Search Results - "Granoff, Dan"

Eculizumab treatment and impaired opsonophagocytic killing of meningococci by whole blood from immunized adults by Konar, Monica, Granoff, Dan M.

“…Eculizumab, a humanized anti–complement C5 monoclonal antibody (mAb) for treatment of paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic…”
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Review of Meningococcal Group B Vaccines by Granoff, Dan M.

“…No broadly effective vaccines are available for prevention of group B meningococcal disease, which accounts for>50% of all cases. The group B capsule is an…”
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Binding of Complement Factor H (fH) to Neisseria meningitidis Is Specific for Human fH and Inhibits Complement Activation by Rat and Rabbit Sera by Granoff, Dan M, Welsch, Jo Anne, Ram, Sanjay

“…Complement factor H (fH), a molecule that downregulates complement activation, binds to Neisseria meningitidis and increases resistance to serum bactericidal…”
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Meningococcal B Vaccine during a University Outbreak by Granoff, Dan M

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Relative importance of complement-mediated bactericidal and opsonic activity for protection against meningococcal disease by Granoff, Dan M

“…Abstract Killing of Neisseria meningitidis can result from complement-mediated serum bactericidal activity (SBA) or opsonophagocytosis (OPA), or a combination…”
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A Meningococcal Native Outer Membrane Vesicle Vaccine With Attenuated Endotoxin and Overexpressed Factor H Binding Protein Elicits Gonococcal Bactericidal Antibodies by Beernink, Peter T, Ispasanie, Emma, Lewis, Lisa A, Ram, Sanjay, Moe, Gregory R, Granoff, Dan M

“…Meningococcal outer membrane vesicle (OMV) vaccines are prepared with detergents to remove endotoxin, which also remove desirable antigens such as factor H…”
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Serum Bactericidal Antibody Responses of Students Immunized With a Meningococcal Serogroup B Vaccine in Response to an Outbreak on a University Campus by Lujan, Eduardo, Winter, Kathleen, Rovaris, Jillandra, Liu, Qin, Granoff, Dan M.

“…Background. MenB-4C is a recently licensed meningococcal serogroup B vaccine. For vaccine licensure, short-term efficacy was inferred from serum bactericidal…”
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A meningococcal NOMV-FHbp vaccine for Africa elicits broader serum bactericidal antibody responses against serogroup B and non-B strains than a licensed serogroup B vaccine by Pajon, Rolando, Lujan, Eduardo, Granoff, Dan M

“…Highlights • Epidemic serogroup A meningococcal disease in Sub-Sahara Africa is currently controlled by a monovalent serogroup A conjugate vaccine. • Epidemics…”
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Impaired Immunogenicity of Meningococcal Neisserial Surface Protein A in Human Complement Factor H Transgenic Mice by Lujan, Eduardo, Pajon, Rolando, Granoff, Dan M

“…Neisserial surface protein A (NspA) is a highly conserved outer membrane protein previously investigated as a meningococcal vaccine candidate. Despite…”
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Binding of complement factor H to PorB3 and NspA enhances resistance of Neisseria meningitidis to anti-factor H binding protein bactericidal activity by Giuntini, Serena, Pajon, Rolando, Ram, Sanjay, Granoff, Dan M

“…Among 25 serogroup B Neisseria meningitidis clinical isolates, we identified four (16%) with high factor H binding protein (FHbp) expression that were…”
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Human factor H (FH) impairs protective meningococcal anti-FHbp antibody responses and the antibodies enhance FH binding by Costa, Isabella, Pajon, Rolando, Granoff, Dan M

“…The meningococcal 4CMenB vaccine (Bexsero; Novartis) contains four antigens that can elicit serum bactericidal activity, one of which is factor H (FH)-binding…”
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Commentary: European Medicines Agency recommends approval of a broadly protective vaccine against serogroup B meningococcal disease by Granoff, Dan M

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Fatal Nongroupable Neisseria meningitidis Disease in Vaccinated Patient Receiving Eculizumab by Nolfi-Donegan, Deirdre, Konar, Monica, Vianzon, Vianca, MacNeil, Jessica, Cooper, James, Lurie, Perrianne, Sedivy, Judi, Wang, Xin, Granoff, Dan M, McNamara, Lucy

“…Patients receiving eculizumab have an increased risk for meningococcal disease, but most reported cases are attributable to encapsulated meningococcal strains…”
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Breadth and Duration of Meningococcal Serum Bactericidal Activity in Health Care Workers and Microbiologists Immunized with the MenB-FHbp Vaccine by Lujan, Eduardo, Partridge, Elizabeth, Giuntini, Serena, Ram, Sanjay, Granoff, Dan M

“…MenB-FHbp is a meningococcal serogroup B vaccine with two factor H binding protein (FHbp) antigens from subfamilies A and B. For licensure, efficacy was…”
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Neisseria meningitidis Urethritis Outbreak Isolates Express a Novel Factor H Binding Protein Variant That Is a Potential Target of Group B-Directed Meningococcal (MenB) Vaccines by Tzeng, Yih-Ling, Giuntini, Serena, Berman, Zachary, Sannigrahi, Soma, Granoff, Dan M, Stephens, David S

“…Factor H binding protein (FHbp) is an important virulence factor that binds a negative regulator of the alternative complement pathway, human factor H (FH)…”
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A Newly-Identified Polymorphism in Rhesus Macaque Complement Factor H Modulates Binding Affinity for Meningococcal FHbp by Konar, Monica, Beernink, Peter T, Granoff, Dan M

“…Two meningococcal serogroup B vaccines contain Factor H binding protein (FHbp). Binding of Factor H (FH) to FHbp was thought to be specific for human or…”
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A Meningococcal Outer Membrane Vesicle Vaccine with Overexpressed Mutant FHbp Elicits Higher Protective Antibody Responses in Infant Rhesus Macaques than a Licensed Serogroup B Vaccine by Beernink, Peter T, Vianzon, Vianca, Lewis, Lisa A, Moe, Gregory R, Granoff, Dan M

“…MenB-4C (Bexsero; GlaxoSmithKline Biologicals) is a licensed meningococcal vaccine for capsular B strains. The vaccine contains detergent-extracted outer…”
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Differential effects of therapeutic complement inhibitors on serum bactericidal activity against non-groupable meningococcal isolates recovered from patients treated with eculizumab by Granoff, Dan M, Kim, Howard, Topaz, Nadav, MacNeil, Jessica, Wang, Xin, McNamara, Lucy A

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Meningococcal factor H-binding protein vaccines with decreased binding to human complement factor H have enhanced immunogenicity in human factor H transgenic mice by Rossi, Raffaella, Granoff, Dan M, Beernink, Peter T

“…Highlights • We constructed two meningococcal factor H binding protein (fHbp) sub-family B mutants. • Both mutants had decreased binding of human factor H. •…”
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The role of anti-NHba antibody in bactericidal activity elicited by the meningococcal serogroup B vaccine, MenB-4C by Partridge, Elizabeth, Lujan, Eduardo, Giuntini, Serena, Vu, David M., Granoff, Dan M.

“…•MenB-4C (Bexsero®) is a multicomponent serogroup B meningococcal vaccine.•The bactericidal role of antibody to one of the four antigens, Neisserial Heparin…”
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