Search Results - "Grant, Seth G."

Synapse diversity and synaptome architecture in human genetic disorders by Grant, Seth G N

“…Abstract Over 130 brain diseases are caused by mutations that disrupt genes encoding the proteome of excitatory synapses. These include neurological and…”
Get full text

Synaptopathies: diseases of the synaptome by Grant, Seth GN

“…Highlights ► The protein composition of human synapses is highly complex. ► Hundreds of mutations impact on synapse proteins causing over 100 brain diseases. ►…”
Get full text

Comparative study of human and mouse postsynaptic proteomes finds high compositional conservation and abundance differences for key synaptic proteins by Bayés, Alex, Collins, Mark O, Croning, Mike D R, van de Lagemaat, Louie N, Choudhary, Jyoti S, Grant, Seth G N

“…Direct comparison of protein components from human and mouse excitatory synapses is important for determining the suitability of mice as models of human brain…”
Get full text

Computational geometry analysis of dendritic spines by structured illumination microscopy by Kashiwagi, Yutaro, Higashi, Takahito, Obashi, Kazuki, Sato, Yuka, Komiyama, Noboru H., Grant, Seth G. N., Okabe, Shigeo

“…Dendritic spines are the postsynaptic sites that receive most of the excitatory synaptic inputs, and thus provide the structural basis for synaptic function…”
Get full text

Neuroproteomics: understanding the molecular organization and complexity of the brain by Grant, Seth G. N, Bayés, Alex

“…Key Points The context and role of individual proteins in complexes, pathways and networks can be experimentally examined using neuroproteomics, thus,…”
Get full text

Excitatory to inhibitory synaptic ratios are unchanged at presymptomatic stages in multiple models of ALS by Bonthron, Calum, Burley, Sarah, Broadhead, Matthew J, Metodieva, Vanya, Grant, Seth G N, Chandran, Siddharthan, Miles, Gareth B

“…Hyperexcitability of motor neurons and spinal cord motor circuitry has been widely reported in the early stages of Amyotrophic Lateral Sclerosis (ALS). Changes…”
Get full text

Evolution of Synapse Complexity and Diversity by EMES, Richard D, GRANT, Seth G. N

“…Proteomic studies of the composition of mammalian synapses have revealed a high degree of complexity. The postsynaptic and presynaptic terminals are molecular…”
Get full text

Estimation of the number of synapses in the hippocampus and brain-wide by volume electron microscopy and genetic labeling by Santuy, Andrea, Tomás-Roca, Laura, Rodríguez, José-Rodrigo, González-Soriano, Juncal, Zhu, Fei, Qiu, Zhen, Grant, Seth G. N., DeFelipe, Javier, Merchan-Perez, Angel

“…Determining the number of synapses that are present in different brain regions is crucial to understand brain connectivity as a whole. Membrane-associated…”
Get full text

The origin and evolution of synapses by Grant, Seth G. N, Ryan, Tomás J

“…Key Points The molecular composition of the synapse has recently been proved to be useful for studying the evolution of the brain. Synapse proteomics data…”
Get full text

The synapse in traumatic brain injury by Jamjoom, Aimun A B, Rhodes, Jonathan, Andrews, Peter J D, Grant, Seth G N

“…Traumatic brain injury (TBI) is a leading cause of death and disability worldwide and is a risk factor for dementia later in life. Research into the…”
Get full text

Identification of Vulnerable Cell Types in Major Brain Disorders Using Single Cell Transcriptomes and Expression Weighted Cell Type Enrichment by Skene, Nathan G, Grant, Seth G N

“…The cell types that trigger the primary pathology in many brain diseases remain largely unknown. One route to understanding the primary pathological cell type…”
Get full text

A brainwide atlas of synapses across the mouse life span by Cizeron, Mélissa, Qiu, Zhen, Koniaris, Babis, Gokhale, Ragini, Komiyama, Noboru H, Fransén, Erik, Grant, Seth G N

“…Synapses connect neurons together to form the circuits of the brain, and their molecular composition controls innate and learned behavior. We analyzed the…”
Get full text

FAM81A is a postsynaptic protein that regulates the condensation of postsynaptic proteins via liquid-liquid phase separation by Kaizuka, Takeshi, Hirouchi, Taisei, Saneyoshi, Takeo, Shirafuji, Toshihiko, Collins, Mark O, Grant, Seth G N, Hayashi, Yasunori, Takumi, Toru

“…Proteome analyses of the postsynaptic density (PSD), a proteinaceous specialization beneath the postsynaptic membrane of excitatory synapses, have identified…”
Get full text

Association of Mouse Dlg4 (PSD-95) Gene Deletion and Human DLG4 Gene Variation With Phenotypes Relevant to Autism Spectrum Disorders and Williams' Syndrome by Feyder, Michael, Karlsson, Rose-Marie, Mathur, Poonam, Lyman, Matthew, Bock, Roland, Momenan, Reza, Munasinghe, Jeeva, Scattoni, Maria Luisa, Ihne, Jessica, Camp, Marguerite, Graybeal, Carolyn, Strathdee, Douglas, Begg, Alison, Alvarez, Veronica A., Kirsch, Peter, Rietschel, Marcella, Cichon, Sven, Walter, Henrik, Meyer-Lindenberg, Andreas, Grant, Seth G.N., Holmes, Andrew

“…Objective:Research is increasingly linking autism spectrum disorders and other neurodevelopmental disorders to synaptic abnormalities (“synaptopathies”)…”
Get full text

Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories by Plath, Niels, Ohana, Ora, Dammermann, Björn, Errington, Mick L., Schmitz, Dietmar, Gross, Christina, Mao, Xiaosong, Engelsberg, Arne, Mahlke, Claudia, Welzl, Hans, Kobalz, Ursula, Stawrakakis, Anastasia, Fernandez, Esperanza, Waltereit, Robert, Bick-Sander, Anika, Therstappen, Eric, Cooke, Sam F., Blanquet, Veronique, Wurst, Wolfgang, Salmen, Benedikt, Bösl, Michael R., Lipp, Hans-Peter, Grant, Seth G.N., Bliss, Tim V.P., Wolfer, David P., Kuhl, Dietmar

“…Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of…”
Get full text

Architecture of the Mouse Brain Synaptome by Zhu, Fei, Cizeron, Mélissa, Qiu, Zhen, Benavides-Piccione, Ruth, Kopanitsa, Maksym V., Skene, Nathan G., Koniaris, Babis, DeFelipe, Javier, Fransén, Erik, Komiyama, Noboru H., Grant, Seth G.N.

“…Synapses are found in vast numbers in the brain and contain complex proteomes. We developed genetic labeling and imaging methods to examine synaptic proteins…”
Get full text

A single‐synapse resolution survey of PSD95‐positive synapses in twenty human brain regions by Curran, Olimpia E., Qiu, Zhen, Smith, Colin, Grant, Seth G.N.

“…Mapping the molecular composition of individual excitatory synapses across the mouse brain reveals high synapse diversity with each brain region showing a…”
Get full text

Developmental disruption and restoration of brain synaptome architecture in the murine Pax6 neurodevelopmental disease model by Tomas-Roca, Laura, Qiu, Zhen, Fransén, Erik, Gokhale, Ragini, Bulovaite, Edita, Price, David J., Komiyama, Noboru H., Grant, Seth G. N.

“…Neurodevelopmental disorders of genetic origin delay the acquisition of normal abilities and cause disabling phenotypes. Nevertheless, spontaneous attenuation…”
Get full text

Selective vulnerability of tripartite synapses in amyotrophic lateral sclerosis by Broadhead, Matthew J., Bonthron, Calum, Waddington, Julia, Smith, William V., Lopez, Maite F., Burley, Sarah, Valli, Jessica, Zhu, Fei, Komiyama, Noboru H., Smith, Colin, Grant, Seth G. N., Miles, Gareth B.

“…Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder. Separate lines of evidence suggest that synapses and astrocytes play a role in the…”
Get full text

A unified resource and configurable model of the synapse proteome and its role in disease by Sorokina, Oksana, Mclean, Colin, Croning, Mike D. R., Heil, Katharina F., Wysocka, Emilia, He, Xin, Sterratt, David, Grant, Seth G. N., Simpson, T. Ian, Armstrong, J. Douglas

“…Genes encoding synaptic proteins are highly associated with neuronal disorders many of which show clinical co-morbidity. We integrated 58 published synaptic…”
Get full text