Search Results - "Grant, Ethan P"

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3 by Núñez, Gabriel, Kanneganti, Thirumala-Devi, Özören, Nesrin, Body-Malapel, Mathilde, Amer, Amal, Park, Jong-Hwan, Franchi, Luigi, Whitfield, Joel, Barchet, Winfried, Colonna, Marco, Vandenabeele, Peter, Bertin, John, Coyle, Anthony, Grant, Ethan P, Akira, Shizuo

“…Missense mutations in the CIAS1 gene cause three autoinflammatory disorders: familial cold autoinflammatory syndrome, Muckle-Wells syndrome and neonatal-onset…”
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Critical Role for NALP3/CIAS1/Cryopyrin in Innate and Adaptive Immunity through Its Regulation of Caspase-1 by Sutterwala, Fayyaz S., Ogura, Yasunori, Szczepanik, Marian, Lara-Tejero, Maria, Lichtenberger, G. Scott, Grant, Ethan P., Bertin, John, Coyle, Anthony J., Galán, Jorge E., Askenase, Philip W., Flavell, Richard A.

“…Mutations in the NALP3/CIAS1/cryopyrin gene are linked to three autoinflammatory disorders: Muckle-Wells syndrome, familial cold autoinflammatory syndrome, and…”
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Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis by Lara-Tejero, Maria, Sutterwala, Fayyaz S, Ogura, Yasunori, Grant, Ethan P, Bertin, John, Coyle, Anthony J, Flavell, Richard A, Galán, Jorge E

“…Caspase-1 is activated by a variety of stimuli after the assembly of the "inflammasome," an activating platform made up of a complex of the NOD-LRR family of…”
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MDP-induced interleukin-1β processing requires Nod2 and CIAS1/NALP3 by Pan, Qilin, Mathison, John, Fearns, Colleen, Kravchenko, Vladimir V., Da Silva Correia, Jean, Hoffman, Hal M., Kobayashi, Koichi S., Bertin, John, Grant, Ethan P., Coyle, Anthony J., Sutterwala, Fayyaz S., Ogura, Yasunori, Flavell, Richard A., Ulevitch, Richard J.

“…Nucleotide‐binding oligomerization domain (Nod)2 is a sensor of muramyl dipeptides (MDP) derived from bacterial peptidoglycan. Nod2 also plays a role in some…”
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Development of a new ARCHITECT automated periostin immunoassay by Jeanblanc, Nicolette M., Hemken, Philip M., Datwyler, Maria J., Brophy, Susan E., Manetz, T. Scott, Lee, Rozanne, Liang, Meina, Chowdhury, Partha S., Varkey, Reena, Grant, Ethan P., Streicher, Katie, Greenlees, Lydia, Ranade, Koustubh, Davis, Gerard J.

“…Periostin is being investigated as a potential biomarker for T-helper-2 (Th2)-driven asthma or eosinophilic inflammation and may help to identify patients more…”
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Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritis by Min, Soo-Hong, Wang, Yuanfan, Gonsiorek, Waldemar, Anilkumar, Gopinadhan, Kozlowski, Joseph, Lundell, Daniel, Fine, Jay S., Grant, Ethan P.

“…Neutrophils and monocytes are abundantly represented in the synovial fluid and tissue in rheumatoid arthritis patients. We therefore explored the effects of…”
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CCR2 and CXCR4 regulate peripheral blood monocyte pharmacodynamics and link to efficacy in experimental autoimmune encephalomyelitis by Wang, Yuanfan, Cui, Long, Gonsiorek, Waldemar, Min, Soo-Hong, Anilkumar, Gopinadhan, Rosenblum, Stuart, Kozlowski, Joseph, Lundell, Daniel, Fine, Jay S, Grant, Ethan P

“…CCR2 plays a key role in regulating monocyte trafficking to sites of inflammation and therefore has been the focus of much interest as a target for…”
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Essential role for the C5a receptor in regulating the effector phase of synovial infiltration and joint destruction in experimental arthritis by Grant, Ethan P, Picarella, Dominic, Burwell, Timothy, Delaney, Tracy, Croci, Alisa, Avitahl, Nicole, Humbles, Alison A, Gutierrez-Ramos, Jose-Carlos, Briskin, Michael, Gerard, Craig, Coyle, Anthony J

“…A characteristic feature of rheumatoid arthritis is the abundance of inflammatory cells in the diseased joint. Two major components of this infiltrate are…”
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A Phase 2 Randomized Controlled Study of Tralokinumab in Subjects with Idiopathic Pulmonary Fibrosis by Parker, Joseph M, Glaspole, Ian N, Lancaster, Lisa H, Haddad, Tarik J, She, Dewei, Roseti, Stephanie L, Fiening, Jon P, Grant, Ethan P, Kell, Chris M, Flaherty, Kevin R

“…IL-13 is a potential therapeutic target for idiopathic pulmonary fibrosis (IPF); preclinical data suggest a role in tissue fibrosis, and expression is…”
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Separate Pathways for Antigen Presentation by CD1 Molecules by Sugita, Masahiko, Grant, Ethan P, van Donselaar, Elly, Hsu, Victor W, Rogers, Rick A, Peters, Peter J, Brenner, Michael B

“…The ability to sample relevant intracellular compartments is necessary for effective antigen presentation. To detect peptide antigens, MHC class I and II…”
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Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages by Núñez, Gabriel, Franchi, Luigi, Amer, Amal, Body-Malapel, Mathilde, Kanneganti, Thirumala-Devi, Özören, Nesrin, Jagirdar, Rajesh, Inohara, Naohiro, Vandenabeele, Peter, Bertin, John, Coyle, Anthony, Grant, Ethan P

“…Gram-negative bacteria that replicate in the cytosol of mammalian macrophages can activate a signaling pathway leading to caspase-1 cleavage and secretion of…”
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SLE Plasma Profiling Identifies Unique Signatures of Lupus Nephritis and Discoid Lupus by Smith, Michael A., Henault, Jill, Karnell, Jodi L., Parker, Melissa L., Riggs, Jeffrey M., Sinibaldi, Dominic, Taylor, Devon K., Ettinger, Rachel, Grant, Ethan P., Sanjuan, Miguel A., Kolbeck, Roland, Petri, Michelle A., Casey, Kerry A.

“…Systemic lupus erythematosus (SLE) impacts multiple organ systems, although the causes of many individual SLE pathologies are poorly understood. This study was…”
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Distinct Roles of TLR2 and the Adaptor ASC in IL-1β/IL-18 Secretion in Response to Listeria monocytogenes by Özören, Nesrin, Masumoto, Junya, Franchi, Luigi, Kanneganti, Thirumala-Devi, Body-Malapel, Mathilde, Ertürk, İlkim, Jagirdar, Rajesh, Zhu, Li, Inohara, Naohiro, Bertin, John, Coyle, Anthony, Grant, Ethan P., Núñez, Gabriel

“…Abstract Apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (ASC) is an adaptor molecule that has recently been…”
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Differential Dependence of CD4+ CD25+ Regulatory and Natural Killer-Like T Cells on Signals Leading to NF-κB Activation by Schmidt-Supprian, Marc, Tian, Jane, Grant, Ethan P., Pasparakis, Manolis, Maehr, René, Ovaa, Huib, Ploegh, Hidde L., Coyle, Anthony J., Rajewsky, Klaus

“…Natural killer-like (NK) T, regulatory T ( T R), and memory type T cells display surface phenotypes reminiscent of activated T cells. Previously, we reported…”
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CD1-dependent dendritic cell instruction by Brenner, Michael B, Vincent, Michael S, Leslie, David S, Gumperz, Jenny E, Xiong, Xiaowei, Grant, Ethan P

“…Both microbial products and T cell factors influence dendritic cell (DC) maturation. However, it is not known which T cells are capable of interacting with DCs…”
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A role for the ubiquitin-dependent proteolytic pathway in MHC class l-restricted antigen presentation by Michalek, Michael T, Grant, Ethan P, Gramm, Colette, Goldberg, Alfred L, Rock, Kenneth L

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CD1a-, b-, and c-Restricted TCRs Recognize Both Self and Foreign Antigens by Vincent, Michael S, Xiong, Xiaowei, Grant, Ethan P, Peng, Wei, Brenner, Michael B

“…Individual CD1-restricted T cells can recognize either endogenous or foreign lipid Ags, but the extent to which the same CD1-restricted TCR can react to both…”
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I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion by Schmidt-Supprian, Marc, Tian, Jane, Ji, Hongbin, Terhorst, Cox, Bhan, Atul K, Grant, Ethan P, Pasparakis, Manolis, Casola, Stefano, Coyle, Anthony J, Rajewsky, Klaus

“…Signal transduction from proinflammatory stimuli leading to NF-kappa B-dependent gene expression is mediated by the I kappa B kinase 2 (IKK2/IKK beta)…”
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Fine Specificity of TCR Complementarity-Determining Region Residues and Lipid Antigen Hydrophilic Moieties in the Recognition of a CD1-Lipid Complex by Grant, Ethan P, Beckman, Evan M, Behar, Samuel M, Degano, Massimo, Frederique, Daphney, Besra, Gurdyal S, Wilson, Ian A, Porcelli, Steven A, Furlong, Stephen T, Brenner, Michael B

“…alphabeta TCR can recognize peptides presented by MHC molecules or lipids and glycolipids presented by CD1 proteins. Whereas the structural basis for…”
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A Mutant Cell with a Novel Defect in MHC Class I Quality Control by York, Ian A, Grant, Ethan P, Dahl, A. Maria, Rock, Kenneth L

“…COS7 (African Green Monkey kidney) cells stably transfected with the mouse MHC class I allele H-2K(b) were mutagenized, selected for low surface expression of…”
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