Search Results - "Grant, Rhiannon D"

Targeting Lysyl Oxidase Family Meditated Matrix Cross-Linking as an Anti-Stromal Therapy in Solid Tumours by Setargew, Yordanos F I, Wyllie, Kaitlin, Grant, Rhiannon D, Chitty, Jessica L, Cox, Thomas R

“…The lysyl oxidase (LOX) family of enzymes are a major driver in the biogenesis of desmoplastic matrix at the primary tumour and secondary metastatic sites…”
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A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer by Chitty, Jessica L, Yam, Michelle, Perryman, Lara, Parker, Amelia L, Skhinas, Joanna N, Setargew, Yordanos F I, Mok, Ellie T Y, Tran, Emmi, Grant, Rhiannon D, Latham, Sharissa L, Pereira, Brooke A, Ritchie, Shona C, Murphy, Kendelle J, Trpceski, Michael, Findlay, Alison D, Melenec, Pauline, Filipe, Elysse C, Nadalini, Audrey, Velayuthar, Sipiththa, Major, Gretel, Wyllie, Kaitlin, Papanicolaou, Michael, Ratnaseelan, Shivanjali, Phillips, Phoebe A, Sharbeen, George, Youkhana, Janet, Russo, Alice, Blackwell, Antonia, Hastings, Jordan F, Lucas, Morghan C, Chambers, Cecilia R, Reed, Daniel A, Stoehr, Janett, Vennin, Claire, Pidsley, Ruth, Zaratzian, Anaiis, Da Silva, Andrew M, Tayao, Michael, Charlton, Brett, Herrmann, David, Nobis, Max, Clark, Susan J, Biankin, Andrew V, Johns, Amber L, Croucher, David R, Nagrial, Adnan, Gill, Anthony J, Grimmond, Sean M, Pajic, Marina, Timpson, Paul, Jarolimek, Wolfgang, Cox, Thomas R

“…The lysyl oxidase family represents a promising target in stromal targeting of solid tumors due to the importance of this family in crosslinking and…”
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The Mini‐Organo: A rapid high‐throughput 3D coculture organotypic assay for oncology screening and drug development by Chitty, Jessica L., Skhinas, Joanna N., Filipe, Elysse C., Wang, Shan, Cupello, Carmen Rodriguez, Grant, Rhiannon D., Yam, Michelle, Papanicolaou, Michael, Major, Gretel, Zaratzian, Anaiis, Da Silva, Andrew M., Tayao, Michael, Vennin, Claire, Timpson, Paul, Madsen, Chris D., Cox, Thomas R.

“…Background The use of in vitro cell cultures is a powerful tool for obtaining key insights into the behaviour and response of cells to interventions in normal…”
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