Search Results - "Grant, K."

ESKAPEing the labyrinth of antibacterial discovery by Tommasi, Ruben, Brown, Dean G., Walkup, Grant K., Manchester, John I., Miller, Alita A.

“…Incentives are increasingly available for the development of new drugs to tackle antibiotic resistance, but major scientific challenges remain, such as…”
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Mediterranean climate and oceanography, and the periodic development of anoxic events (sapropels) by Rohling, E.J., Marino, G., Grant, K.M.

“…Mediterranean sapropels are layers with elevated organic carbon concentrations that contrast with surrounding sediments, which are organic poor. Sapropels…”
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Rapid coupling between ice volume and polar temperature over the past 150,000 years by Grant, K. M., Rohling, E. J., Bar-Matthews, M., Ayalon, A., Medina-Elizalde, M., Ramsey, C. Bronk, Satow, C., Roberts, A. P.

“…A new approach to dating a continuous sea-level record, using speleothem U–Th ages, shows that past variations in global ice volume occurred within centuries…”
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Avibactam is a covalent, reversible, non–β-lactam β-lactamase inhibitor by Ehmann, David E, Jahić, Haris, Ross, Philip L, Gu, Rong-Fang, Hu, Jun, Kern, Gunther, Walkup, Grant K, Fisher, Stewart L

“…Avibactam is a β-lactamase inhibitor that is in clinical development, combined with β-lactam partners, for the treatment of bacterial infections comprising…”
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Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton by Hu, Hai, Juvekar, Ashish, Lyssiotis, Costas A., Lien, Evan C., Albeck, John G., Oh, Doogie, Varma, Gopal, Hung, Yin Pun, Ullas, Soumya, Lauring, Josh, Seth, Pankaj, Lundquist, Mark R., Tolan, Dean R., Grant, Aaron K., Needleman, Daniel J., Asara, John M., Cantley, Lewis C., Wulf, Gerburg M.

“…The phosphoinositide 3-kinase (PI3K) pathway regulates multiple steps in glucose metabolism and also cytoskeletal functions, such as cell movement and…”
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Comprehensive Genomic Analysis in NRG Oncology/RTOG 9802: A Phase III Trial of Radiation Versus Radiation Plus Procarbazine, Lomustine (CCNU), and Vincristine in High-Risk Low-Grade Glioma by Bell, Erica H, Zhang, Peixin, Shaw, Edward G, Buckner, Jan C, Barger, Geoffrey R, Bullard, Dennis E, Mehta, Minesh P, Gilbert, Mark R, Brown, Paul D, Stelzer, Keith J, McElroy, Joseph P, Fleming, Jessica L, Timmers, Cynthia D, Becker, Aline P, Salavaggione, Andrea L, Liu, Ziyan, Aldape, Kenneth, Brachman, David G, Gertler, Stanley Z, Murtha, Albert D, Schultz, Christopher J, Johnson, David, Laack, Nadia N, Hunter, Grant K, Crocker, Ian R, Won, Minhee, Chakravarti, Arnab

“…NRG Oncology/RTOG 9802 (ClinicalTrials.gov Identifier: NCT00003375) is a practice-changing study for patients with WHO low-grade glioma (LGG, grade II), as it…”
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Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques by Lee, M. R., Shnitko, T. A., Blue, S. W., Kaucher, A. V., Winchell, A. J., Erikson, D. W., Grant, K. A., Leggio, L.

“…Oxytocin may have promise as a treatment for neuropsychiatric disorders. Its therapeutic effect may depend on its ability to enter the brain and bind to the…”
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Therapeutic Protein Kinase Inhibitors by Grant, S. K

“…Protein kinase inhibitors represent an important and still emerging class of targeted therapeutic agents. Drug discovery and development strategies have…”
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Interim analysis of pandemic influenza (H1N1) 2009 in Australia: surveillance trends, age of infection and effectiveness of seasonal vaccination by Kelly, H, Grant, K

“…Between May and September each year, influenza sentinel surveillance is conducted in general practices in Melbourne and the state of Victoria in southern…”
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Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration by Hoover, Brian R., Reed, Miranda N., Su, Jianjun, Penrod, Rachel D., Kotilinek, Linda A., Grant, Marianne K., Pitstick, Rose, Carlson, George A., Lanier, Lorene M., Yuan, Li-Lian, Ashe, Karen H., Liao, Dezhi

“…The microtubule-associated protein tau accumulates in Alzheimer's and other fatal dementias, which manifest when forebrain neurons die. Recent advances in…”
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Sea-level and deep-sea-temperature variability over the past 5.3 million years by Rohling, E. J., Foster, G. L., Grant, K. M., Marino, G., Roberts, A. P., Tamisiea, M. E., Williams, F.

“…Ice volume (and hence sea level) and deep-sea temperature are key measures of global climate change. Sea level has been documented using several independent…”
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The Autism-Spectrum Quotient and Visual Search: Shallow and Deep Autistic Endophenotypes by Gregory, B. L., Plaisted-Grant, K. C.

“…A high Autism-Spectrum Quotient (AQ) score (Baron-Cohen et al. in J Autism Dev Disord 31(1):5–17, 2001 ) is increasingly used as a proxy in empirical studies…”
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Bipolar seesaw control on last interglacial sea level by Marino, G., Rohling, E. J., Rodríguez-Sanz, L., Grant, K. M., Heslop, D., Roberts, A. P., Stanford, J. D., Yu, J.

“…A synthesis of new and existing data allows Heinrich Stadial 11 (HS11), a prominent Northern Hemisphere cold event, to be linked to the timing of peak…”
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Secret messengers: Extracellular RNA communication in the immune system by Nation, Grant K, Saffold, Cherie E, Pua, Heather H

“…One of the hallmarks of the immune system is a dynamic landscape of cellular communication through the secretion of soluble factors, production of cell‐bound…”
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Sea-level variability over five glacial cycles by Grant, K. M., Rohling, E. J., Ramsey, C. Bronk, Cheng, H., Edwards, R. L., Florindo, F., Heslop, D., Marra, F., Roberts, A. P., Tamisiea, M. E., Williams, F.

“…Research on global ice-volume changes during Pleistocene glacial cycles is hindered by a lack of detailed sea-level records for time intervals older than the…”
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Antarctic temperature and global sea level closely coupled over the past five glacial cycles by Rohling, E. J, Grant, K, Bolshaw, M, Roberts, A. P, Siddall, M, Hemleben, Ch, Kucera, M

“…Ice cores from Antarctica record temperature and atmospheric carbon dioxide variations over the past six glacial cycles. Yet concomitant records of sea-level…”
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Endogenous circadian regulation of female reproductive hormones by Rahman, Shadab A, Grant, Leilah K, Gooley, Joshua J, Rajaratnam, Shantha M W, Czeisler, Charles A, Lockley, Steven W

“…Studies suggest that female reproductive hormones are under circadian regulation, although methodological differences have led to inconsistent findings. To…”
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Frequency-dependent diffusion kurtosis imaging in the human brain using an oscillating gradient spin echo sequence and a high-performance head-only gradient by Dai, Erpeng, Zhu, Ante, Yang, Grant K., Quah, Kristin, Tan, Ek T., Fiveland, Eric, Foo, Thomas K.F., McNab, Jennifer A.

“…•Simultaneously high b-value and frequency OGSE diffusion encoding are achieved.•The frequency dependences of diffusivity and kurtosis are studied for human…”
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Kinetics of Avibactam Inhibition against Class A, C, and D β-Lactamases by Ehmann, David E., Jahić, Haris, Ross, Philip L., Gu, Rong-Fang, Hu, Jun, Durand-Réville, Thomas F., Lahiri, Sushmita, Thresher, Jason, Livchak, Stephania, Gao, Ning, Palmer, Tiffany, Walkup, Grant K., Fisher, Stewart L.

“…Avibactam is a non-β-lactam β-lactamase inhibitor with a spectrum of activity that includes β-lactamase enzymes of classes A, C, and selected D examples. In…”
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Commercial airline pilots' declining professional standing and increasing precarious employment by Maxwell, G. A., Grant, K.

“…With the advent of low-cost employment systems for pilots in commercial airlines, we address two questions: What are experienced UK-based, commercial airline…”
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