Search Results - "Grantham, Hugh"

Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways by Majd, Shohreh, Power, John H, Grantham, Hugh J M

“…Accumulation of protein aggregates is the leading cause of cellular dysfunction in neurodegenerative disorders. Alzheimer's disease (AD), Parkinson's disease…”
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Early glycogen synthase kinase-3β and protein phosphatase 2A independent tau dephosphorylation during global brain ischaemia and reperfusion following cardiac arrest and the role of the adenosine monophosphate kinase pathway by Majd, Shohreh, Power, John H. T., Koblar, Simon A., Grantham, Hugh J. M.

“…Abnormal tau phosphorylation (p‐tau) has been shown after hypoxic damage to the brain associated with traumatic brain injury and stroke. As the level of p‐tau…”
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Regional variation in the characteristics, incidence and outcomes of out-of-hospital cardiac arrest in Australia and New Zealand: Results from the Aus-ROC Epistry by Beck, Ben, Bray, Janet, Cameron, Peter, Smith, Karen, Walker, Tony, Grantham, Hugh, Hein, Cindy, Thorrowgood, Melanie, Smith, Anthony, Inoue, Madoka, Smith, Tony, Dicker, Bridget, Swain, Andy, Bosley, Emma, Pemberton, Katherine, McKay, Michael, Johnston-Leek, Malcolm, Perkins, Gavin D., Nichol, Graham, Finn, Judith

“…The aim of this study was to investigate regional variation in the characteristics, incidence and outcomes of out-of-hospital cardiac arrest (OHCA) in…”
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The epidemiology of out-of-hospital cardiac arrest in Australia and New Zealand: A binational report from the Australasian Resuscitation Outcomes Consortium (Aus-ROC) by Bray, Janet, Howell, Stuart, Ball, Stephen, Doan, Tan, Bosley, Emma, Smith, Karen, Dicker, Bridget, Faddy, Steven, Thorrowgood, Melanie, Swain, Andy, Thomas, Andrew, Wilson, Alexander, Shipp, Carol, Walker, Tony, Bailey, Paul, Finn, Judith, Smith, Tony, Bernard, Stephen, Grantham, Hugh, Norsworthy, Damien, Wren, Howard, Driscoll, Keith, McDermott, Mike, Ranjan, Abhishek, Larsen, Richard, Perillo, Samuel, Georgakas, Con, Waters, Jeff, Cameron, Peter, Nichol, Graham, Perkins, Gavin

“…The Australasian Resuscitation Outcomes Consortium (Aus-ROC) out-of-hospital cardiac arrest (OHCA) Epistry (Epidemiological Registry) now covers 100% of…”
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Care of the patient with invasive meningococcal disease by prehospital emergency medical service clinicians: a scoping review by Pearce, James, Peters, Micah, May, Nikki, Marshall, Helen, Hein, Cindy, Grantham, Hugh

“…ObjectiveThe objective of this scoping review is to systematically map the literature to identify the scope, depth, key concepts and gaps in the evidence…”
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Student & tutor consensus: a partnership in assessment for learning by Thompson, James, Houston, Don, Dansie, Kathryn, Rayner, Timothy, Pointon, Timothy, Pope, Simon, Cayetano, Anthea, Mitchell, Brad, Grantham, Hugh

“…The mistakes made when attempting tasks often prove to be some of the most invaluable learning experiences. Despite this, outcome and results driven assessment…”
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Establishing the Aus-ROC Australian and New Zealand out-of-hospital cardiac arrest Epistry by Beck, Ben, Bray, Janet, Smith, Karen, Walker, Tony, Grantham, Hugh, Hein, Cindy, Thorrowgood, Melanie, Smith, Anthony, Smith, Tony, Dicker, Bridget, Swain, Andy, Bailey, Mark, Bosley, Emma, Pemberton, Katherine, Cameron, Peter, Nichol, Graham, Finn, Judith

“…IntroductionOut-of-hospital cardiac arrest (OHCA) is a global health problem with low survival. Regional variation in survival has heightened interest in…”
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A comparison of LKB1/AMPK/mTOR metabolic axis response to global ischaemia in brain, heart, liver and kidney in a rat model of cardiac arrest by Majd, Shohreh, Power, John H T, Chataway, Timothy K, Grantham, Hugh J M

“…Cellular energy failure in high metabolic rate organs is one of the underlying causes for many disorders such as neurodegenerative diseases, cardiomyopathies,…”
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Design of the RINSE trial: the rapid infusion of cold normal saline by paramedics during CPR by Deasy, Conor, Bernard, Stephen, Cameron, Peter, Jacobs, Ian, Smith, Karen, Hein, Cindy, Grantham, Hugh, Finn, Judith

“…The International Liaison Committee on Resuscitation (ILCOR) now recommends therapeutic hypothermia (TH) (33 °C for 12-24 hours) as soon as possible for…”
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Resuscitation update for general practitioners by Grantham Asm, Hugh, Christiansen, Rowena

“…Background: The latest changes to resuscitation guidelines in Australia were released in 2016. Few of the changes will have an impact on general practitioners…”
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Team Echo: Observations and Lessons Learned in the Recovery Phase of the 2004 Asian Tsunami by Bridgewater, Franklin H.G., Aspinall, Edward T., Booth, Joy P.M., Capps, Roger A., Grantham, Hugh J.M., Pearce, Andrew P., Ritchie, Brett K.

“…The 26 December 2004 Tsunami resulted in a death toll of >270,000 persons, making it the most lethal tsunami in recorded history. This article presents…”
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Review article: Improving the hospital clinical handover between paramedics and emergency department staff in the deteriorating patient by Dawson, Sarah, King, Lindy, Grantham, Hugh

“…Clinical communication and recognising and responding to a deteriorating patient are key current patient safety issues in healthcare. The aim of this…”
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Opinions of Nurses and Physicians on a Patient, Family, and Visitor Activated Rapid Response System in Use Across Two Hospital Settings by King, Lindy, Minyaev, Stanislav, Grantham, Hugh, Clark, Robyn A.

“…Early detection of deterioration of hospitalized patients with timely intervention improves outcomes in the hospital. Patients, family members, and visitors…”
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Effect of Lower vs Higher Oxygen Saturation Targets on Survival to Hospital Discharge Among Patients Resuscitated After Out-of-Hospital Cardiac Arrest: The EXACT Randomized Clinical Trial by Bernard, Stephen A, Bray, Janet E, Smith, Karen, Stephenson, Michael, Finn, Judith, Grantham, Hugh, Hein, Cindy, Masters, Stacey, Stub, Dion, Perkins, Gavin D, Dodge, Natasha, Martin, Catherine, Hopkins, Sarah, Cameron, Peter

“…IMPORTANCE: The administration of a high fraction of oxygen following return of spontaneous circulation in out-of-hospital cardiac arrest may increase…”
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Induction of Therapeutic Hypothermia During Out-of-Hospital Cardiac Arrest Using a Rapid Infusion of Cold Saline: The RINSE Trial (Rapid Infusion of Cold Normal Saline) by Bernard, Stephen A, Smith, Karen, Finn, Judith, Hein, Cindy, Grantham, Hugh, Bray, Janet E, Deasy, Conor, Stephenson, Michael, Williams, Teresa A, Straney, Lahn D, Brink, Deon, Larsen, Richard, Cotton, Chris, Cameron, Peter

“…BACKGROUND:Patients successfully resuscitated by paramedics from out-of-hospital cardiac arrest often have severe neurologic injury. Laboratory and…”
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Oxygen titration after resuscitation from out-of-hospital cardiac arrest: A multi-centre, randomised controlled pilot study (the EXACT pilot trial) by Bray, Janet E., Hein, Cindy, Smith, Karen, Stephenson, Michael, Grantham, Hugh, Finn, Judith, Stub, Dion, Cameron, Peter, Bernard, Stephen

“…Recent studies suggest the administration of 100% oxygen to hyperoxic levels following return-of-spontaneous-circulation (ROSC) post-cardiac arrest may be…”
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Do User-Applied Safety Labels on Medication Syringes Reduce the Incidence of Medication Errors During Rapid Medical Response Intervention for Deteriorating Patients in Wards? A Systematic Search and Review by Mikhail, John, Grantham, Hugh, King, Lindy

“…INTRODUCTIONIntravenous medication errors (MEs) occur during medical emergency situations. An initiative, not yet in common practice, that could address these…”
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Global review of delay time in seeking medical care for chest pain: An integrative literature review by Wechkunanukul, Kannikar, Grantham, Hugh, Clark, Robyn A.

“…The aim of this review is to summarise research from a range of countries describing the differences in time taken to seek medical care for chest pain and…”
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Review article: Roles of activities of daily living and frailty assessments for residents of residential aged care services in emergency department transfers: A scoping review by Smyth, James, Umapathysivam, Kandiah, Hendrix, Ivanka, Grantham, Hugh, Arendts, Glenn, Visvanathan, Renuka

“…Residents from residential aged care services (RACS) (i.e. nursing homes) many of whom are frail or disabled, are frequently transferred to ED for treatment of…”
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Hospital Testing of the Effectiveness of Co-Designed Educational Materials to Improve Patient and Visitor Knowledge and Confidence in Reporting Patient Deterioration by King, Lindy, Belan, Ingrid, Clark, Robyn A, Young, Tom, Grantham, Hugh, Thornton, Karleen, Kidd, Michael R

“…Co-designed educational materials could significantly improve the likelihood of patients and visitors (consumers) escalating care through hospital systems. The…”
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