Search Results - "Granum, Stine"

A novel SARS-CoV-2 Beta RBD DNA vaccine directly targeted to antigen-presenting cells induces strong humoral and T cell responses by Kuczkowska, Katarzyna, Bjerkan, Louise, Stubsrud, Elisabeth, Husbyn, Hannah Cuthbertson, Chellappa, Stalin, Hauge, Anette, Skarshaug, Renate, Torgersen, Maria Lyngaas, Heim, Joel Benjamin, Jørgensen, Marthe Jøntvedt, Wold, Christian Winther, Schleimann, Mariane Høgsbjerg, Tolstrup, Martin, Granum, Stine, Fredriksen, Agnete Brunsvik, Pedersen, Mikkel Wandahl, Norheim, Gunnstein

“…Throughout the COVID-19 pandemic, several variants of concern (VoC) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have evolved, affecting…”
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SH2D2A modulates T cell mediated protection to a B cell derived tumor in transgenic mice by Berge, Tone, Grønningsæter, Ingrid Helene Bø, Lorvik, Kristina Berg, Abrahamsen, Greger, Granum, Stine, Sundvold-Gjerstad, Vibeke, Corthay, Alexandre, Bogen, Bjarne, Spurkland, Anne

“…T cell specific adapter protein (TSAd), encoded by the SH2D2A gene, modulates signaling downstream of the T cell receptor (TCR). Young, unchallenged…”
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T cell specific adapter protein (TSAd) interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells by Berge, Tone, Sundvold-Gjerstad, Vibeke, Granum, Stine, Andersen, Thorny C B, Holthe, Gunn B, Claesson-Welsh, Lena, Andreotti, Amy H, Inngjerdingen, Marit, Spurkland, Anne

“…The chemokine CXCL12/SDF-1alpha interacts with its G-protein coupled receptor CXCR4 to induce migration of lymphoid and endothelial cells. T cell specific…”
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Modulation of Lck Function through Multisite Docking to T Cell-specific Adapter Protein by Granum, Stine, Andersen, Thorny Cesilie Bie, Sørlie, Morten, Jørgensen, Marit, Koll, Lise, Berge, Tone, Lea, Tor, Fleckenstein, Burkhard, Spurkland, Anne, Sundvold-Gjerstad, Vibeke

“…T cell-specific adapter protein (TSAd), encoded by the SH2D2A gene, interacts with Lck through its C terminus and thus modulates Lck activity. Here we mapped…”
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Structure function analysis of SH2D2A isoforms expressed in T cells reveals a crucial role for the proline rich region encoded by SH2D2A exon 7 by Granum, Stine, Sundvold-Gjerstad, Vibeke, Dai, Ke-Zheng, Kolltveit, Kristin Melkevik, Hildebrand, Kjersti, Huitfeldt, Henrik S, Lea, Tor, Spurkland, Anne

“…The activation induced T cell specific adapter protein (TSAd), encoded by SH2D2A, interacts with and modulates Lck activity. Several transcript variants of…”
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Interaction of T‐cell‐specific adapter protein with Src‐ and Tec‐family kinases by Huszenicza, Zsuzsa, Gilmour, Brian C., Koll, Lise, Kjelstrup, Hanna, Chan, Hanna, Sundvold, Vibeke, Granum, Stine, Spurkland, Anne

“…Adapter proteins are flexible and dynamic modulators of cellular signalling that are important for immune cell function. One of these, the T‐cell‐specific…”
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Antigen presenting cell targeted T cell DNA vaccine inducing strong and specific cellular responses across multiple T cell epitopes of SARS-COV-2 by Norheim, Gunnstein, Kuczkowska, Katarzyna, Stubsrud, Elisabeth, Bjerkan, Louise, Jørgensen, Marthe, Husbyn, Hannah, Bøthun, Anne, Dürkoop, Mirjam, Sekelja, Monika, Namouchi, Amine, Lindahl, Torbjørn, Granum, Stine, Chellappa, Stalin, Skarshaug, Renate, Klinger, Mark, Ebert, Peter, Osborne, Edward, Fredriksen, Agnete Brunsvik, Pedersen, Mikkel Wandahl

“…Abstract The severe respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19 has continuously evolved with successive new virus variants of concern…”
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Abstract 5003: Vaccibody DNA vaccine platform VB10.NEO induces strong neo-antigen specific CD8+ T cell responses critical to cure established tumors in pre-clinical models by Stubsrud, Elisabeth, Granum, Stine, Zell-Flagstad, Helene, Bersaas, Audun, Skullerud, Lise Madelene, Sekelja, Monika, Schjetne, Karoline, Fredriksen, Agnete

“…Abstract BACKGROUND: Recent advances in the field of cancer immunotherapy have identified CD8+ T cell responses against tumor-specific neoantigens as a key…”
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Abstract 2256: Combination of neoantigen DNA plasmid vaccine VB10.NEO and NKTR-214, a CD122-biased immunostimulatory cytokine, induces strong neoantigen-specific T cell responses and sustained tumor regression in pre-clinical models by Granum, Stine, Zell-Flagstad, Helene, Bersaas, Audun, Skullerud, Lise, Müller, Elisabeth, Axelsen, Mads, Schjetne, Karoline, Zalevsky, Jonathan, Fredriksen, Agnete

“…Abstract BACKGROUND: VB10.NEO is a highly potent DNA plasmid vaccine with intrinsic adjuvant effect designed for efficient delivery of personalized neoepitopes…”
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The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192 by Granum, Stine, Sundvold-Gjerstad, Vibeke, Gopalakrishnan, Ramakrishna Prabhu, Berge, Tone, Koll, Lise, Abrahamsen, Greger, Sørlie, Morten, Spurkland, Anne

“…The substrate specificity of Src family kinases (SFKs) is partly determined by their Src homology 2 (SH2) domains. Thus, transient alterations in the SH2…”
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Abstract 6752: Targeting of neoantigen cancer vaccines to antigen presenting cells results in faster and broader T cell responses whether encoded in DNA or mRNA by Weinert, Brian T., Skullerud, Lise, Solbakken, Eirik, Textor, Ana, Dürkoop, Mirjam, Winge, Inga Patrycja, Norheim, Gunnstein, Stubsrud, Elisabeth, Granum, Stine, Pedersen, Mikkel W., Norell, Håkan

“…Abstract Individualized cancer vaccines based on patient-specific neoantigens represent a groundbreaking approach in oncology, offering a highly individualized…”
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The SH3 domains of the protein kinases ITK and LCK compete for adjacent sites on T cell–specific adapter protein by Andersen, Thorny Cesilie Bie, Kristiansen, Per Eugen, Huszenicza, Zsuzsa, Johansson, Maria U., Gopalakrishnan, Ramakrishna Prabhu, Kjelstrup, Hanna, Boyken, Scott, Sundvold-Gjerstad, Vibeke, Granum, Stine, Sørli, Morten, Backe, Paul Hoff, Fulton, D. Bruce, Karlsson, B. Göran, Andreotti, Amy H., Spurkland, Anne

“…T-cell activation requires stimulation of specific intracellular signaling pathways in which protein-tyrosine kinases, phosphatases, and adapter proteins…”
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Abstract 3558: A novel and versatile cytokine empowered DNA vaccine platform with superior immune activating potential by Beraas, Audun, Dillard, Pierre, Wong, Judith Jing, Wold, Christian Winther, Solbakken, Eirik, Oslen, Linn Guro, Heim, Joel Benjamin, Chellappa, Stalin, Fredriksen, Agnete, Pedersen, Mikkel Wandahl, Granum, Stine

“…Abstract Immunotherapy, in particular Immune Checkpoint Blockade (ICB) has been regarded as the next standard of care for many solid tumor indications. Yet, a…”
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T cell specific adaptor protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells by Hem, Cecilie Dahl, Sundvold-Gjerstad, Vibeke, Granum, Stine, Koll, Lise, Abrahamsen, Greger, Buday, Laszlo, Spurkland, Anne

“…The Lck and Src binding adaptor protein TSAd (T cell specific adaptor) regulates actin polymerization in T cells and endothelial cells. The molecular details…”
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T Cell Specific Adapter Protein by Berge, Tone, Sundvold-Gjerstad, Vibeke, Granum, Stine, Andersen, Thorny C. B, Holthe, Gunn B, Claesson-Welsh, Lena, Andreotti, Amy H, Inngjerdingen, Marit, Spurkland, Anne

“…Background The chemokine CXCL12/SDF-1[alpha] interacts with its G-protein coupled receptor CXCR4 to induce migration of lymphoid and endothelial cells. T cell…”
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Expression of the T-cell-specific adapter protein in oral epithelium by Kolltveit, Kristin M., Schreurs, Olav, Østrem, Janet, Søland, Tine M., Khuu, Cuong, Berge, Tone, Messelt, Edward, Hayashi, Katsuhiko, Granum, Stine, Spurkland, Anne, Schenck, Karl

“…Kolltveit KM, Schreurs O, Østrem J, Søland TM, Khuu C, Berge T, Messelt E, Hayashi K, Granum S, Spurkland A, Schenck K. Expression of the T‐cell‐specific…”
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Expression of SH2D2A in T-cells is regulated both at the transcriptional and translational level by Kolltveit, Kristin Melkevik, Granum, Stine, Aasheim, Hans-Christian, Forsbring, Monika, Sundvold-Gjerstad, Vibeke, Dai, Ke-Zheng, Molberg, Øyvind, Schjetne, Karoline W., Bogen, Bjarne, Shapiro, Virginia S., Johansen, Finn-Eirik, Schenck, Karl, Spurkland, Anne

“…The T-cell specific adapter protein (TSAd) encoded by the SH2D2A gene is up-regulated in activated human CD4+ T-cells in a cAMP-dependent manner. Expression of…”
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The C terminus of T cell‐specific adapter protein (TSAd) is necessary for TSAd‐mediated inhibition of Lck activity by Sundvold‐Gjerstad, Vibeke, Granum, Stine, Mustelin, Tomas, Andersen, Thorny C. B., Berge, Tone, Shapiro, Michael J., Shapiro, Virginia S., Spurkland, Anne, Lea, Tor

“…T cell‐specific adapter protein (TSAd), encoded by the SH2D2A gene, is expressed in activated T cells. The function of TSAd is as yet unknown. We previously…”
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