Search Results - "Grant, C"

Variability in donor leukocyte counts confound the use of common RNA sequencing data normalization strategies in transcriptomic biomarker studies performed with whole blood by O’Connell, Grant C.

“…Gene expression data generated from whole blood via next generation sequencing is frequently used in studies aimed at identifying mRNA-based biomarker panels…”
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Hemophagocytic lymphohistiocytosis: An update on pathogenesis, diagnosis, and therapy by Griffin, Georgia, Shenoi, Susan, Hughes, Grant C.

“…Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening state of immune hyperactivation that arises in the setting of genetic mutations and…”
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The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries by Grant, Michael C, Geoghegan, Luke, Arbyn, Marc, Mohammed, Zakaria, McGuinness, Luke, Clarke, Emily L, Wade, Ryckie G

“…To limit the spread of SARS-CoV-2, an evidence-based understanding of the symptoms is critical to inform guidelines for quarantining and testing. The most…”
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Progesterone and autoimmune disease by Hughes, Grant C

“…Abstract Sexual dimorphism in human immune systems is most apparent in the female predominance of certain autoimmune diseases (ADs) like systemic lupus…”
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Analysis of the SARS-CoV-2 spike protein glycan shield reveals implications for immune recognition by Grant, Oliver C., Montgomery, David, Ito, Keigo, Woods, Robert J.

“…Here we have generated 3D structures of glycoforms of the spike (S) glycoprotein from SARS-CoV-2, based on reported 3D structures and glycomics data for the…”
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Modulation of autoimmune rheumatic diseases by oestrogen and progesterone by Hughes, Grant C., Choubey, Divaker

“…Key Points Sexual dimorphism in the risk and expression of human autoimmune rheumatic diseases involves the immunomodulatory effects of postpubertal levels of…”
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Neutrophil extracellular traps as a potential source of autoantigen in cocaine-associated autoimmunity by Lood, Christian, Hughes, Grant C

“…Exposure to illicit cocaine and its frequent adulterant, levamisole, is associated with ANCAs targeting neutrophil elastase (NE), neutropenia and…”
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Cross-boundary human impacts compromise the Serengeti-Mara ecosystem by Veldhuis, Michiel P, Ritchie, Mark E, Ogutu, Joseph O, Morrison, Thomas A, Beale, Colin M, Estes, Anna B, Mwakilema, William, Ojwang, Gordon O, Parr, Catherine L, Probert, James, Wargute, Patrick W, Hopcraft, J Grant C, Olff, Han

“…Protected areas provide major benefits for humans in the form of ecosystem services, but landscape degradation by human activity at their edges may compromise…”
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Polarity-Switching Top Coats Enable Orientation of Sub–10-nm Block Copolymer Domains by Bates, Christopher M., Seshimo, Takehiro, Maher, Michael J., Durand, William J., Cushen, Julia D., Dean, Leon M., Blachut, Gregory, Ellison, Christopher J., Willson, C. Grant

“…Block copolymers (BCPs) must necessarily have high interaction parameters (χ), a fundamental measure of block incompatibility, to self-assemble into…”
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Declining oxygen in the global ocean and coastal waters by Breitburg, Denise, Levin, Lisa A, Oschlies, Andreas, Grégoire, Marilaure, Chavez, Francisco P, Conley, Daniel J, Garçon, Véronique, Gilbert, Denis, Gutiérrez, Dimitri, Isensee, Kirsten, Jacinto, Gil S, Limburg, Karin E, Montes, Ivonne, Naqvi, S W A, Pitcher, Grant C, Rabalais, Nancy N, Roman, Michael R, Rose, Kenneth A, Seibel, Brad A, Telszewski, Maciej, Yasuhara, Moriaki, Zhang, Jing

“…Oxygen is fundamental to life. Not only is it essential for the survival of individual animals, but it regulates global cycles of major nutrients and carbon…”
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Multiple stressors unpredictably affect primary producers and decomposition in a model freshwater ecosystem by Saqira, Sajida, Chariton, Anthony, Hose, Grant C.

“…Freshwater ecosystems are affected by various stressors, such as contamination and exotic species, making them amongst the most imperilled biological systems…”
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The impact of small groups on pre‐ and postcopulatory sexual selection in polyandrous populations by McDonald, Grant C.

“…Sexual selection is a key evolutionary force but varies widely between populations. Two key factors that influence sexual selection are the extent to which…”
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Donor white blood cell differential is the single largest determinant of whole blood gene expression patterns by O'Connell, Grant C., Wang, Jing, Smothers, Christine

“…It has become widely accepted that sample cellular composition is a significant determinant of the gene expression patterns observed in any transcriptomic…”
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Structure of sexual networks determines the operation of sexual selection by McDonald, Grant C., Pizzari, Tommaso

“…Sexual selection is a fundamental evolutionary process but remains debated, particularly in the complexity of polyandrous populations where females mate with…”
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Virtual discovery of melatonin receptor ligands to modulate circadian rhythms by Stein, Reed M., Kang, Hye Jin, McCorvy, John D., Glatfelter, Grant C., Jones, Anthony J., Che, Tao, Slocum, Samuel, Huang, Xi-Ping, Savych, Olena, Moroz, Yurii S., Stauch, Benjamin, Johansson, Linda C., Cherezov, Vadim, Kenakin, Terry, Irwin, John J., Shoichet, Brian K., Roth, Bryan L., Dubocovich, Margarita L.

“…The neuromodulator melatonin synchronizes circadian rhythms and related physiological functions through the actions of two G-protein-coupled receptors: MT 1…”
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Social group composition modulates the role of last male sperm precedence in post‐copulatory sexual selection by Morimoto, Juliano, McDonald, Grant C., Wigby, Stuart

“…In many species, the order in which males mate with a female explains much of the variation in paternity arising from post‐copulatory sexual selection…”
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Harmful algal blooms of the Benguela eastern boundary upwelling system by Pitcher, Grant C., Louw, Deon C.

“…•Paralytic and Diarrhetic Shellfish Poisoning pose greatest risk to human health.•Yessotoxins have been the cause of large invertebrate mortalities.•Prominent…”
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Dynamics of a morbillivirus at the domestic–wildlife interface: Canine distemper virus in domestic dogs and lions by Viana, Mafalda, Cleaveland, Sarah, Matthiopoulos, Jason, Halliday, Jo, Packer, Craig, Craft, Meggan E., Hampson, Katie, Czupryna, Anna, Dobson, Andrew P., Dubovi, Edward J., Ernest, Eblate, Fyumagwa, Robert, Hoare, Richard, Hopcraft, J. Grant C., Horton, Daniel L., Kaarek, Magai T., Kanellos, Theo, Lankester, Felix, Mentzel, Christine, Mlengeya, Titus, Mzimbiri, Imam, Takahashi, Emi, Willett, Brian, Haydon, Daniel T., Lembo, Tiziana

“…Significance Morbilliviruses are a growing concern because of their ability to infect multiple species. The spill-over of canine distemper virus (CDV) from…”
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Bioinformatic analysis of brain-specific miRNAs for identification of candidate traumatic brain injury blood biomarkers by O'Connell, Grant C., Smothers, Christine G., Winkelman, Chris

“…Detection of brain-specific miRNAs in the peripheral blood could serve as a surrogate marker of traumatic brain injury (TBI). Here, we systematically…”
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Analytical Models for Secular Descents in Hierarchical Triple Systems by Weldon, Grant C., Naoz, Smadar, Hansen, Bradley M. S.

“…Abstract Three-body systems are prevalent in nature, from planetary to stellar to supermassive black hole scales. In a hierarchical triple system, oscillations…”
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