Search Results - "Granier, Sébastien"

A new era of GPCR structural and chemical biology by Granier, Sébastien, Kobilka, Brian

“…G protein–coupled receptors (GPCRs) are versatile molecular machines that regulate the majority of physiological responses to chemically diverse hormones and…”
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Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling by El Moustaine, Driss, Granier, Sébastien, Doumazane, Etienne, Scholler, Pauline, Rahmeh, Rita, Bron, Patrick, Mouillac, Bernard, Banères, Jean-Louis, Rondard, Philippe, Pin, Jean-Philippe

“…The eight metabotropic glutamate receptors (mGluRs) are key modulators of synaptic transmission and are considered promising targets for the treatment of…”
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Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy by Rahmeh, Rita, Damian, Marjorie, Cottet, Martin, Orcel, Hélène, Mendre, Christiane, Durroux, Thierry, Sharma, K. Shivaji, Durand, Grégory, Pucci, Bernard, Trinquet, Eric, Zwier, Jurriaan M, Deupi, Xavier, Bron, Patrick, Banères, Jean-Louis, Mouillac, Bernard, Granier, Sébastien

“…G protein-coupled receptors (GPCRs) are seven-transmembrane proteins that mediate most cellular responses to hormones and neurotransmitters, representing the…”
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Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy by Vasiliauskaité-Brooks, Ieva, Healey, Robert D., Rochaix, Pascal, Saint-Paul, Julie, Sounier, Rémy, Grison, Claire, Waltrich-Augusto, Thierry, Fortier, Mathieu, Hoh, François, Saied, Essa M., Arenz, Christoph, Basu, Shibom, Leyrat, Cédric, Granier, Sébastien

“…Alkaline ceramidases (ACERs) are a class of poorly understood transmembrane enzymes controlling the homeostasis of ceramides. They are implicated in human…”
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GNAS: A New Nephrogenic Cause of Inappropriate Antidiuresis by Bichet, Daniel G, Granier, Sébastien, Bockenhauer, Detlef

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7TM proteins are not necessarily GPCRs by Vasiliauskaité-Brooks, Ieva, Healey, Robert D., Granier, Sébastien

“…In this review article, we summarize the current knowledge on a large and diverse superfamily of seven-pass transmembrane proteins functionally independent…”
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Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins by Lambey, Paul, Otun, Omolade, Cong, Xiaojing, Hoh, François, Brunel, Luc, Verdié, Pascal, Grison, Claire M, Peysson, Fanny, Jeannot, Sylvain, Durroux, Thierry, Bechara, Cherine, Granier, Sébastien, Leyrat, Cédric

“…(SA) leukocidin ED (LukED) belongs to a family of bicomponent pore forming toxins that play important roles in SA immune evasion and nutrient acquisition…”
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Bringing GPCR Structural Biology to Medical Applications: Insights from Both V2 Vasopressin and Mu-Opioid Receptors by Fouillen, Aurélien, Bous, Julien, Granier, Sébastien, Mouillac, Bernard, Sounier, Remy

“…G-protein coupled receptors (GPCRs) are versatile signaling proteins that regulate key physiological processes in response to a wide variety of extracellular…”
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Structure, dynamics and transferability of the metal-dependent polyhistidine tetramerization motif TetrHis for single-chain Fv antibodies by Healey, Robert D., Couillaud, Louise, Hoh, François, Mouhand, Assia, Fouillen, Aurelien, Couvineau, Pierre, Granier, Sébastien, Leyrat, Cédric

“…The polyhistidine (6XHis) motif is one of the most ubiquitous protein purification tags. The 6XHis motif enables the binding of tagged proteins to various…”
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Cryo-electron microscopy structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex by Bous, Julien, Orcel, Hélène, Floquet, Nicolas, Leyrat, Cédric, Lai-Kee-Him, Joséphine, Gaibelet, Gérald, Ancelin, Aurélie, Saint-Paul, Julie, Trapani, Stefano, Louet, Maxime, Sounier, Rémy, Déméné, Hélène, Granier, Sébastien, Bron, Patrick, Mouillac, Bernard

“…The antidiuretic hormone arginine-vasopressin (AVP) forms a signaling complex with the V2 receptor (V2R) and the G protein, promoting kidney water…”
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An automated platform for structural analysis of membrane proteins through serial crystallography by Healey, Robert D., Basu, Shibom, Humm, Anne-Sophie, Leyrat, Cedric, Cong, Xiaojing, Golebiowski, Jérôme, Dupeux, Florine, Pica, Andrea, Granier, Sébastien, Márquez, José Antonio

“…Membrane proteins are central to many pathophysiological processes, yet remain very difficult to analyze structurally. Moreover, high-throughput…”
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Amphipols in G Protein-Coupled Receptor Pharmacology: What Are They Good For? by Mary, Sophie, Damian, Marjorie, Rahmeh, Rita, Mouillac, Bernard, Marie, Jacky, Granier, Sébastien, Banères, Jean-Louis

“…G protein-coupled receptors are at a central node of all cell communications. Investigating their molecular functioning is therefore crucial for both academic…”
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Structure of the δ-opioid receptor bound to naltrindole by Granier, Sébastien, Manglik, Aashish, Kruse, Andrew C., Kobilka, Tong Sun, Thian, Foon Sun, Weis, William I., Kobilka, Brian K.

“…The X-ray crystal structure of the mouse δ-opioid receptor in complex with the subtype-selective antagonist naltrindole is reported. Where opiates hit home…”
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FRET-based measurement of GPCR conformational changes by Granier, Sébastien, Kim, Samuel, Fung, Juan José, Bokoch, Michael P, Parnot, Charles

“…The C-termini of G protein-coupled receptors (GPCRs) interact with specific kinases and arrestins in an agonist-dependent manner suggesting that conformational…”
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Propagation of conformational changes during μ-opioid receptor activation by Sounier, Rémy, Mas, Camille, Steyaert, Jan, Laeremans, Toon, Manglik, Aashish, Huang, Weijiao, Kobilka, Brian K., Déméné, Héléne, Granier, Sébastien

“…NMR spectroscopy reveals the conformational changes of the μ-opioid receptor that are associated with receptor activation, helping to explain why the…”
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Design, Synthesis, and Characterization of New δ Opioid Receptor-Selective Fluorescent Probes and Applications in Single-Molecule Microscopy of Wild-Type Receptors by Drakopoulos, Antonios, Koszegi, Zsombor, Seier, Kerstin, Hübner, Harald, Maurel, Damien, Sounier, Rémy, Granier, Sébastien, Gmeiner, Peter, Calebiro, Davide, Decker, Michael

“…The delta opioid receptor (δOR or DOR) is a G protein-coupled receptor (GPCR) showing a promising profile as a drug target for nociception and analgesia…”
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Crystal structure of the µ-opioid receptor bound to a morphinan antagonist by Manglik, Aashish, Kruse, Andrew C., Kobilka, Tong Sun, Thian, Foon Sun, Mathiesen, Jesper M., Sunahara, Roger K., Pardo, Leonardo, Weis, William I., Kobilka, Brian K., Granier, Sébastien

“…Opium is one of the world’s oldest drugs, and its derivatives morphine and codeine are among the most used clinical drugs to relieve severe pain. These…”
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Structural insights into µ-opioid receptor activation by Huang, Weijiao, Manglik, Aashish, Venkatakrishnan, A. J., Laeremans, Toon, Feinberg, Evan N., Sanborn, Adrian L., Kato, Hideaki E., Livingston, Kathryn E., Thorsen, Thor S., Kling, Ralf C., Granier, Sébastien, Gmeiner, Peter, Husbands, Stephen M., Traynor, John R., Weis, William I., Steyaert, Jan, Dror, Ron O., Kobilka, Brian K.

“…Activation of the μ-opioid receptor (μOR) is responsible for the efficacy of the most effective analgesics. To shed light on the structural basis for μOR…”
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Molecular insights into the biased signaling mechanism of the μ-opioid receptor by Cong, Xiaojing, Maurel, Damien, Déméné, Hélène, Vasiliauskaité-Brooks, Ieva, Hagelberger, Joanna, Peysson, Fanny, Saint-Paul, Julie, Golebiowski, Jérôme, Granier, Sébastien, Sounier, Rémy

“…GPCR functional selectivity opens new opportunities for the design of safer drugs. Ligands orchestrate GPCR signaling cascades by modulating the receptor…”
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Structural insights into adiponectin receptors suggest ceramidase activity by Vasiliauskaité-Brooks, Ieva, Sounier, Remy, Rochaix, Pascal, Bellot, Gaëtan, Fortier, Mathieu, Hoh, François, De Colibus, Luigi, Bechara, Chérine, Saied, Essa M., Arenz, Christoph, Leyrat, Cédric, Granier, Sébastien

“…Structures of the adiponectin receptors ADIPOR1 and ADIPOR2 combined with molecular dynamics simulations and enzymatic assays suggest that both receptors have…”
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