Search Results - "Grant, Timothy"

Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6 by Grant, Timothy, Grigorieff, Nikolaus

“…Biological specimens suffer radiation damage when imaged in an electron microscope, ultimately limiting the attainable resolution. At a given resolution, an…”
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cisTEM, user-friendly software for single-particle image processing by Grant, Timothy, Rohou, Alexis, Grigorieff, Nikolaus

“…We have developed new open-source software called cisTEM (computational imaging system for transmission electron microscopy) for the processing of data for…”
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Automatic estimation and correction of anisotropic magnification distortion in electron microscopes by Grant, Timothy, Grigorieff, Nikolaus

“…We demonstrate a significant anisotropic magnification distortion, found on an FEI Titan Krios microscope and affecting magnifications commonly used for data…”
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Activation of NMDA receptors and the mechanism of inhibition by ifenprodil by Tajima, Nami, Karakas, Erkan, Grant, Timothy, Simorowski, Noriko, Diaz-Avalos, Ruben, Grigorieff, Nikolaus, Furukawa, Hiro

“…The physiology of N -methyl- d -aspartate (NMDA) receptors is fundamental to brain development and function. NMDA receptors are ionotropic glutamate receptors…”
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The legal determinants of health: harnessing the power of law for global health and sustainable development by Gostin, Lawrence O, Monahan, John T, Kaldor, Jenny, DeBartolo, Mary, Friedman, Eric A, Gottschalk, Katie, Kim, Susan C, Alwan, Ala, Binagwaho, Agnes, Burci, Gian Luca, Cabal, Luisa, DeLand, Katherine, Evans, Timothy Grant, Goosby, Eric, Hossain, Sara, Koh, Howard, Ooms, Gorik, Roses Periago, Mirta, Uprimny, Rodrigo, Yamin, Alicia Ely

“…Health risks in the 21st century are beyond the control of any government in any country. In an era of globalisation, promoting public health and equity…”
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Global seroprevalence of SARS-CoV-2 antibodies: A systematic review and meta-analysis by Bobrovitz, Niklas, Arora, Rahul Krishan, Cao, Christian, Boucher, Emily, Liu, Michael, Donnici, Claire, Yanes-Lane, Mercedes, Whelan, Mairead, Perlman-Arrow, Sara, Chen, Judy, Rahim, Hannah, Ilincic, Natasha, Segal, Mitchell, Duarte, Nathan, Van Wyk, Jordan, Yan, Tingting, Atmaja, Austin, Rocco, Simona, Joseph, Abel, Penny, Lucas, Clifton, David A, Williamson, Tyler, Yansouni, Cedric P, Evans, Timothy Grant, Chevrier, Jonathan, Papenburg, Jesse, Cheng, Matthew P

“…Many studies report the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies. We aimed to synthesize seroprevalence data…”
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Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy by Liang, Bo, Li, Zongli, Jenni, Simon, Rahmeh, Amal A., Morin, Benjamin M., Grant, Timothy, Grigorieff, Nikolaus, Harrison, Stephen C., Whelan, Sean P.J.

“…The large (L) proteins of non-segmented, negative-strand RNA viruses, a group that includes Ebola and rabies viruses, catalyze RNA-dependent RNA polymerization…”
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High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations by Jung, James, Grant, Timothy, Thomas, Dennis R., Diehnelt, Chris W., Grigorieff, Nikolaus, Joshua-Tor, Leemor

“…Noroviruses are a leading cause of foodborne illnesses worldwide. Although GII.4 strains have been responsible for most norovirus outbreaks, the assembled…”
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Small LEA proteins mitigate air-water interface damage to fragile cryo-EM samples during plunge freezing by Abe, Kaitlyn M., Li, Gan, He, Qixiang, Grant, Timothy, Lim, Ci Ji

“…Air-water interface (AWI) interactions during cryo-electron microscopy (cryo-EM) sample preparation cause significant sample loss, hindering structural biology…”
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Structure and assembly of calcium homeostasis modulator proteins by Syrjanen, Johanna L., Michalski, Kevin, Chou, Tsung-Han, Grant, Timothy, Rao, Shanlin, Simorowski, Noriko, Tucker, Stephen J., Grigorieff, Nikolaus, Furukawa, Hiro

“…The biological membranes of many cell types contain large-pore channels through which a wide variety of ions and metabolites permeate. Examples include…”
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Basin-scale study of CO2 storage in stacked sequence of geological formations by Wijaya, Nur, Morgan, David, Vikara, Derek, Grant, Timothy, Cunha, Luciane, Liu, Guoxiang

“…Commercial scale decarbonization through carbon capture and storage may likely involve many CO 2 storage projects located in close proximity. The close…”
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Author Correction: Basin-scale study of CO2 storage in stacked sequence of geological formations by Wijaya, Nur, Morgan, David, Vikara, Derek, Grant, Timothy, Cunha, Luciane, Liu, Guoxiang

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Locating macromolecular assemblies in cells by 2D template matching with cisTEM by Lucas, Bronwyn A, Himes, Benjamin A, Xue, Liang, Grant, Timothy, Mahamid, Julia, Grigorieff, Nikolaus

“…For a more complete understanding of molecular mechanisms, it is important to study macromolecules and their assemblies in the broader context of the cell…”
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A Single Neonatal Exposure to BMAA in a Rat Model Produces Neuropathology Consistent with Neurodegenerative Diseases by Scott, Laura Louise, Downing, Timothy Grant

“…Although cyanobacterial β- -methylamino-l-alanine (BMAA) has been implicated in the development of Alzheimer's Disease (AD), Parkinson's Disease (PD) and…”
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Three-dimensional structure determination of protein complexes using matrix-landing mass spectrometry by Westphall, Michael S., Lee, Kenneth W., Salome, Austin Z., Lodge, Jean M., Grant, Timothy, Coon, Joshua J.

“…Native mass spectrometry (MS) is increasingly used to provide complementary data to electron microscopy (EM) for protein structure characterization. Beyond the…”
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Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome by Abeyrathne, Priyanka D, Koh, Cha San, Grant, Timothy, Grigorieff, Nikolaus, Korostelev, Andrei A

“…Internal ribosome entry sites (IRESs) mediate cap-independent translation of viral mRNAs. Using electron cryo-microscopy of a single specimen, we present five…”
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Inferences of ocean currents from seismic streamer position data by Grant, Timothy J.

“…ABSTRACT This paper describes the first attempt to infer ocean currents from the shapes of seismic streamers using real data. It demonstrates that it is…”
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Intranasal fentanyl for the management of acute pain in children by Murphy, Adrian, O'Sullivan, Ronan, Wakai, Abel, Grant, Timothy S, Barrett, Michael J, Cronin, John, McCoy, Siobhan C, Hom, Jeffrey, Kandamany, Nandini

“…Pain is the most common symptom in the emergency setting; however, timely management of acute pain in children continues to be suboptimal. Intranasal drug…”
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The vertical shape of a buoyant acoustic streamer between depth control units by Grant, Timothy J.

“…When conducting marine seismic surveys it is important to know the vertical profile of the seismic streamer. Typically the streamer has a density that is…”
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Global ecological analysis of COVID-19 mortality and comparison between “the East” and “the West” by Pablos-Méndez, Ariel, Villa, Simone, Monti, Maria Cristina, Raviglione, Mario Carlo, Tabish, Hilary Brown, Evans, Timothy Grant, Cash, Richard Alan

“…Although SARS-CoV-2 was first reported in China and neighbouring countries, the pandemic quickly spread around the globe. This paper explores national drivers…”
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