Search Results - "Granzow, Michaela"

Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells by Trebicka, Jonel, Hennenberg, Martin, Odenthal, Margarete, Shir, Khanwali, Klein, Sabine, Granzow, Michaela, Vogt, Annabelle, Dienes, Hans-Peter, Lammert, Frank, Reichen, Jürg, Heller, Jörg, Sauerbruch, Tilman

“…Background & Aims Activation of hepatic stellate cells (HSC) and transdifferentiation to myofibroblasts following liver injury is the main culprit for hepatic…”
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Activation of the Mas Receptor by Angiotensin-(1–7) in the Renin–Angiotensin System Mediates Mesenteric Vasodilatation in Cirrhosis by Grace, Josephine A, Klein, Sabine, Herath, Chandana B, Granzow, Michaela, Schierwagen, Robert, Masing, Noemi, Walther, Thomas, Sauerbruch, Tilman, Burrell, Louise M, Angus, Peter W, Trebicka, Jonel

“…Background & Aims Splanchnic vascular hypocontractility with subsequent increased portal venous inflow leads to portal hypertension. Although the…”
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Angiotensin‐II type 1 receptor‐mediated Janus kinase 2 activation induces liver fibrosis by Granzow, Michaela, Schierwagen, Robert, Klein, Sabine, Kowallick, Benita, Huss, Sebastian, Linhart, Markus, Mazar, Irela G. Reza, Görtzen, Jan, Vogt, Annabelle, Schildberg, Frank A., Gonzalez‐Carmona, Maria A., Wojtalla, Alexandra, Krämer, Benjamin, Nattermann, Jacob, Siegmund, Sören V., Werner, Nikos, Fürst, Dieter O., Laleman, Wim, Knolle, Percy, Shah, Vijay H., Sauerbruch, Tilman, Trebicka, Jonel

“…Activation of the renin angiotensin system resulting in stimulation of angiotensin‐II (AngII) type I receptor (AT1R) is an important factor in the development…”
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HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects by Klein, Sabine, Van Beuge, Marike Marjolijn, Granzow, Michaela, Beljaars, Leonie, Schierwagen, Robert, Kilic, Sibel, Heidari, Iren, Huss, Sebastian, Sauerbruch, Tilman, Poelstra, Klaas, Trebicka, Jonel

“…Background & Aims Rho-kinase activation mediates cell contraction and increases intrahepatic resistance and consequently portal pressure in liver cirrhosis…”
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Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats by Klein, Sabine, Klösel, Jeremias, Schierwagen, Robert, Körner, Christian, Granzow, Michaela, Huss, Sebastian, Mazar, Irela Gretchen Reza, Weber, Susanne, van den Ven, Peter F M, Pieper-Fürst, Ursula, Fürst, Dieter O, Nattermann, Jacob, Lammert, Frank, Sauerbruch, Tilman, Trebicka, Jonel

“…Hepatic myofibroblasts (MFB) show increased proliferation, migration and collagen production, which are crucial for hepatic fibrogenesis. Atorvastatin…”
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Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB2 receptor-deficient mice and decreased in CB1 receptor knockouts by Trebicka, Jonel, Racz, Ildiko, Siegmund, Sören V., Cara, Erlind, Granzow, Michaela, Schierwagen, Robert, Klein, Sabine, Wojtalla, Alexandra, Hennenberg, Martin, Huss, Sebastian, Fischer, Hans-Peter, Heller, Jörg, Zimmer, Andreas, Sauerbruch, Tilman

“…Background: Alcohol is a common cause of hepatic liver injury with steatosis and fibrosis. Cannabinoid receptors (CB) modulate steatosis, inflammation and…”
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Serum markers of the extracellular matrix remodeling reflect antifibrotic therapy in bile-duct ligated rats by Schierwagen, Robert, Leeming, Diana J, Klein, Sabine, Granzow, Michaela, Nielsen, Mette J, Sauerbruch, Tilman, Krag, Aleksander, Karsdal, Morten A, Trebicka, Jonel

“…Progression of liver fibrosis is characterized by synthesis and degradation of extracellular matrix (ECM). Matrix-metalloproteinases (MMP) cleave collagen…”
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Statins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension by Uschner, Frank E., Ranabhat, Ganesh, Choi, Steve S., Granzow, Michaela, Klein, Sabine, Schierwagen, Robert, Raskopf, Esther, Gautsch, Sebastian, van der Ven, Peter F. M., Fürst, Dieter O., Strassburg, Christian P., Sauerbruch, Tilman, Mae Diehl, Anna, Trebicka, Jonel

“…Liver cirrhosis but also portal vein obstruction cause portal hypertension (PHT) and angiogenesis. This study investigated the differences of angiogenesis in…”
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TGR(mREN2)27 rats develop non-alcoholic fatty liver disease-associated portal hypertension responsive to modulations of Janus-kinase 2 and Mas receptor by Klein, Sabine, Kleine, Carola-Ellen, Pieper, Andrea, Granzow, Michaela, Gautsch, Sebastian, Himmit, Mimoun, Kahrmann, Katharina, Schierwagen, Robert, Uschner, Frank Erhard, Magdaleno, Fernando, Naoum, Maria Eleni, Kristiansen, Glen, Walther, Thomas, Bader, Michael, Sauerbruch, Tilman, Trebicka, Jonel

“…Prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing. Resulting fibrosis and portal hypertension, as a possible secondary event, may…”
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Role of β3‐adrenoceptors for intrahepatic resistance and portal hypertension in liver cirrhosis by Trebicka, Jonel, Hennenberg, Martin, Schulze Pröbsting, Andrea, Laleman, Wim, Klein, Sabine, Granzow, Michaela, Nevens, Frederik, Zaagsma, Johan, Heller, Jörg, Sauerbruch, Tilman

“…Increased intrahepatic resistance and splanchnic blood flow cause portal hypertension in liver cirrhosis. Nonselective β‐adrenoceptor (β‐AR) antagonists have…”
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The Archaeal Lsm Protein Binds to Small RNAs by Fischer, Susan, Benz, Juliane, Späth, Bettina, Maier, Lisa-Katharina, Straub, Julia, Granzow, Michaela, Raabe, Monika, Urlaub, Henning, Hoffmann, Jan, Brutschy, Bernd, Allers, Thorsten, Soppa, Jörg, Marchfelder, Anita

“…Proteins of the Lsm family, including eukaryotic Sm proteins and bacterial Hfq, are key players in RNA metabolism. Little is known about the archaeal…”
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Hepatic and HSC-specific sorafenib effects in rats with established secondary biliary cirrhosis by Hennenberg, Martin, Trebicka, Jonel, Kohistani, Zaki, Stark, Christian, Nischalke, Hans-Dieter, Krämer, Benjamin, Körner, Christian, Klein, Sabine, Granzow, Michaela, Fischer, Hans-Peter, Heller, Jörg, Sauerbruch, Tilman

“…Portal hypertension in cirrhosis depends on increased intrahepatic vascular resistance, which is explained by fibrosis and intrahepatic hyperresponsiveness to…”
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The endocannabinoid N-arachidonoyl dopamine (NADA) selectively induces oxidative stress-mediated cell death in hepatic stellate cells but not in hepatocytes by Wojtalla, Alexandra, Herweck, Frank, Granzow, Michaela, Klein, Sabine, Trebicka, Jonel, Huss, Sebastian, Lerner, Raissa, Lutz, Beat, Schildberg, Frank Alexander, Knolle, Percy Alexander, Sauerbruch, Tilman, Singer, Manfred Vincenz, Zimmer, Andreas, Siegmund, Sören Volker

“…The endocannabinoid system is a crucial regulator of hepatic fibrogenesis. We have previously shown that the endocannabinoid anandamide (AEA) is a lipid…”
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Small RNAs of the halophilic archaeon Haloferax volcanii by Soppa, Jörg, Straub, Julia, Brenneis, Mariam, Jellen-Ritter, Angelika, Heyer, Ruth, Fischer, Susan, Granzow, Michaela, Voss, Björn, Hess, Wolfgang R, Tjaden, Brian, Marchfelder, Anita

“…In recent years, sRNAs (small non-coding RNAs) have been found to be abundant in eukaryotes and bacteria and have been recognized as a novel class of gene…”
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Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB2 receptor-deficient mice and decreased in CB1 receptor knockouts: Cannabinoid receptor and alcohol in mice by Trebicka, Jonel, Racz, Ildiko, Siegmund, Sören V., Cara, Erlind, Granzow, Michaela, Schierwagen, Robert, Klein, Sabine, Wojtalla, Alexandra, Hennenberg, Martin, Huss, Sebastian, Fischer, Hans-Peter, Heller, Jörg, Zimmer, Andreas, Sauerbruch, Tilman

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Role of beta3-adrenoceptors for intrahepatic resistance and portal hypertension in liver cirrhosis by Trebicka, Jonel, Hennenberg, Martin, Schulze Pröbsting, Andrea, Laleman, Wim, Klein, Sabine, Granzow, Michaela, Nevens, Frederik, Zaagsma, Johan, Heller, Jörg, Sauerbruch, Tilman

“…Increased intrahepatic resistance and splanchnic blood flow cause portal hypertension in liver cirrhosis. Nonselective beta-adrenoceptor (beta-AR) antagonists…”
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