Search Results - "Grant, Marianne K.O."

Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration by Liu, Peng, Reed, Miranda N., Kotilinek, Linda A., Grant, Marianne K.O., Forster, Colleen L., Qiang, Wei, Shapiro, Samantha L., Reichl, John H., Chiang, Angie C.A., Jankowsky, Joanna L., Wilmot, Carrie M., Cleary, James P., Zahs, Kathleen R., Ashe, Karen H.

“…The accumulation of amyloid-β (Aβ) as amyloid fibrils and toxic oligomers is an important step in the development of Alzheimer’s disease (AD). However, there…”
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CYP1B1 as a therapeutic target in cardio-oncology by Carrera, Alexa N, Grant, Marianne K O, Zordoky, Beshay N

“…Cardiovascular complications have been frequently reported in cancer patients and survivors, mainly because of various cardiotoxic cancer treatments. Despite…”
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Canagliflozin mitigates carfilzomib-induced endothelial apoptosis via an AMPK-dependent pathway by Dabour, Mohamed S., Abdelgawad, Ibrahim Y., Grant, Marianne K.O., El-Sawaf, Engie S., Zordoky, Beshay N.

“…Carfilzomib (CFZ) is a proteasome inhibitor approved for relapsed/refractory multiple myeloma (MM) but its clinical use is limited by cardiovascular toxicity…”
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Losmapimod ameliorates doxorubicin-induced cardiotoxicity through attenuating senescence and inflammatory pathways by Dabour, Mohamed S., Abdelgawad, Ibrahim Y., Sadaf, Bushra, Daniel, Mary R., Grant, Marianne K.O., Seelig, Davis, Zordoky, Beshay N.

“…Irreversible cardiotoxicity limits the clinical application of doxorubicin (DOX). DOX-induced cardiotoxicity has been associated with induction of senescence…”
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Sexual Dimorphism in Doxorubicin-induced Systemic Inflammation: Implications for Hepatic Cytochrome P450 Regulation by Grant, Marianne K O, Abdelgawad, Ibrahim Y, Lewis, Christine A, Zordoky, Beshay N

“…Doxorubicin (DOX) is an effective chemotherapeutic agent used to treat a wide variety of malignancies. In addition to its multi-organ toxicity, DOX treatment…”
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Leveraging the Cardio-Protective and Anticancer Properties of Resveratrol in Cardio-Oncology by Abdelgawad, Ibrahim Y, Grant, Marianne K O, Zordoky, Beshay N

“…Cardio-oncology is a clinical/scientific discipline which aims to prevent and/or treat cardiovascular diseases in cancer patients. Although a large number of…”
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A Cautionary Tale: Endogenous Biotinylated Proteins and Exogenously-Introduced Protein A Cause Antibody-Independent Artefacts in Western Blot Studies of Brain-Derived Proteins by Grant, Marianne K O, Shapiro, Samantha L, Ashe, Karen H, Liu, Peng, Zahs, Kathleen R

“…Antibodies are commonly used to detect or isolate proteins from biological samples. Much attention has been paid to the potential for poorly-characterized…”
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Synthesis and evaluation of xanomeline analogs : Probing the wash-resistant phenomenon at the M1 muscarinic acetylcholine receptor by KANE, Brian E, GRANT, Marianne K. O, EL-FAKAHANY, Esam E, FERGUSON, David M

“…A series of xanomeline analogs were synthesized and evaluated for binding at the M(1) muscarinic acetylcholine receptor (M(1) receptor). Specifically,…”
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Long-term changes in the muscarinic M1 receptor induced by instantaneous formation of wash-resistant xanomeline-receptor complex by De Lorme, Kayla C, Grant, Marianne K O, Noetzel, Meredith J, Polson, Sonya B, El-Fakahany, Esam E

“…Unlike other M1 muscarinic acetylcholine receptor agonists, xanomeline demonstrates a unique mode of binding to the receptor. It not only binds reversibly to…”
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Therapeutic interventions targeting the nitric oxide system: Current and potential uses in obstetrics, bone disease and erectile dysfunction by Grant, Marianne K.O, El-Fakahany, Esam E

“…Nitric oxide is involved in a countless number of physiological processes and is known to have cytoprotective as well as cytotoxic effects. Increased knowledge…”
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Endogenous expression of nNOS protein in several neuronal cell lines by Grant, Marianne K.O, Cuadra, Adolfo E, El-Fakahany, Esam E

“…Several neuronal cell lines were screened for endogenous expression of neuronal nitric oxide synthase (nNOS) protein using Western blot analysis. Detectable…”
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Doxorubicin Cardiotoxicity in Young Tumor‐Bearing Mice by Abdelgawad, Ibrahim Y., Grant, Marianne K.O., Lewis, Christine, Popescu, Flavia, Largaespada, David, Zordoky, Beshay N.

“…Abstract only Background Childhood cancer survivors have about 15‐times higher risk of heart failure than their siblings mainly due to the cardiotoxicity of…”
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Sex-related differences in delayed doxorubicin-induced cardiac dysfunction in C57BL/6 mice by Abdelgawad, Ibrahim Y., George, Benu, Grant, Marianne K. O., Huang, Yingbo, Shan, Yuting, Huang, R. Stephanie, Zordoky, Beshay N.

“…Cancer survivors may experience long-term cardiovascular complications due to chemotherapeutic drugs such as doxorubicin (DOX). The exact mechanism of delayed…”
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Lack of sexual dimorphism in a mouse model of isoproterenol-induced cardiac dysfunction by Grant, Marianne K. O, Abdelgawad, Ibrahim Y, Lewis, Christine A, Seelig, Davis, Zordoky, Beshay N, Lionetti, Vincenzo

“…Sex-related differences in cardiovascular diseases are highly complex in humans and model-dependent in experimental laboratory animals. The objective of this…”
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Metformin mitigates SASP secretion and LPS-triggered hyper-inflammation in Doxorubicin-induced senescent endothelial cells by Abdelgawad, Ibrahim Y, Agostinucci, Kevin, Sadaf, Bushra, Grant, Marianne K O, Zordoky, Beshay N

“…Doxorubicin (DOX), a chemotherapeutic drug, induces senescence and increases the secretion of senescence-associated secretory phenotype (SASP) in endothelial…”
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Doxorubicin Paradoxically Ameliorates Tumor-Induced Inflammation in Young Mice by Abdelgawad, Ibrahim Y, Grant, Marianne K O, Popescu, Flavia E, Largaespada, David A, Zordoky, Beshay N

“…Doxorubicin (DOX) is one of the most widely used chemo-therapeutic agents in pediatric oncology. DOX elicits an inflammatory response in multiple organs, which…”
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Regulation of acetylcholine binding by ATP at the muscarinic M1 receptor in intact CHO cells by GRANT, M. K. O, CHRISTOPOULOS, A, EL-FAKAHANY, E. E

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Human cerebrospinal fluid 6E10-immunoreactive protein species contain amyloid precursor protein fragments by Grant, Marianne K O, Handoko, Maureen, Rozga, Malgorzata, Brinkmalm, Gunnar, Portelius, Erik, Blennow, Kaj, Ashe, Karen H, Zahs, Kathleen R, Liu, Peng

“…In a previous study, we reported that levels of two types of protein species-a type of ~55-kDa species and a type of ~15-kDa species-are elevated in the lumbar…”
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Exposure to Doxorubicin Modulates the Cardiac Response to Isoproterenol in Male and Female Mice by Agostinucci, Kevin, Grant, Marianne K O, Melaku, Wongel, Nair, Chandini, Zordoky, Beshay N

“…Sex is a salient risk factor in the development of doxorubicin-induced cardiotoxicity. Sex differences in the heart's ability to respond to hypertrophic…”
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Sexual dimorphism of acute doxorubicin-induced nephrotoxicity in C57Bl/6 mice by Grant, Marianne K O, Seelig, Davis M, Sharkey, Leslie C, Choi, Wan S V, Abdelgawad, Ibrahim Y, Zordoky, Beshay N

“…Doxorubicin (DOX) is a chemotherapeutic agent that has been reported to cause nephrotoxicity in rodent models and to a lesser degree in cancer patients. Female…”
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