an enhancer cluster that causes resistance to thyrotropin via long-range interactions with a microRNA promoter by Swanson, Elliott, Grasberger, Helmut, Dumitrescu, Alexandra, Liao, Xiao-Hui, Weiss, Roy, Srichomkwun, Panudda, Pappa, Theodora, Cheng, Junfeng, Yoshimura, Takashi, Hoffmann, Phillip, França, Monica Malheiros, Tagett, Rebecca, Onigata, Kazumichi, Costagliola, Sabine, Ranchalis, Jane, Neph, Shane, Vollger, Mitchell, Chong, Jessica, Bamshad, Michael, Smits, Guillaume, Vassart, Gilbert, Refetoff, Samuel, Stergachis, Andrew

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Defects of thyroidal hydrogen peroxide generation in congenital hypothyroidism by Grasberger, Helmut

“…Thyroperoxidase-catalyzed iodination of thyroglobulin and subsequent oxidative coupling of iodinated tyrosyl residues to protein-bound iodothyronines are the…”
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Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent by Grasberger, Helmut, Refetoff, Samuel

“…Dual oxidase 2 (DUOX2), an NADPH:O(2) oxidoreductase flavoprotein, is a component of the thyroid H(2)O(2) generator crucial for hormone synthesis at the apical…”
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Identification of the Maturation Factor for Dual Oxidase by Grasberger, Helmut, Refetoff, Samuel

“…Dual oxidase 2 (DUOX2), an NADPH:O2 oxidoreductase flavoprotein, is a component of the thyroid H2O2 generator crucial for hormone synthesis at the apical…”
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Repulsive Separation of the Cytoplasmic Ends of Transmembrane Helices 3 and 6 Is Linked to Receptor Activation in a Novel Thyrotropin Receptor Mutant (M626I) by Ringkananont, Usanee, Van Durme, Joost, Montanelli, Lucia, Ugrasbul, Figen, Yu, Y. Miles, Weiss, Roy E, Refetoff, Samuel, Grasberger, Helmut

“…Ligand-dependent activation of G protein-coupled receptors (GPCRs) involves repositioning of the juxtacytoplasmic ends of transmembrane helices TM3 and TM6…”
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