Immune-related, lectin-like receptors are differentially expressed in the myeloid and lymphoid lineages of zebrafish

The identification of C-type lectin (Group V) natural killer (NK) cell receptors in bony fish has remained elusive. Analyses of the Fugu rubripes genome database failed to identify Group V C-type lectin domains (Zelensky and Gready, BMC Genomics 5:51, 2004) suggesting that bony fish, in general, may...

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Bibliographic Details
Published in:	Immunogenetics (New York) Vol. 58; no. 1; pp. 31 - 40
Main Authors:	Panagos, Patoula G, Dobrinski, Kimberly P, Chen, Xianghong, Grant, Amanda W, Traver, David, Djeu, Julie Y, Wei, Sheng, Yoder, Jeffrey A
Format:	Journal Article
Language:	English
Published:	United States Berlin/Heidelberg : Springer-Verlag 01-02-2006
Subjects:	Amino Acid Sequence Animals C-type lectin Cell Survival - physiology Chromosomes Chromosomes, Artificial, Bacterial Danio rerio Fugu rubripes ITIM Killer Cells, Natural - metabolism Lectins, C-Type - chemistry Lectins, C-Type - genetics Lectins, C-Type - metabolism Lectins, C-Type - physiology Lymphocytes - metabolism Models, Molecular Molecular Sequence Data Myeloid Cells - metabolism natural killer cells Phylogeny Signaling motifs Zebrafish - genetics Zebrafish - immunology Zebrafish - metabolism Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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Summary:	The identification of C-type lectin (Group V) natural killer (NK) cell receptors in bony fish has remained elusive. Analyses of the Fugu rubripes genome database failed to identify Group V C-type lectin domains (Zelensky and Gready, BMC Genomics 5:51, 2004) suggesting that bony fish, in general, may lack such receptors. Numerous Group II C-type lectin receptors, which are structurally similar to Group V (NK) receptors, have been characterized in bony fish. By searching the zebrafish genome database we have identified a multi-gene family of Group II immune-related, lectin-like receptors (illrs) whose members possess inhibiting and/or activating signaling motifs typical of Group V NK receptors. Illr genes are differentially expressed in the myeloid and lymphoid lineages, suggesting that they may play important roles in the immune functions of multiple hematopoietic cell lineages.
Bibliography:	http://dx.doi.org/10.1007/s00251-005-0064-3 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0093-7711 1432-1211
DOI:	10.1007/s00251-005-0064-3