Search Results - "Gras Colomer, Elena"

Relationship Between Glucocerebrosidase Activity and Clinical Response to Enzyme Replacement Therapy in Patients With Gaucher Disease Type I by Gras‐Colomer, Elena, Martínez‐Gómez, María‐Amparo, Climente‐Martí, Mónica, Fernandez‐Zarzoso, Miguel, Almela‐Tejedo, Mercedes, Giner‐Galvañ, Vicente, Marcos‐Rodríguez, Jose‐Antonio, Rodríguez‐Fernández, Alicia, Torralba‐Cabeza, Miguel‐Ángel, Merino‐Sanjuan, Matilde

“…The quantification of enzyme activity in the patient treated with enzyme replacement therapy (ERT) has been suggested as a tool for dosage individualization,…”
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Quantitative assessment of the exposure–efficacy relationship of glucocerebrosidase using Markovian elements in Gaucher patients treated with enzyme replacement therapy by Gras‐Colomer, Elena, Mangas‐Sanjuán, Víctor, Martínez‐Gómez, María‐Amparo, Climente‐Martí, Mónica, Merino‐Sanjuan, Matilde

“…Aims The aims of this study are (i) to develop a population pharmacokinetic model of enzyme activity in Gaucher‐type 1 (GD1) patients after intravenous…”
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Omics-Based Approaches for the Characterization of Pompe Disease Metabolic Phenotypes by Gómez-Cebrián, Nuria, Gras-Colomer, Elena, Poveda Andrés, José Luis, Pineda-Lucena, Antonio, Puchades-Carrasco, Leonor

“…Lysosomal storage disorders (LSDs) constitute a large group of rare, multisystemic, inherited disorders of metabolism, characterized by defects in lysosomal…”
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Impact of Pharmacokinetic and Pharmacodynamic Properties of Monoclonal Antibodies in the Management of Psoriasis by Rodríguez-Fernández, Karine, Mangas-Sanjuán, Víctor, Merino-Sanjuán, Matilde, Martorell-Calatayud, Antonio, Mateu-Puchades, Almudena, Climente-Martí, Mónica, Gras-Colomer, Elena

“…The treatment of psoriasis has been revolutionized by the emergence of biological therapies. Monoclonal antibodies (mAb) generally have complex pharmacokinetic…”
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Model-Informed Precision Dosing for Personalized Ustekinumab Treatment in Plaque Psoriasis by Rodríguez-Fernández, Karine, Zarzoso-Foj, Javier, Saez-Bello, Marina, Mateu-Puchades, Almudena, Martorell-Calatayud, Antonio, Merino-Sanjuan, Matilde, Gras-Colomer, Elena, Climente-Martí, Monica, Mangas-Sanjuan, Victor

“…Implementing model-informed precision dosing (MIPD) strategies guided by population pharmacokinetic/pharmacodynamic (PK/PD) models could enhance the management…”
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Physicochemical stability of binary admixtures of paracetamol and dexketoprofen-trometamol for patient-controlled analgesia use by López Navarro, Alfonso Ángel, Martínez Gómez, María Amparo, Gras Colomer, Elena, Campillos, Pilar, Climente Martí, Mónica

“…BackgroundIntravenous admixtures of dexketoprofen-trometamol and paracetamol are frequently used in clinical practice due to synergism obtained administering…”
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Activation and disease control of patients on chronic hemodialysis: An observational study by Ramírez-Sánchez, Sara, Soriano-Munuera, María Jesús, Gras-Colomer, Elena Lucia, Cana-Poyatos, Alicia, García-Martínez, Teresa, Ortiz-Ramon, Rafael, Linares-Aguayo, Sara, García-Testal, Alicia

“…Patient activation is a concept that refers to the willingness to manage one's health and medical care. To assess it, a patient activation measure (PAM) has…”
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Activación y control de enfermedad de pacientes en tratamiento crónico con hemodiálisis: un estudio observacional by Ramírez-Sánchez, Sara, Soriano-Munuera, María Jesús, Gras-Colomer, Elena Lucía, Cana-Poyatos, Alicia, García-Martínez, Teresa, Ortiz-Ramón, Rafael, Linares-Aguayo, Sara, García-Testal, Alicia

“…La activación del paciente es un concepto que se refiere a la voluntad de gestionar su salud y atención médica. Para evaluarla, se ha desarrollado y validado…”
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Pharmacometric characterization of entero-hepatic circulation processes of orally administered formulations of amiodarone under complex binding kinetics by Rodríguez-Fernández, Karine, Gras-Colomer, Elena, Climente-Martí, Mónica, Mangas-Sanjuán, Victor, Merino-Sanjuán, Matilde

“…•Supramicellar concentrations of AM enhanced AM absorption.•The contribution of entero-hepatic recirculation of AM has been characterized in rats.•A negligible…”
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Population pharmacokinetic of enzymatic activity of glucocerebrosidase in Gaucher disease patients treated with enzyme replacement therapy by Gras-Colomer, Elena, Mangas-Sanjuán, Víctor, Climente-Martí, Mónica, Merino-Sanjuan, Matilde

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Identification of patient-reported outcomes measures (PROMs) and patient-reported experiences measures (PREMs) in Gaucher disease in Spain by Giraldo, Pilar, Camprodón, María, Alcolea, Paloma Cerro, Gras-Colomer, Elena, Ibarretxe, Daiana, Lakhwani, Sunil, Mora, Elvira, Calderón, María Purificación Velasco, Morales-Conejo, Montserrat

“…Patient-reported outcome measures (PROMs) and patient-reported experiences measures (PREMs) are crucial for understanding the impact of GD on quality of life…”
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Value contribution of olipudase alfa therapy for the treatment of non-central nervous system manifestations of acid sphingomyelinase deficiency (ASMD) by Multi-Criteria Decision Analysis (MCDA) by Villarrubia, Jesus, Colomer, Elena Lucia Gras, Baret, Mateo

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Consensus on the criteria needed for creating a rare-disease patient registry. A Delphi study by Cavero-Carbonell, Clara, Gras-Colomer, Elena, Guaita-Calatrava, Rosana, López-Briones, Carmen, Amorós, Rubén, Abaitua, Ignacio, Posada, Manuel, Zurriaga, Oscar

“…Patient registries (PRs) are important tools for public-health surveillance and rare-disease research. The purpose of this study is to identify the most…”
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Cellular Uptake of Glucocerebrosidase in Gaucher Patients Receiving Enzyme Replacement Treatment by Gras-Colomer, Elena, Martínez-Gómez, María Amparo, Moya-Gil, Ana, Fernandez-Zarzoso, Miguel, Merino-Sanjuan, Matilde, Climente-Martí, Mónica

“…Background Enzyme replacement therapy (ERT) is currently the standard treatment for patients with Gaucher disease type I (GD1), but the pharmacokinetics have…”
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