Search Results - "Grant, Oliver C."

Analysis of the SARS-CoV-2 spike protein glycan shield reveals implications for immune recognition by Grant, Oliver C., Montgomery, David, Ito, Keigo, Woods, Robert J.

“…Here we have generated 3D structures of glycoforms of the spike (S) glycoprotein from SARS-CoV-2, based on reported 3D structures and glycomics data for the…”
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Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions by Kim, So Young, Jin, Weihua, Sood, Amika, Montgomery, David W., Grant, Oliver C., Fuster, Mark M., Fu, Li, Dordick, Jonathan S., Woods, Robert J., Zhang, Fuming, Linhardt, Robert J.

“…Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has resulted in a pandemic and continues to spread around the globe at an unprecedented…”
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Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor by Zhao, Peng, Praissman, Jeremy L., Grant, Oliver C., Cai, Yongfei, Xiao, Tianshu, Rosenbalm, Katelyn E., Aoki, Kazuhiro, Kellman, Benjamin P., Bridger, Robert, Barouch, Dan H., Brindley, Melinda A., Lewis, Nathan E., Tiemeyer, Michael, Chen, Bing, Woods, Robert J., Wells, Lance

“…The SARS-CoV-2 betacoronavirus uses its highly glycosylated trimeric Spike protein to bind to the cell surface receptor angiotensin converting enzyme 2 (ACE2)…”
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Recent H3N2 Viruses Have Evolved Specificity for Extended, Branched Human-type Receptors, Conferring Potential for Increased Avidity by Peng, Wenjie, de Vries, Robert P., Grant, Oliver C., Thompson, Andrew J., McBride, Ryan, Tsogtbaatar, Buyankhishig, Lee, Peter S., Razi, Nahid, Wilson, Ian A., Woods, Robert J., Paulson, James C.

“…Human and avian influenza viruses recognize different sialic acid-containing receptors, referred to as human-type (NeuAcα2-6Gal) and avian-type (NeuAcα2-3Gal),…”
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O-glycosylation on cerebrospinal fluid and plasma apolipoprotein E differs in the lipid-binding domain by Flowers, Sarah A, Grant, Oliver C, Woods, Robert J, Rebeck, G William

“…The O-glycoprotein apolipoprotein E (APOE), the strongest genetic risk factor for Alzheimer's disease, associates with lipoproteins. Cerebrospinal fluid (CSF)…”
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PD-L1 Glycosylation and Its Impact on Binding to Clinical Antibodies by Benicky, Julius, Sanda, Miloslav, Brnakova Kennedy, Zuzana, Grant, Oliver C, Woods, Robert J, Zwart, Alan, Goldman, Radoslav

“…Immune checkpoint inhibitors, including PD-L1/PD-1, are key regulators of the immune response and promising targets in cancer immunotherapy. N-glycosylation of…”
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Three mutations switch H7N9 influenza to human-type receptor specificity by de Vries, Robert P, Peng, Wenjie, Grant, Oliver C, Thompson, Andrew J, Zhu, Xueyong, Bouwman, Kim M, de la Pena, Alba T Torrents, van Breemen, Marielle J, Ambepitiya Wickramasinghe, Iresha N, de Haan, Cornelis A M, Yu, Wenli, McBride, Ryan, Sanders, Rogier W, Woods, Robert J, Verheije, Monique H, Wilson, Ian A, Paulson, James C

“…The avian H7N9 influenza outbreak in 2013 resulted from an unprecedented incidence of influenza transmission to humans from infected poultry. The majority of…”
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Integrated Omics and Computational Glycobiology Reveal Structural Basis for Influenza A Virus Glycan Microheterogeneity and Host Interactions by Khatri, Kshitij, Klein, Joshua A., White, Mitchell R., Grant, Oliver C., Leymarie, Nancy, Woods, Robert J., Hartshorn, Kevan L., Zaia, Joseph

“…Despite sustained biomedical research effort, influenza A virus remains an imminent threat to the world population and a major healthcare burden. The challenge…”
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Induction of Antibodies Directed Against Branched Core O‐Mannosyl Glycopeptides—Selectivity Complimentary to the ConA Lectin by Yu, Jin, Grant, Oliver C., Pett, Christian, Stahl, Sabine, Woods, Robert J., Westerlind, Ulrika

“…Mammalian protein O‐mannosylation, initiated by attachment of α‐mannopyranose to Ser or Thr residues, comprise a group of post‐translational modifications…”
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Landscape and selection of vaccine epitopes in SARS-CoV-2 by Smith, Christof C, Olsen, Kelly S, Gentry, Kaylee M, Sambade, Maria, Beck, Wolfgang, Garness, Jason, Entwistle, Sarah, Willis, Caryn, Vensko, Steven, Woods, Allison, Fini, Misha, Carpenter, Brandon, Routh, Eric, Kodysh, Julia, O'Donnell, Timothy, Haber, Carsten, Heiss, Kirsten, Stadler, Volker, Garrison, Erik, Sandor, Adam M, Ting, Jenny P Y, Weiss, Jared, Krajewski, Krzysztof, Grant, Oliver C, Woods, Robert J, Heise, Mark, Vincent, Benjamin G, Rubinsteyn, Alex

“…Early in the pandemic, we designed a SARS-CoV-2 peptide vaccine containing epitope regions optimized for concurrent B cell, CD4 T cell, and CD8 T cell…”
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Gly-Spec: a webtool for predicting glycan specificity by integrating glycan array screening data and 3D structure by Grant, Oliver C, Xue, Xingran, Ra, Delaram, Khatamian, Alireza, Foley, Bethany L, Woods, Robert J

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Directed Evolution of Therapeutic Antibodies Targeting Glycosylation in Cancer by Amon, Ron, Rosenfeld, Ronit, Perlmutter, Shahar, Grant, Oliver C., Yehuda, Sharon, Borenstein-Katz, Aliza, Alcalay, Ron, Marshanski, Tal, Yu, Hai, Diskin, Ron, Woods, Robert J., Chen, Xi, Padler-Karavani, Vered

“…Glycosylation patterns commonly change in cancer, resulting in expression of tumor-associated carbohydrate antigens (TACA). While promising, currently…”
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The influence of N-linked glycans on the molecular dynamics of the HIV-1 gp120 V3 loop by Wood, Natasha T, Fadda, Elisa, Davis, Robert, Grant, Oliver C, Martin, Joanne C, Woods, Robert J, Travers, Simon A

“…N-linked glycans attached to specific amino acids of the gp120 envelope trimer of a HIV virion can modulate the binding affinity of gp120 to CD4, influence…”
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Computational screening of the human TF-glycome provides a structural definition for the specificity of anti-tumor antibody JAA-F11 by Tessier, Matthew B, Grant, Oliver C, Heimburg-Molinaro, Jamie, Smith, David, Jadey, Snehal, Gulick, Andrew M, Glushka, John, Deutscher, Susan L, Rittenhouse-Olson, Kate, Woods, Robert J

“…Recombinant antibodies are of profound clinical significance; yet, anti-carbohydrate antibodies are prone to undesirable cross-reactivity with structurally…”
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Hierarchical Multivalent Effects Control Influenza Host Specificity by Overeem, Nico J, Hamming, P. H. Erik, Grant, Oliver C, Di Iorio, Daniele, Tieke, Malte, Bertolino, M. Candelaria, Li, Zeshi, Vos, Gaël, de Vries, Robert P, Woods, Robert J, Tito, Nicholas B, Boons, Geert-Jan P. H, van der Vries, Erhard, Huskens, Jurriaan

“…Understanding how emerging influenza viruses recognize host cells is critical in evaluating their zoonotic potential, pathogenicity, and transmissibility…”
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Rapidly Display Glycan Symbols in 3D Structures: 3D-SNFG in LiteMol by Sehnal, David, Grant, Oliver C

“…The representation of carbohydrates in 3D space using symbols is a powerful visualization method, but such representations are lacking in currently available…”
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Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin–glycan specificities in a natural context by Nielsen, Mathias Ingemann, Stegmayr, John, Grant, Oliver C., Yang, Zhang, Nilsson, Ulf J., Boos, Irene, Carlsson, Michael C., Woods, Robert J., Unverzagt, Carlo, Leffler, Hakon, Wandall, Hans H.

“…Galectins compose a protein family defined by a conserved sequence motif conferring affinity for β-galactose–containing glycans. Moreover, galectins gain…”
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Position-specific N- and O-glycosylation of the reactive center loop impacts neutrophil elastase-mediated proteolysis of corticosteroid-binding globulin by Chernykh, Anastasia, Abrahams, Jodie L, Grant, Oliver C, Kambanis, Lucas, Sumer-Bayraktar, Zeynep, Ugonotti, Julian, Kawahara, Rebeca, Corcilius, Leo, Payne, Richard J, Woods, Robert J, Thaysen-Andersen, Morten

“…Corticosteroid-binding globulin (CBG) delivers anti-inflammatory cortisol to inflamed tissues through proteolysis of an exposed reactive center loop (RCL) by…”
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Hyper-truncated Asn355- and Asn391-glycans modulate the activity of neutrophil granule myeloperoxidase by Tjondro, Harry C., Ugonotti, Julian, Kawahara, Rebeca, Chatterjee, Sayantani, Loke, Ian, Chen, Siyun, Soltermann, Fabian, Hinneburg, Hannes, Parker, Benjamin L., Venkatakrishnan, Vignesh, Dieckmann, Regis, Grant, Oliver C., Bylund, Johan, Rodger, Alison, Woods, Robert J., Karlsson-Bengtsson, Anna, Struwe, Weston B., Thaysen-Andersen, Morten

“…Myeloperoxidase (MPO) plays essential roles in neutrophil-mediated immunity via the generation of reactive oxidation products. Complex carbohydrates decorate…”
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Recent advances in employing molecular modelling to determine the specificity of glycan-binding proteins by Grant, Oliver C, Woods, Robert J

“…•Recent innovations in carbohydrate docking enhance 3D structure prediction accuracy.•Glycan array screening data can be used to filter and validate docking…”
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