Search Results - "Grant, Roberta L."

Approaches for describing and communicating overall uncertainty in toxicity characterizations: U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS) as a case study by Beck, Nancy B., Becker, Richard A., Erraguntla, Neeraja, Farland, William H., Grant, Roberta L., Gray, George, Kirman, Christopher, LaKind, Judy S., Jeffrey Lewis, R., Nance, Patricia, Pottenger, Lynn H., Santos, Susan L., Shirley, Stephanie, Simon, Ted, Dourson, Michael L.

“…Single point estimates of human health hazard/toxicity values such as a reference dose (RfD) are generally used in chemical hazard and risk assessment programs…”
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Primary cultures of rabbit corneal epithelial cells as an experimental model to evaluate ocular toxicity and explore modes of action of toxic injury by Grant, Roberta L.

“…In vivo and in vitro animal models are used to investigate the toxicological modes of action of a substance as surrogates for humans since it is not ethical to…”
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Spatial and temporal trend evaluation of ambient concentrations of 1,3-butadiene and chloroprene in Texas by Grant, Roberta L., Leopold, Vincent, McCant, Darrell, Honeycutt, Michael

“…This paper provides information on 1,3-butadiene (BD) and chloroprene as atmospheric pollutants in Texas and reviews available emission estimates and…”
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Emissions and ambient air monitoring trends of lower olefins across Texas from 2002 to 2012 by Myers, Jessica L., Phillips, Tracie, Grant, Roberta L.

“…•Monitored annual averages of evaluated olefins were well below their respective AMCVs.•Industry reported emissions data does not always correlate with…”
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Health- and vegetative-based effect screening values for ethylene by Erraguntla, Neeraja K., Grant, Roberta L.

“…Ethylene (ET) is ubiquitous in the environment and is produced both naturally and due to anthropogenic sources. Interestingly, the majority of ambient ET…”
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Use of In Vivo and In Vitro Data to Derive a Chronic Reference Value for Crotonaldehyde Based on Relative Potency to Acrolein by Grant, Roberta L., Jenkins, Allison F.

“…The Texas Commission on Environmental Quality (TCEQ) conducted a chronic inhalation noncancer toxicity assessment for crotonaldehyde (CRO). Since there were…”
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Development of a chronic inhalation reference value for hexamethylenediamine using an exposure model based on the dihydrochloride salt by Myers, Jessica L., Grant, Roberta L.

“…The Texas Commission on Environmental Quality has developed a chronic inhalation Reference Value (ReV) for hexamethylenediamine (HMDA, CAS 124-09-4) based on…”
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Assessment of chronic inhalation non-cancer toxicity for diethylamine by Grant, Roberta L., Taiwo, Samuel O., McCant, Darrell

“…A non-cancer inhalation chronic toxicity assessment for diethylamine (DEA, CAS number 109-89-7) was conducted by the Texas Commission on Environmental Quality…”
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An updated inhalation unit risk factor for arsenic and inorganic arsenic compounds based on a combined analysis of epidemiology studies by Erraguntla, Neeraja K., Sielken, Robert L., Valdez-Flores, Ciriaco, Grant, Roberta L.

“…► TCEQ URF used exposure estimates from Asarco, Anaconda, and Ronnskar smelters. ► The USEPA URF used exposure estimates only from Asarco and Anaconda…”
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Impact of three interactive Texas state regulatory programs to decrease ambient air toxic levels by Capobianco, Tara, Hildebrand, Susana M., Honeycutt, Michael, Lee, Jong-Song, McCant, Darrell, Grant, Roberta L.

“…The Federal Clean Air Act (FCAA) framework envisions a federal-state partnership whereby the development of regulations may be at the federal level or state…”
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Development of a Unit Risk Factor for 1,3-Butadiene Based on an Updated Carcinogenic Toxicity Assessment by Grant, Roberta L, Haney, Joseph, Curry, Angela L, Honeycutt, Michael

“…The Texas Commission on Environmental Quality (TCEQ) has developed an inhalation unit risk factor (URF) for 1,3-butadiene based on leukemia mortality in an…”
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A Chronic Reference Value for 1,3-Butadiene Based on an Updated Noncancer Toxicity Assessment by Grant, Roberta L., Haney, Joseph, Curry, Angela L., Honeycutt, Michael

“…A chronic noncancer toxicity assessment for 1,3-butadiene (BD) has been conducted by the Texas Commission on Environmental Quality (TCEQ) using information not…”
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Development of a unit risk factor for nickel and inorganic nickel compounds based on an updated carcinogenic toxicity assessment by Haney, Joseph T., McCant, Darrell D., Sielken, Robert L., Valdez-Flores, Ciriaco, Grant, Roberta L.

“…► The two cohorts used for URF development had more environmentally-relevant exposure. ► Grimsrud et al. (2003) has not previously been used to derive URF…”
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Evaluation of acute inhalation toxicity for chemicals with limited toxicity information by Grant, Roberta L., Kadlubar, Bernard J., Erraguntla, Neeraja K., Honeycutt, Michael

“…A large reference database consisting of acute inhalation no-observed-adverse-effect levels (NOAELs) and acute lethality data for 97 chemicals was compiled to…”
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Evaluation of surfactant cytotoxicity potential by primary cultures of ocular tissues: I. Characterization of rabbit corneal epithelial cells and initial injury and delayed toxicity studies by Grant, R L, Yao, C, Gabaldon, D, Acosta, D

“…This investigation was undertaken to develop cytotoxicity assay systems using primary cultures of rabbit corneal epithelial cells as an experimental model to…”
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Ratiometric measurement of intracellular pH of cultured cells with BCECF in a fluorescence multi-well plate reader by Grant, R L, Acosta, D

“…A number of methods have been developed to measure intracellular pH (pHi) because of its importance in intracellular events. A major advance in accurate pHi…”
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Prolonged Adverse Effects of Benzalkonium Chloride and Sodium Dodecyl Sulfate in a Primary Culture System of Rabbit Corneal Epithelial Cells by GRANT, ROBERTA L., ACOSTA, DANIEL

“…This investigation was undertaken to determine prolonged adverse effects of benzalkonium chloride (BzCl), a cationic surfactant, and sodium dodecyl sulfate…”
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Ratiometric Measurement of Extracellular pH of Cultured Cells with BCECF in a Fluorescence Multi-Well Plate Reader by Roberta L. Grant, Daniel Acosta

“…A number of methods have been developed to measure intracellular pH (pHi) because of its importance in intracellular events. A major advance in accurate pHi…”
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Comparative toxicity of tetracaine, proparacaine and cocaine evaluated with primary cultures of rabbit corneal epithelial cells by Grant, R L, Acosta, D

“…Cocaine was first used as a topical anesthetic for the eye by Dr Carl Koller in 1884. It became evident that this agent produced erosion of the corneal…”
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Shortcomings in USEPA's Approach for Predicting Risk Due to Consumption of Animal Food Products Impacted by Air Emissions from Hazardous Waste Combustion Facilities: A Case Study Involving Phthalates by Grant, Roberta L., Rodriguez, Rosita J., Hofelt, Chris S., Haws, Laurie C.

“…As a part of the permitting process for hazardous waste combustion facilities, regulatory agencies are now conducting site-specific, multipathway risk…”
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